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Mertk
Gene Detail
Symbol

Name
ID
Mertk
c-mer proto-oncogene tyrosine kinase
MGI:96965
Synonyms
Eyk, Mer, nmf12, Nyk, Tyro 12
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:128698956-128802894 bp, + strand
From VEGA annotation of GRCm38

  103939 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4626  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MERTK
Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree: Mertk

Human
homologs
MERTK, MER proto-oncogene, tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10461
neXtProt AC: NX_Q12866

Human Synonyms: c-Eyk, c-mer, MER, RP38, Tyro12

Human Chr (Location): 2q14.1; chr2:111898479-112039953 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MERTK

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Mertk interacts with 253 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process apoptotic cell clearance, natural killer cell differentiation, ...
Component cell, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (77)    Tissues (48)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
Northern blot 8
RT-PCR 14
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mertk    NEW 
Molecular
reagents
All nucleic(43) cDNA(41) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015353 (Evidence)
Ensembl Gene Model ENSMUSG00000014361 (Evidence)
Entrez Gene 17289 (Evidence)
UniGene 239655
DFCI TC1584513, TC1613280
DoTS DT.101365207, DT.530019
NIA Mouse Gene Index U002446
EC 2.7.10.1
Consensus CDS Project CCDS16716.1
International Mouse Phenotyping Consortium Status Mertk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015353 VEGA Gene Model | MGI Sequence Detail 103939 C57BL/6J ±  kb
transcript OTTMUST00000036392 VEGA | MGI Sequence Detail 4302 Not Applicable 
polypeptide OTTMUSP00000016359 VEGA | MGI Sequence Detail 994 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000010329 tyrosine-protein kinase Mer
References
(Earliest) J:26233 Graham DK, et al., Cloning and developmental expression analysis of the murine c-mer tyrosine kinase. Oncogene. 1995 Jun 15;10(12):2349-59
(Latest) J:220148 Salian-Mehta S, et al., Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):164-70
All references(108)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12199, MGI:2651818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory