Mdac
Gene Detail

Symbol Name ID

Mdac modifier of Dac MGI:96947

Feature Type

heritable phenotypic marker

Genetic Map

Chromosome 13
Syntenic

Mapping data(2)

Alleles and phenotypes

All alleles(2) : Spontaneous(2)
 

Mice homozygous for the recessive mdac allele alone display no visible phenotype. However, the dominant allele, Mdac, interacts with the Dac gene to suppress the severity of the digit dysmorphology in Dac heterozygotes and embryonic lethality in Dac homozygotes.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (1 annotations)

Process

limb development

Other database links

Entrez Gene

17238

References

(Earliest) J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
(Latest) J:127601 Kano H, et al., Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19034-9
All references(6)

Other accession IDs

MGD-MRK-12161