Lamp1
Gene Detail

Symbol Name ID

Lamp1 lysosomal-associated membrane protein 1 MGI:96745

Synonyms

CD107a, Lamp-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:13159135-13175338 bp, + strand From NCBI annotation of GRCm38   16204 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Lamp1

Human homologs

Human Homolog		LAMP1, lysosomal-associated membrane protein 1
NCBI Gene ID		3916
neXtProt AC		NX_P11279
Human Synonyms		CD107a, LAMPA, LGP120
Human Chr (Location)		13q34; chr13:113951469-113977741 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(9)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	autophagic cell death, spermatogenesis
Component	alveolar lamellar body, cell surface, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (89)    Tissues (22)    Images (21)
Theiler Stages: 10, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	82

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031447 (Evidence)
Entrez Gene	16783 (Evidence)
DFCI	TC1574007, TC1655738, TC1719604
NIA Mouse Gene Index	U009101
Consensus CDS Project	CCDS22106.1
International Mouse Knockout Project Status	Lamp1

Sequences

Length	Strain/Species
genomic	16783	NCBI Gene Model | MGI Sequence Detail	16204	C57BL/6J
transcript	NM_010684	RefSeq | MGI Sequence Detail	2265	C57BL/6
polypeptide	P11438	UniProt | EBI | MGI Sequence Detail	406	Not Applicable

All sequences(61) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002000	Lysosome-associated membrane glycoprotein
InterPro	IPR018134	Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology	PR:000002060	lysosome-associated membrane glycoprotein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:8849 Green SA, et al., Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. J Cell Biol. 1987 Sep;105(3):1227-40
(Latest) J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
All references(110)

Other accession IDs

MGD-MRK-11740, MGD-MRK-11742, MGI:2142479