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Slc3a2
Gene Detail
 Symbol
Name
ID
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
MGI:96955
Synonyms 4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr19:8706882-8723369 bp, - strand
From NCBI annotation of GRCm38

  16488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: cell surface antigen 4F2 heavy chain
Gene Tree: Slc3a2

Human
homologs
Human Homolog SLC3A2, solute carrier family 3 (amino acid transporter heavy chain), member 2
NCBI Gene ID 6520
neXtProt AC  NX_P08195
Human Synonyms  4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Human Chr (Location)  11q13; chr11:62856012-62888883 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(117) : Gene trapped(111) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
 
Interactions
Slc3a2 interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component cell junction, cell surface, ...
Function catalytic activity, cation binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (252)    Tissues (25)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 252
cDNA source data(377)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(378) cDNA(377) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000010095 (Evidence)
Entrez Gene17254 (Evidence)
UniGene4114
DFCITC1573129, TC1626398, TC1641586, TC1653360, TC1773437
DoTSDT.495694, DT.94201184, DT.94412630, DT.94412637, DT.94412640
NIA Mouse Gene IndexU038775
Consensus CDS ProjectCCDS29540.1, CCDS50381.1
International Mouse Knockout Project StatusSlc3a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17254 NCBI Gene Model | MGI Sequence Detail 16488 C57BL/6J ±  kb
transcript NM_001161413 RefSeq | MGI Sequence Detail 2813 C57BL/6 
polypeptide P10852 UniProt | EBI | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR015902 Glycoside hydrolase, family 13
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
Protein Ontology PR:000001851 4F2 cell-surface antigen heavy chain
Graphical View of Protein Domain Structure
References (Earliest) J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10:363-372
(Latest) J:194762 Boulter E, et al., CD98hc (SLC3A2) regulation of skin homeostasis wanes with age. J Exp Med. 2013 Jan 14;210(1):173-90
All references(85)
Other
accession IDs
MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory