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Mertk Gene Detail
Summary
  • Symbol
    Mertk
  • Name
    MER proto-oncogene tyrosine kinase
  • Synonyms
    Eyk, Mer, nmf12, Nyk, Tyro 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:96965
    NCBI Gene: 17289
  • Gene Overview
    MyGene.info: MERTK
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:128698956-128802894 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96965
protein coding gene Chr2:128698956-128803162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026475
protein coding gene Chr2:132054389-132160505 (+)
A/J MGP_AJ_G0026439
protein coding gene Chr2:126702532-126807487 (+)
AKR/J MGP_AKRJ_G0026414
protein coding gene Chr2:130299901-130401965 (+)
BALB/cJ MGP_BALBcJ_G0026451
protein coding gene Chr2:126966120-127068129 (+)
C3H/HeJ MGP_C3HHeJ_G0026194
protein coding gene Chr2:130812956-130916717 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026896
protein coding gene Chr2:136171974-136284074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024273
protein coding gene Chr2:121529337-121634655 (+)
CAST/EiJ MGP_CASTEiJ_G0025655
protein coding gene Chr2:131051909-131159992 (+)
CBA/J MGP_CBAJ_G0026174
protein coding gene Chr2:141196890-141315814 (+)
DBA/2J MGP_DBA2J_G0026308
protein coding gene Chr2:126091699-126194410 (+)
FVB/NJ MGP_FVBNJ_G0026272
protein coding gene Chr2:124740818-124844455 (+)
LP/J MGP_LPJ_G0026413
protein coding gene Chr2:132276486-132386006 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026292
protein coding gene Chr2:145149266-145259812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026951
protein coding gene Chr2:130331696-130444309 (+)
PWK/PhJ MGP_PWKPhJ_G0025391
protein coding gene Chr2:125665642-125770089 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025193
protein coding gene Chr2:129437333-129554272 (+)
WSB/EiJ MGP_WSBEiJ_G0025729
protein coding gene Chr2:131241922-131352764 (+)



Homology
more
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-Eyk, c-mer, MER, RP38, Tyro12
  • Links
    NCBI Gene ID: 10461
    neXtProt AC: NX_Q12866
    UniProt: Q12866

  • Chr Location
    2q13; chr2:111898479-112039946 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MERTK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 8 genetic backgrounds
    48 phenotypes from multigenic genotypes
    1 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014361 Ensembl Gene Model | MGI Sequence Detail 103939 C57BL/6J ±  kb
    transcript ENSMUST00000014505 Ensembl | MGI Sequence Detail 4302 Not Applicable  
    polypeptide ENSMUSP00000014505 Ensembl | MGI Sequence Detail 994 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 42
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12199, MGI:2651818
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 14
      Phenotypes 102
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:278199 Nishi C, et al., MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation. J Biol Chem. 2019 May 3;294(18):7221-7230

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory