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Gene Detail
neurotrophic tyrosine kinase, receptor, type 1
Synonyms Tkr, TrkA
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.62 cM
Detailed Genetic Map ± 1 cM

Mapping data(11)
Sequence Map
Chr3:87778244-87795162 bp, - strand
From NCBI annotation of GRCm38

  16919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk1

Human Homolog NTRK1, neurotrophic tyrosine kinase, receptor, type 1
NCBI Gene ID 4914
neXtProt AC  NX_P04629
Human Synonyms  MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
Human Chr (Location)  1q21-q22; chr1:156815750-156881850 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NTRK1
alleles, and
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Human Diseases Modeled Using Mouse Ntrk1 (1)    Alleles Annotated to Human Diseases(2)   
Ntrk1 interacts with 21 markers (Mir206, Mir344d-1, Mir344d-2, ...)
Gene Ontology
All GO classifications: (81 annotations)
Process axon guidance, axonogenesis involved in innervation, ...
Component axon, cell surface, ...
Function ATP binding, ephrin receptor binding, ...
External Resources: FuncBase
Literature Summary: (157 records)
Data Summary: Results (354)    Tissues (174)    Images (79)
Theiler Stages: 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 55
RNA in situ 245
Northern blot 15
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(29) Genomic(1) cDNA(24) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
Ensembl Gene ModelENSMUSG00000028072 (Evidence)
Entrez Gene18211 (Evidence)
DFCITC1600675, TC1615338, TC1704007
DoTSDT.91306924, DT.97357648
NIA Mouse Gene IndexU024235
Consensus CDS ProjectCCDS50947.1
International Mouse Knockout Project StatusNtrk1
Representative SequencesLengthStrain/SpeciesFlank
genomic 18211 NCBI Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
transcript NM_001033124 RefSeq | MGI Sequence Detail 2606 C57BL/6 
polypeptide Q3UFB7 UniProt | EBI | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(44 from dbSNP Build 137)
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011469 high affinity nerve growth factor receptor
Graphical View of Protein Domain Structure
References (Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:210609 Yu T, et al., In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci. 2014 Apr 23;34(17):6098-106
All references(268)
Disease annotation references (2)
accession IDs
MGD-MRK-12942, MGD-MRK-15125, MGI:2140079

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory