Oas1b
Gene Detail

Symbol Name ID

Oas1b 2'-5' oligoadenylate synthetase 1B MGI:97430

Synonyms

Flavivirus resistance, Flv, L1, Mmu-L1, Oias2, Oias-2, Wnv

Feature Type

protein coding gene

Genetic Map

Chromosome 5

60.64 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:120812635-120824158 bp, + strand From Ensembl annotation of GRCm38   11524 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: oligo(A) synthetase
Gene Tree: Oas1b

Alleles and phenotypes

All alleles(4) : Targeted(1) Spontaneous(3)
 

Spontaneous mutations of this gene result in altered susceptibility to viral infection.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	defense response to virus, immune response, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	ATP binding, double-stranded RNA binding, ...

External Resources: FuncBase

Expression

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(5) cDNA(20)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000029605 (Evidence)
Entrez Gene	23961 (Evidence)
UniGene	233471
DFCI	TC1584848
DoTS	DT.40175058, DT.99856678
NIA Mouse Gene Index	U006112
International Mouse Knockout Project Status	Oas1b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000029605	Ensembl Gene Model | MGI Sequence Detail	11524	C57BL/6J
transcript	ENSMUST00000086377	Ensembl | MGI Sequence Detail	1832	Not Applicable
polypeptide	ENSMUSP00000083564	Ensembl | MGI Sequence Detail	251	Not Applicable

All sequences(33) RefSeq(3) UniProt(6)

Protein-related information

Resource	ID	Description
InterPro	IPR026774	2'-5'-oligoadenylate synthase
InterPro	IPR018952	2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
InterPro	IPR006117	2-5-oligoadenylate synthetase, conserved site
InterPro	IPR006116	2-5-oligoadenylate synthetase, N-terminal
Protein Ontology	PR:000012102	2'-5'-oligoadenylate synthetase 1B

References

(Earliest) J:13005 Webster LT, Inheritance of resistance of mice to enteric bacterial and neurotropic virus infection. J Exp Med. 1937;65:261-286
(Latest) J:186172 Courtney SC, et al., Identification of novel host cell binding partners of oas1b, the protein conferring resistance to flavivirus-induced disease in mice. J Virol. 2012 Aug;86(15):7953-63
All references(52)

Other accession IDs

MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562