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Ntrk1 Gene Detail
Summary
  • Symbol
    Ntrk1
  • Name
    neurotrophic tyrosine kinase, receptor, type 1
  • Synonyms
    Tkr, TrkA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97383
    NCBI Gene: 18211
  • Gene Overview
    MyGene.info: NTRK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:87778244-87795162 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.62 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
  • Links
    NCBI Gene ID: 4914
    neXtProt AC: NX_P04629
    UniProt: P04629

  • Chr Location
    1q23.1; chr1:156815750-156881850 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ntrk1 mouse models; 2 with human NTRK1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 11 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051890 VEGA Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
    transcript OTTMUST00000130657 VEGA | MGI Sequence Detail 2588 Not Applicable  
    polypeptide OTTMUSP00000069994 VEGA | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011469 high affinity nerve growth factor receptor
    • EC
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR020777 Tyrosine-protein kinase, neurotrophic receptor
      IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
      IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
    Molecular
    Reagents
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    • All nucleic 34
      Genomic 1
      cDNA 25
      Primer pair 3
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12942, MGD-MRK-15125, MGI:2140079
    References
    more
    • Summaries
      All 346
      Developmental Gene Expression 195
      Diseases 3
      Gene Ontology 23
      Phenotypes 77
    • Earliest
      J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
    • Latest
      J:264123 Tanimizu N, et al., Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver. Development. 2018 Apr 25;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory