About   Help   FAQ
Slc3a2
Gene Detail
Symbol

Name
ID
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
MGI:96955
Synonyms
4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(38)
Sequence Map
Chr19:8706882-8723369 bp, - strand
From NCBI annotation of GRCm38

  16488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SLC3A2
Protein SuperFamily: cell surface antigen 4F2 heavy chain
Gene Tree: Slc3a2

Human
homologs
SLC3A2, solute carrier family 3 (amino acid transporter heavy chain), member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6520
neXtProt AC: NX_P08195

Human Synonyms: 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE

Human Chr (Location): 11q13; chr11:62856012-62888883 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(117) : Gene trapped(111) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
 
Interactions
Slc3a2 interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component cell surface, cytoplasm, ...
Function catalytic activity, cation binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (252)    Tissues (25)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 252
cDNA source data(377)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc3a2 ; ZFIN slc3a2a    NEW 
Molecular
reagents
All nucleic(378) cDNA(377) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000010095 (Evidence)
Entrez Gene 17254 (Evidence)
UniGene 4114
DFCI TC1573129, TC1626398, TC1641586, TC1653360, TC1773437
DoTS DT.495694, DT.94201184, DT.94412630, DT.94412637, DT.94412640
NIA Mouse Gene Index U038775
Consensus CDS Project CCDS29540.1, CCDS50381.1
International Mouse Phenotyping Consortium Status Slc3a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17254 NCBI Gene Model | MGI Sequence Detail 16488 C57BL/6J ±  kb
transcript NM_001161413 RefSeq | MGI Sequence Detail 2813 C57BL/6 
polypeptide P10852 UniProt | EBI | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR015902 Glycoside hydrolase, family 13
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
Protein Ontology PR:000001851 4F2 cell-surface antigen heavy chain
Graphical View of Protein Domain Structure
References
(Earliest) J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10:363-372
(Latest) J:219146 Bhuyan ZA, et al., CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells. Biochem Biophys Res Commun. 2014 Feb 21;444(4):628-33
All references(84)
Other
accession IDs
MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory