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Ntrk3 Gene Detail
Summary
  • Symbol
    Ntrk3
  • Name
    neurotrophic tyrosine kinase, receptor, type 3
  • Synonyms
    TrkC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97385
    NCBI Gene: 18213
  • Gene Overview
    MyGene.info: NTRK3
Location & Maps
more
  • Sequence Map
    Chr7:78175959-78738012 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      562054 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
    Orthology source: HomoloGene
  • Synonyms
    gp145(trkC), GP145-TrkC, TRKC
  • Links
    NCBI Gene ID: 4916
    neXtProt AC: NX_Q16288

  • Chr Location
    15q25; chr15:87874999-88256796 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 7 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    9
  • Transgenic
    1
  • Genomic Mutations
    3 involving Ntrk3
  • Incidental Mutations
    APF , CvDC
Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021139 VEGA Gene Model | MGI Sequence Detail 562054 C57BL/6J ±  kb
transcript OTTMUST00000131058 VEGA | MGI Sequence Detail 2774 Not Applicable  
polypeptide OTTMUSP00000070141 VEGA | MGI Sequence Detail 864 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3905 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000011471 NT-3 growth factor receptor
  • EC
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR013151 Immunoglobulin
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR020777 Tyrosine-protein kinase, neurotrophic receptor
    IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3
    IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 19
    Primer pair 6
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12944, MGI:2142211
References
more
  • Summaries
    All 218
    Developmental Gene Expression 134
    Gene Ontology 13
    Phenotypes 73
  • Earliest
    J:2280 Barbacid M, et al., The trk family of tyrosine protein kinase receptors. Biochim Biophys Acta. 1991 Dec 10;1072(2-3):115-27
  • Latest
    J:228865 Law C, et al., Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory