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Mas1 Gene Detail
Summary
  • Symbol
    Mas1
  • Name
    MAS1 oncogene
  • Synonyms
    Mas-1, MasR, Mas receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96918
    NCBI Gene: 17171
  • Gene Overview
    MyGene.info: MAS1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:12841079-12868143 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27065 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.69 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    MAS1, MAS1 proto-oncogene, G protein-coupled receptor
  • Vertebrate Orthologs
    12
  • Human Ortholog
    MAS1, MAS1 proto-oncogene, G protein-coupled receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAS, MGRA
  • Links
    NCBI Gene ID: 4142
    neXtProt AC: NX_P04201
    UniProt: P04201

  • Chr Location
    6q25.3; chr6:159906942-159908076 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show enhanced long term potentiation and higher levels of anxiety. They are otherwise normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034919 VEGA Gene Model | MGI Sequence Detail 27065 C57BL/6J ±  kb
    transcript OTTMUST00000088777 VEGA | MGI Sequence Detail 2401 Not Applicable  
    polypeptide OTTMUSP00000048428 VEGA | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      90 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 7
      cDNA 10
      Primer pair 1
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12117, MGD-MRK-12118
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:902 Cebra-Thomas JA, et al., Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting [published erratum appears in Genomics 1992 Sep;14(1):208]. Genomics. 1992 Jun;13(2):444-6
    • Latest
      J:255910 Sobrino A, et al., Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation. Biochem Pharmacol. 2017 Apr 1;129:67-72

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory