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Oas1b
Gene Detail
 Symbol
Name
ID
Oas1b
2'-5' oligoadenylate synthetase 1B
MGI:97430
BioType Conflict
Synonyms Flavivirus resistance, Flv, L1, Mmu-L1, Oias2, Oias-2, Wnv
Feature Type protein coding gene
Genetic Map
Chromosome 5
60.64 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:120812635-120824163 bp, + strand
From VEGA annotation of GRCm38

  11529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: oligo(A) synthetase
Gene Tree: Oas1b
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(3) Targeted(1)
 
Spontaneous mutations of this gene result in altered susceptibility to viral infection.
 
Interactions
Oas1b interacts with 130 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process defense response to virus, immune response, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function ATP binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(5) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043313 (Evidence)
Ensembl Gene ModelENSMUSG00000029605 (Evidence)
Entrez Gene23961 (Evidence)
UniGene233471
DFCITC1584848
DoTSDT.40175058, DT.99856678
NIA Mouse Gene IndexU006112
International Mouse Knockout Project StatusOas1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043313 VEGA Gene Model | MGI Sequence Detail 11529 C57BL/6J ±  kb
transcript OTTMUST00000113648 VEGA | MGI Sequence Detail 1837 Not Applicable 
polypeptide OTTMUSP00000063513 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(3) UniProt(7)
Polymorphisms SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026774 2'-5'-oligoadenylate synthase
InterPro IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
InterPro IPR006117 2-5-oligoadenylate synthetase, conserved site
InterPro IPR006116 2-5-oligoadenylate synthetase, N-terminal
Protein Ontology PR:000012102 2'-5'-oligoadenylate synthetase 1B
References (Earliest) J:13005 Webster LT, Inheritance of resistance of mice to enteric bacterial and neurotropic virus infection. J Exp Med. 1937;65:261-286
(Latest) J:186172 Courtney SC, et al., Identification of novel host cell binding partners of oas1b, the protein conferring resistance to flavivirus-induced disease in mice. J Virol. 2012 Aug;86(15):7953-63
All references(53)
Other
accession IDs
MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory