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Mdm1 Gene Detail
Summary
  • Symbol
    Mdm1
  • Name
    transformed mouse 3T3 cell double minute 1
  • Synonyms
    Arrd2, Mdm-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96951
    NCBI Gene: 17245
Location & Maps
more
  • Sequence Map
    Chr10:118141787-118168997 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27211 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.65 cM, cytoband C1-C3
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    MDM1, Mdm1 nuclear protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MDM1, Mdm1 nuclear protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 56890
    neXtProt AC: NX_Q8TC05

  • Chr Location
    12q15; chr12:68294566-68332381 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9692
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MDM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • QTL
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Mdm1
  • Incidental Mutations
Mice homozygous for a nonsense point mutation exhibit retinal degeneration, abnormal eye electrophysiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020212 Ensembl Gene Model | MGI Sequence Detail 27211 C57BL/6J ±  kb
transcript ENSMUST00000163238 Ensembl | MGI Sequence Detail 3149 Not Applicable  
polypeptide ENSMUSP00000127919 Ensembl | MGI Sequence Detail 718 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    281 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010266 nuclear protein MDM1
  • InterPro Domains
    IPR029136 Nuclear protein MDM1
Molecular
Reagents
less
  • All nucleic 19
    Genomic 4
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12168, MGD-MRK-12171, MGI:2664138
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:8787 Cahilly-Snyder L, et al., Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat Cell Mol Genet. 1987 May;13(3):235-44
  • Latest
    J:228434 Van de Mark D, et al., MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Mol Biol Cell. 2015 Nov 1;26(21):3788-802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory