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Mertk Gene Detail
Summary
  • Symbol
    Mertk
  • Name
    c-mer proto-oncogene tyrosine kinase
  • Synonyms
    Eyk, Mer, nmf12, Nyk, Tyro 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:96965
    NCBI Gene: 17289
  • Gene Overview
    MyGene.info: MERTK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:128698956-128802894 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103939 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-Eyk, c-mer, MER, RP38, Tyro12
  • Links
    NCBI Gene ID: 10461
    neXtProt AC: NX_Q12866
    UniProt: Q12866

  • Chr Location
    2q13; chr2:111898479-112039946 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MERTK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 8 genetic backgrounds
    48 phenotypes from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015353 VEGA Gene Model | MGI Sequence Detail 103939 C57BL/6J ±  kb
    transcript OTTMUST00000036392 VEGA | MGI Sequence Detail 4302 Not Applicable  
    polypeptide OTTMUSP00000016359 VEGA | MGI Sequence Detail 994 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1151 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 42
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12199, MGI:2651818
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 14
      Phenotypes 88
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264516 Ayata P, et al., Epigenetic regulation of brain region-specific microglia clearance activity. Nat Neurosci. 2018 Aug;21(8):1049-1060

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory