Ntrk1
Gene Detail

Symbol Name ID

Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 MGI:97383

Synonyms

Tkr, TrkA

Feature Type

protein coding gene

Genetic Map

Chromosome 3

38.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr3:87778244-87795162 bp, - strand From NCBI annotation of GRCm38   16919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk1

Human homologs

Human Homolog		NTRK1, neurotrophic tyrosine kinase, receptor, type 1
NCBI Gene ID		4914
neXtProt AC		NX_P04629
Human Synonyms		MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
Human Chr (Location)		1q21-q22; chr1:156785542-156851642 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NTRK1

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.

 
Human Diseases Modeled Using Mouse Ntrk1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (69 annotations)

Process	axon guidance, axonogenesis involved in innervation, ...
Component	axon, cell surface, ...
Function	ATP binding, ephrin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (142 records)
Data Summary: Results (352)    Tissues (172)    Images (77)
Theiler Stages: 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	53
RNA in situ	245
Northern blot	15
RT-PCR	39

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(24) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000028072 (Evidence)
Entrez Gene	18211 (Evidence)
UniGene	80682
DFCI	TC1600675, TC1615338, TC1704007
DoTS	DT.91306924, DT.97357648
NIA Mouse Gene Index	U024235
EC	2.7.10.1
Consensus CDS Project	CCDS50947.1
International Mouse Knockout Project Status	Ntrk1

Sequences

Length	Strain/Species
genomic	18211	NCBI Gene Model | MGI Sequence Detail	16919	C57BL/6J
transcript	NM_001033124	RefSeq | MGI Sequence Detail	2606	C57BL/6
polypeptide	Q3UFB7	UniProt | EBI | MGI Sequence Detail	799	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR020777	Tyrosine-protein kinase, neurotrophic receptor
InterPro	IPR020461	Tyrosine-protein kinase, neurotrophic receptor, type 1
InterPro	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology	PR:000011469	high affinity nerve growth factor receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:192475 Asahina H, et al., Distribution of protocadherin 9 protein in the developing mouse nervous system. Neuroscience. 2012 Dec 6;225:88-104
All references(245)

Other accession IDs

MGD-MRK-12942, MGD-MRK-15125, MGI:2140079