About   Help   FAQ
Ntrk3 Gene Detail
Summary
  • Symbol
    Ntrk3
  • Name
    neurotrophic tyrosine kinase, receptor, type 3
  • Synonyms
    TrkC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97385
    NCBI Gene: 18213
  • Gene Overview
    MyGene.info: NTRK3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:78175959-78738012 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      562054 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 44.01 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    gp145(trkC), GP145-TrkC, TRKC
  • Links
    NCBI Gene ID: 4916
    neXtProt AC: NX_Q16288
    UniProt: Q16288

  • Chr Location
    15q25.3; chr15:87859749-88256796 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 7 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021139 VEGA Gene Model | MGI Sequence Detail 562054 C57BL/6J ±  kb
    transcript OTTMUST00000131058 VEGA | MGI Sequence Detail 2774 Not Applicable  
    polypeptide OTTMUSP00000070141 VEGA | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3905 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • EC
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR013151 Immunoglobulin
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR020777 Tyrosine-protein kinase, neurotrophic receptor
      IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
      IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 20
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12944, MGI:2142211
    References
    more
    • Summaries
      All 255
      Developmental Gene Expression 146
      Diseases 1
      Gene Ontology 15
      Phenotypes 76
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory