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Lamp1
Gene Detail
Symbol

Name
ID
Lamp1
lysosomal-associated membrane protein 1
MGI:96745
Synonyms
CD107a, Lamp-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:13159135-13175338 bp, + strand
From Ensembl annotation of GRCm38

  16204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LAMP1
Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp1

Human
homologs
LAMP1, lysosomal-associated membrane protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3916
neXtProt AC: NX_P11279

Human Synonyms: CD107a, LAMPA, LGP120

Human Chr (Location): 13q34; chr13:113297121-113323431 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Interactions
Lamp1 interacts with 126 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process autophagic cell death, establishment of protein localization to organelle, ...
Component alveolar lamellar body, cell surface, ...
Function enzyme binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (93)    Tissues (24)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 82
cDNA source data(475)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamp1    NEW 
Molecular
reagents
All nucleic(478) cDNA(475) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031447 (Evidence)
Entrez Gene 16783 (Evidence)
UniGene 16716
DFCI TC1574007, TC1655738, TC1719604
NIA Mouse Gene Index U009101
Consensus CDS Project CCDS22106.1
International Mouse Phenotyping Consortium Status Lamp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031447 Ensembl Gene Model | MGI Sequence Detail 16204 C57BL/6J ±  kb
transcript ENSMUST00000033824 Ensembl | MGI Sequence Detail 2255 Not Applicable 
polypeptide ENSMUSP00000033824 Ensembl | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002000 Lysosome-associated membrane glycoprotein
InterPro IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology PR:000002060 lysosome-associated membrane glycoprotein 1
References
(Earliest) J:8849 Green SA, et al., Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. J Cell Biol. 1987 Sep;105(3):1227-40
(Latest) J:216506 Tholen M, et al., Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 2014;5:4931
All references(131)
Other
accession IDs
MGD-MRK-11740, MGD-MRK-11742, MGI:2142479

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory