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Ntrk1
Gene Detail
Symbol

Name
ID
Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
MGI:97383
Synonyms
Tkr, TrkA
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr3:87778244-87795162 bp, - strand
From VEGA annotation of GRCm38

  16919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NTRK1
Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk1

Human
homologs
NTRK1, neurotrophic tyrosine kinase, receptor, type 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4914
neXtProt AC: NX_P04629

Human Synonyms: MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA

Human Chr (Location): 1q21-q22; chr1:156815750-156881850 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NTRK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
 
Human Diseases Modeled in Mice Using Ntrk1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Ntrk1 interacts with 21 markers (Mir206, Mir344d-1, Mir344d-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process axon guidance, axonogenesis involved in innervation, ...
Component axon, cell surface, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (171 records)
Data Summary: Results (363)    Tissues (174)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 56
RNA in situ 245
Northern blot 17
Western blot 3
RT-PCR 42
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NTRK1 ZFIN ntrk1    NEW 
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(24) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051890 (Evidence)
Ensembl Gene Model ENSMUSG00000028072 (Evidence)
Entrez Gene 18211 (Evidence)
UniGene 80682
DFCI TC1600675, TC1615338, TC1704007
DoTS DT.91306924, DT.97357648
NIA Mouse Gene Index U024235
EC 2.7.10.1
Consensus CDS Project CCDS50947.1
International Mouse Phenotyping Consortium Status Ntrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051890 VEGA Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
transcript OTTMUST00000130657 VEGA | MGI Sequence Detail 2588 Not Applicable 
polypeptide OTTMUSP00000069994 VEGA | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011469 high affinity nerve growth factor receptor
References
(Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:221644 Calvo L, et al., Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015 May 6;35(18):7190-202
All references(286)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12942, MGD-MRK-15125, MGI:2140079

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory