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Mertk Gene Detail
Summary
  • Symbol
    Mertk
  • Name
    c-mer proto-oncogene tyrosine kinase
  • Synonyms
    Eyk, Mer, nmf12, Nyk, Tyro 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:96965
    NCBI Gene: 17289
  • Gene Overview
    MyGene.info: MERTK
Location & Maps
more
  • Sequence Map
    Chr2:128698956-128802894 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103939 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.63 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MERTK, MER proto-oncogene, tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    c-Eyk, c-mer, MER, RP38, Tyro12
  • Links
    NCBI Gene ID: 10461
    neXtProt AC: NX_Q12866

  • Chr Location
    2q14.1; chr2:111898479-112039953 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MERTK associations

Human Disease Mouse Models
       Retinitis Pigmentosa 38; RP38   OMIM: 613862
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 8 genetic backgrounds
    48 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mertk
  • Incidental Mutations
Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015353 VEGA Gene Model | MGI Sequence Detail 103939 C57BL/6J ±  kb
transcript OTTMUST00000036392 VEGA | MGI Sequence Detail 4302 Not Applicable  
polypeptide OTTMUSP00000016359 VEGA | MGI Sequence Detail 994 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1151 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 41
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12199, MGI:2651818
References
more
  • Summaries
    All 105
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 13
    Phenotypes 70
  • Earliest
    J:26233 Graham DK, et al., Cloning and developmental expression analysis of the murine c-mer tyrosine kinase. Oncogene. 1995 Jun 15;10(12):2349-59
  • Latest
    J:220148 Salian-Mehta S, et al., Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):164-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory