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Ntrk1 Gene Detail
Summary
  • Symbol
    Ntrk1
  • Name
    neurotrophic tyrosine kinase, receptor, type 1
  • Synonyms
    Tkr, TrkA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97383
    NCBI Gene: 18211
  • Gene Overview
    MyGene.info: NTRK1
Location & Maps
more
  • Sequence Map
    Chr3:87778244-87795162 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.62 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NTRK1, neurotrophic receptor tyrosine kinase 1
    Orthology source: HomoloGene
  • Synonyms
    MTC, p140-TrkA, TRK, TRK1, Trk-A, TRKA
  • Links
    NCBI Gene ID: 4914
    neXtProt AC: NX_P04629

  • Chr Location
    1q21-q22; chr1:156815750-156881850 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ntrk1 mouse models; 2 with human NTRK1 associations

Human Disease Mouse Models
       Insensitivity to Pain, Congenital, with Anhidrosis; CIPA   OMIM: 256800 View 2 models
       Thyroid Carcinoma, Familial Medullary; MTC   OMIM: 155240
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 11 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    19
  • Genomic Mutations
    2 involving Ntrk1
  • Incidental Mutations
Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051890 VEGA Gene Model | MGI Sequence Detail 16919 C57BL/6J ±  kb
transcript OTTMUST00000130657 VEGA | MGI Sequence Detail 2588 Not Applicable  
polypeptide OTTMUSP00000069994 VEGA | MGI Sequence Detail 799 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011469 high affinity nerve growth factor receptor
  • EC
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR020777 Tyrosine-protein kinase, neurotrophic receptor
    IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
    IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
Molecular
Reagents
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  • All nucleic 31
    Genomic 1
    cDNA 24
    Primer pair 3
    Other 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12942, MGD-MRK-15125, MGI:2140079
References
more
  • Summaries
    All 294
    Developmental Gene Expression 178
    Diseases 2
    Gene Ontology 21
    Phenotypes 66
  • Earliest
    J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
  • Latest
    J:231113 Sajgo S, et al., Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol. 2016 Apr 1;524(5):1033-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory