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Ascl1
Gene Detail
 Symbol
Name
ID
Ascl1
achaete-scute complex homolog 1 (Drosophila)
MGI:96919
Synonyms ASH1, bHLHa46, Mash1
Feature Type protein coding gene
Genetic Map
Chromosome 10
43.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:87490819-87493660 bp, - strand
From VEGA annotation of GRCm38

  2842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ascl1

Human
homologs
Human Homolog ASCL1, achaete-scute family bHLH transcription factor 1
NCBI Gene ID 429
neXtProt AC  NX_P50553
Human Synonyms  ASH1, bHLHa46, HASH1, MASH1
Human Chr (Location)  12q23.2; chr12:102957674-102960516 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ASCL1
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Homozygous null mutants show impaired development of olfactory, sympathetic, parasympathetic, and enteric ganglia, lung neuroendocrine and adrenal chromaffin cells, and various brain centers, and die at birth with feeding and breathing problems.
 
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process adrenal chromaffin cell differentiation, carotid body glomus cell differentiation, ...
Component neuronal cell body, nucleus
Function bHLH transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (376 records)
Data Summary: Results (592)    Tissues (312)    Images (226)
Theiler Stages: 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 39
RNA in situ 540
Northern blot 10
RT-PCR 3
cDNA source data(34)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(63) Genomic(2) cDNA(45) Primer pair(3) Other(13)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024442 (Evidence)
Ensembl Gene ModelENSMUSG00000020052 (Evidence)
Entrez Gene17172 (Evidence)
UniGene136217
DFCITC1582731, TC1615565
DoTSDT.487773, DT.97333696
NIA Mouse Gene IndexU032097, U061902
Consensus CDS ProjectCCDS24101.1
International Mouse Knockout Project StatusAscl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024442 VEGA Gene Model | MGI Sequence Detail 2842 C57BL/6J ±  kb
transcript OTTMUST00000059929 VEGA | MGI Sequence Detail 2481 Not Applicable 
polypeptide OTTMUSP00000029198 VEGA | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015660 Achaete-scute transcription factor-related
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000004362 achaete-scute homolog 1
References (Earliest) J:36275 Lo LC, et al., Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes Dev. 1991 Sep;5(9):1524-37
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(472)
Other
accession IDs
MGD-MRK-12119, MGI:2143541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory