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Oas1b Gene Detail
Summary
  • Symbol
    Oas1b
  • Name
    2'-5' oligoadenylate synthetase 1B
  • Synonyms
    Flavivirus resistance, Flv, L1, Mmu-L1, Oias2, Oias-2, Wnv
Location & Maps
more
  • Sequence Map
    Chr5:120812635-120824163 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11529 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
    Orthology source: HGNC
  • Synonyms
    IFI-4, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973

  • Chr Location
    12q24.2; chr12:112906934-112932049 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    2 involving Oas1b
Spontaneous mutations of this gene result in altered susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043313 VEGA Gene Model | MGI Sequence Detail 11529 C57BL/6J ±  kb
transcript OTTMUST00000113648 VEGA | MGI Sequence Detail 1837 Not Applicable  
polypeptide OTTMUSP00000063513 VEGA | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012102 2'-5'-oligoadenylate synthetase 1B
  • InterPro Domains
    IPR026774 2'-5'-oligoadenylate synthase
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, conserved site
    IPR006116 2-5-oligoadenylate synthetase, N-terminal
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
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  • All nucleic 25
    Genomic 5
    cDNA 20

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562
References
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  • Summaries
    All 50
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:13005 Webster LT, Inheritance of resistance of mice to enteric bacterial and neurotropic virus infection. J Exp Med. 1937;65:261-286
  • Latest
    J:186172 Courtney SC, et al., Identification of novel host cell binding partners of oas1b, the protein conferring resistance to flavivirus-induced disease in mice. J Virol. 2012 Aug;86(15):7953-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory