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Ntrk3
Gene Detail
Symbol

Name
ID
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
MGI:97385
Synonyms
TrkC
Feature Type
protein coding gene
Genetic Map
Chromosome 7
44.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:78192362-78578408 bp, - strand
From VEGA annotation of GRCm38

  386047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk3

Human
homologs
Human Homolog NTRK3, neurotrophic tyrosine kinase, receptor, type 3
NCBI Gene ID 4916
neXtProt AC  NX_Q16288
Human Synonyms  gp145(trkC), TRKC
Human Chr (Location)  15q25; chr15:87876717-88256731 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.
 
Phenotype Images(1)
Interactions
Ntrk3 interacts with 116 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process activation of MAPK activity, activation of protein kinase B activity, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, ephrin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (129 records)
Data Summary: Results (682)    Tissues (342)    Images (131)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 61
RNA in situ 462
Western blot 12
RT-PCR 134
RNase protection 13
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(17) Primer pair(6) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021139 (Evidence)
Ensembl Gene ModelENSMUSG00000059146 (Evidence)
Entrez Gene18213 (Evidence)
DFCITC1584364, TC1648787, TC1655572
NIA Mouse Gene IndexU028730, U355247
EC2.7.10.1
Consensus CDS ProjectCCDS21371.1, CCDS21372.1
International Mouse Knockout Project StatusNtrk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021139 VEGA Gene Model | MGI Sequence Detail 386047 C57BL/6J ±  kb
transcript OTTMUST00000050042 VEGA | MGI Sequence Detail 3300 Not Applicable 
polypeptide OTTMUSP00000023300 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(2784 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011471 NT-3 growth factor receptor
References
(Earliest) J:2280 Barbacid M, et al., The trk family of tyrosine protein kinase receptors. Biochim Biophys Acta. 1991 Dec 10;1072(2-3):115-27
(Latest) J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
All references(214)
Other
accession IDs
MGD-MRK-12944, MGI:2142211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory