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Lamp1
Gene Detail
 Symbol
Name
ID
Lamp1
lysosomal-associated membrane protein 1
MGI:96745
Synonyms CD107a, Lamp-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:13159135-13175338 bp, + strand
From NCBI annotation of GRCm38

  16204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp1

Human
homologs
Human Homolog LAMP1, lysosomal-associated membrane protein 1
NCBI Gene ID 3916
neXtProt AC  NX_P11279
Human Synonyms  CD107a, LAMPA, LGP120
Human Chr (Location)  13q34; chr13:113297154-113323426 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Interactions
Lamp1 interacts with 126 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process autophagic cell death, establishment of protein localization to organelle, ...
Component alveolar lamellar body, cell surface, ...
Function enzyme binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (90)    Tissues (23)    Images (23)
Theiler Stages: 10, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 82
cDNA source data(475)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(478) cDNA(475) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031447 (Evidence)
Entrez Gene16783 (Evidence)
UniGene16716
DFCITC1574007, TC1655738, TC1719604
NIA Mouse Gene IndexU009101
Consensus CDS ProjectCCDS22106.1
International Mouse Knockout Project StatusLamp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16783 NCBI Gene Model | MGI Sequence Detail 16204 C57BL/6J ±  kb
transcript NM_010684 RefSeq | MGI Sequence Detail 2265 C57BL/6 
polypeptide P11438 UniProt | EBI | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(2) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002000 Lysosome-associated membrane glycoprotein
InterPro IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology PR:000002060 lysosome-associated membrane glycoprotein 1
Graphical View of Protein Domain Structure
References (Earliest) J:8849 Green SA, et al., Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. J Cell Biol. 1987 Sep;105(3):1227-40
(Latest) J:203507 White C, et al., HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013 Feb 5;17(2):261-70
All references(126)
Other
accession IDs
MGD-MRK-11740, MGD-MRK-11742, MGI:2142479

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory