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Slc3a2 Gene Detail
Summary
  • Symbol
    Slc3a2
  • Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  • Synonyms
    4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96955
    NCBI Gene: 17254
  • Gene Overview
    MyGene.info: SLC3A2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:8706882-8723369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16488 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    38 experiments
Homology
more
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
  • Links
    NCBI Gene ID: 6520
    neXtProt AC: NX_P08195
    UniProt: P08195

  • Chr Location
    11q12.3; chr11:62856012-62888883 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    11 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057838 VEGA Gene Model | MGI Sequence Detail 16488 C57BL/6J ±  kb
    transcript OTTMUST00000142012 VEGA | MGI Sequence Detail 2813 Not Applicable  
    polypeptide OTTMUSP00000074143 VEGA | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      63 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR017853 Glycoside hydrolase superfamily
      IPR013780 Glycosyl hydrolase, all-beta
      IPR006047 Glycosyl hydrolase, family 13, catalytic domain
      IPR031984 Solute carrier family 3 member 2, N-terminal domain
    Molecular
    Reagents
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    • All nucleic 378
      cDNA 377
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
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    MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10:363-372
    • Latest
      J:243986 Ohgaki R, et al., Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol Cell Biol. 2017 Jun 01;37(11):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory