About   Help   FAQ
Mdm1 Gene Detail
Summary
  • Symbol
    Mdm1
  • Name
    transformed mouse 3T3 cell double minute 1
  • Synonyms
    Mdm-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96951
    NCBI Gene: 17245
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:118141811-118168997 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.65 cM, cytoband C1-C3
  • Mapping Data
    27 experiments
Homology
more
  • Human Ortholog
    MDM1, Mdm1 nuclear protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MDM1, Mdm1 nuclear protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 56890
    neXtProt AC: NX_Q8TC05
    UniProt: Q8TC05

  • Chr Location
    12q15; chr12:68294566-68332381 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9692
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MDM1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Mdm1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a nonsense point mutation exhibit retinal degeneration, abnormal eye electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020212 Ensembl Gene Model | MGI Sequence Detail 27187 C57BL/6J ±  kb
    transcript ENSMUST00000163238 Ensembl | MGI Sequence Detail 2461 Not Applicable  
    polypeptide ENSMUSP00000127919 Ensembl | MGI Sequence Detail 718 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      281 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 4
      cDNA 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12168, MGD-MRK-12171
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:228434 Van de Mark D, et al., MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Mol Biol Cell. 2015 Nov 1;26(21):3788-802

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory