Mdac Gene Detail

Summary

• Symbol
  Mdac
• Name
  modifier of Dac

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96947
  NCBI Gene: 17238
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr13:56275796-65109572 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, Syntenic
• Mapping Data
  2 experiments

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from multigenic genotypes
  5 phenotype references
  

• All Mutations and Alleles
  2
• Spontaneous
  2
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for the recessive mdac allele alone display no visible phenotype. However, the dominant allele, Mdac, interacts with the Dac gene to suppress the severity of the digit dysmorphology in Dac heterozygotes and embryonic lethality in Dac homozygotes.

Sequences &
Gene Models

• NCBI Gene
  17238

Other
Accession IDs

MGD-MRK-12161

References

• Summaries
  All 6

  Diseases 2

  Phenotypes 5
• Earliest
  J:6607 Chai CK, Dactylaplasia in mice a two-locus model for development anomalies. J Hered. 1981 Jul-Aug;72(4):234-7
• Latest
  J:127601 Kano H, et al., Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19034-9