Ascl1
Gene Detail

Symbol Name ID

Ascl1 achaete-scute complex homolog 1 (Drosophila) MGI:96919

Synonyms

ASH1, bHLHa46, Mash1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

43.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:87490819-87493660 bp, - strand From VEGA annotation of GRCm38   2842 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ascl1

Human homologs

Human Homolog		ASCL1, achaete-scute complex homolog 1 (Drosophila)
NCBI Gene ID		429
neXtProt AC		NX_P50553
Human Synonyms		ASH1, bHLHa46, HASH1, MASH1
Human Chr (Location)		12q23.2; chr12:103351452-103354294 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ASCL1

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous null mutants show impaired development of olfactory, sympathetic, parasympathetic, and enteric ganglia, lung neuroendocrine and adrenal chromaffin cells, and various brain centers, and die at birth with feeding and breathing problems.

 

Gene Ontology (GO) classifications

All GO classifications: (77 annotations)

Process	adrenal chromaffin cell differentiation, carotid body glomus cell differentiation, ...
Component	neuronal cell body, nucleus
Function	bHLH transcription factor binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (349 records)
Data Summary: Results (518)    Tissues (299)    Images (181)
Theiler Stages: 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	33
RNA in situ	472
Northern blot	10
RT-PCR	3

cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(2) cDNA(43) Primer pair(3) Other(12)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024442 (Evidence)
Ensembl Gene Model	ENSMUSG00000020052 (Evidence)
Entrez Gene	17172 (Evidence)
UniGene	136217
DFCI	TC1582731, TC1615565
DoTS	DT.487773, DT.97333696
NIA Mouse Gene Index	U032097, U061902
Consensus CDS Project	CCDS24101.1
International Mouse Knockout Project Status	Ascl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024442	VEGA Gene Model | MGI Sequence Detail	2842	C57BL/6J
transcript	OTTMUST00000059929	VEGA | MGI Sequence Detail	2481	Not Applicable
polypeptide	OTTMUSP00000029198	VEGA | MGI Sequence Detail	231	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015660	Achaete-scute transcription factor-related
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000004362	achaete-scute 1

References

(Earliest) J:36275 Lo LC, et al., Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes Dev. 1991 Sep;5(9):1524-37
(Latest) J:194893 Yu K, et al., Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
All references(439)

Other accession IDs

MGD-MRK-12119, MGI:2143541