Maf
Gene Detail

Symbol Name ID

Maf avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog MGI:96909

Synonyms

2810401A20Rik, A230108G15Rik, c-maf

Feature Type

protein coding gene

Genetic Map

Chromosome 8

62.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr8:115682942-115707794 bp, - strand From VEGA annotation of GRCm38   24853 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74552  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: maf transforming protein
Gene Tree: Maf

Human homologs

Human Homolog		MAF, v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
NCBI Gene ID		4094
neXtProt AC		NX_O75444
Human Synonyms		CCA4, c-MAF
Human Chr (Location)		16q22-q23; chr16:79627745-79634622 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAF

Alleles and phenotypes

All alleles(7) : Targeted(5) Chemically induced(1) Radiation induced(1)
 

Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.

 
Human Diseases Modeled Using Mouse Maf (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cell development, cytokine production, ...
Component	cytoplasm, nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (46 records)
Data Summary: Results (208)    Tissues (79)    Images (38)
Theiler Stages: 15, 18, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	187
In situ reporter (knock in)	10
RT-PCR	8

cDNA source data(17)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(17) Primer pair(3) Other(2)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000024922 (Evidence)
Ensembl Gene Model	ENSMUSG00000055435 (Evidence)
Entrez Gene	17132 (Evidence)
DFCI	TC1585697, TC1598781, TC1613873, TC1652786
DoTS	DT.101227673, DT.110899502, DT.40169651, DT.523436, DT.55239338, DT.87068516, DT.91332630
NIA Mouse Gene Index	U252694
Consensus CDS Project	CCDS40486.1
International Mouse Knockout Project Status	Maf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024922	VEGA Gene Model | MGI Sequence Detail	24853	C57BL/6J
transcript	OTTMUST00000061393	VEGA | MGI Sequence Detail	3223	Not Applicable
polypeptide	OTTMUSP00000030104	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(46) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR013592	Maf transcription factor, N-terminal
InterPro	IPR024874	Transcription factor Maf
Protein Ontology	PR:000010045	transcription factor Maf

References

(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:188993 Ciofani M, et al., A validated regulatory network for th17 cell specification. Cell. 2012 Oct 12;151(2):289-303
All references(109)

Other accession IDs

MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997