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Ntrk3
Gene Detail
Symbol

Name
ID
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
MGI:97385
Synonyms
TrkC
Feature Type
protein coding gene
Genetic Map
Chromosome 7
44.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:78192362-78578408 bp, - strand
From VEGA annotation of GRCm38

  386047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NTRK3
Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk3

Human
homologs
NTRK3, neurotrophic tyrosine kinase, receptor, type 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4916
neXtProt AC: NX_Q16288

Human Synonyms: gp145(trkC), GP145-TrkC, TRKC

Human Chr (Location): 15q25; chr15:87874999-88256796 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.
 
Phenotype Images(1)
Interactions
Ntrk3 interacts with 116 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process activation of GTPase activity, activation of MAPK activity, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, ephrin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (132 records)
Data Summary: Results (682)    Tissues (342)    Images (131)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 61
RNA in situ 462
Western blot 12
RT-PCR 134
RNase protection 13
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NTRK3 ; Xenbase ntrk3    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(19) Primer pair(6) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021139 (Evidence)
Ensembl Gene Model ENSMUSG00000059146 (Evidence)
Entrez Gene 18213 (Evidence)
DFCI TC1584364, TC1615566, TC1648787, TC1655572
NIA Mouse Gene Index U028729, U028730, U355247
EC 2.7.10.1
Consensus CDS Project CCDS21371.1, CCDS21372.1
International Mouse Phenotyping Consortium Status Ntrk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021139 VEGA Gene Model | MGI Sequence Detail 386047 C57BL/6J ±  kb
transcript OTTMUST00000131058 VEGA | MGI Sequence Detail 2774 Not Applicable 
polypeptide OTTMUSP00000070141 VEGA | MGI Sequence Detail 864 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(18) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(2784 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011471 NT-3 growth factor receptor
References
(Earliest) J:2280 Barbacid M, et al., The trk family of tyrosine protein kinase receptors. Biochim Biophys Acta. 1991 Dec 10;1072(2-3):115-27
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(217)
Other
accession IDs
MGD-MRK-12944, MGI:2142211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory