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Slc3a2 Gene Detail
Summary
  • Symbol
    Slc3a2
  • Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  • Synonyms
    4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96955
    NCBI Gene: 17254
Location & Maps
more
  • Sequence Map
    Chr19:8706882-8723369 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16488 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC3A2, solute carrier family 3 (amino acid transporter heavy chain), member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC3A2, solute carrier family 3 (amino acid transporter heavy chain), member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
  • Links
    NCBI Gene ID: 6520
    neXtProt AC: NX_P08195

  • Chr Location
    11q13; chr11:62856012-62888883 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    118
  • Gene trapped
    111
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17254 NCBI Gene Model | MGI Sequence Detail 16488 C57BL/6J ±  kb
transcript NM_001161413 RefSeq | MGI Sequence Detail 2813 C57BL/6  
polypeptide P10852 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001851 4F2 cell-surface antigen heavy chain
  • InterPro Domains
    IPR013781 Glycoside hydrolase, catalytic domain
    IPR015902 Glycoside hydrolase, family 13
    IPR017853 Glycoside hydrolase superfamily
    IPR013780 Glycosyl hydrolase, family 13, all-beta
    IPR006047 Glycosyl hydrolase, family 13, catalytic domain
    IPR031984 Solute carrier family 3 member 2, N-terminal domain
Molecular
Reagents
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  • All nucleic 378
    cDNA 377
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500
References
more
  • Summaries
    All 81
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10:363-372
  • Latest
    J:219146 Bhuyan ZA, et al., CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells. Biochem Biophys Res Commun. 2014 Feb 21;444(4):628-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory