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Lamp1 Gene Detail
Summary
  • Symbol
    Lamp1
  • Name
    lysosomal-associated membrane protein 1
  • Synonyms
    CD107a, Lamp-1, Perk
  • Feature Type
    protein coding gene
  • IDs
    MGI:96745
    NCBI Gene: 16783
  • Gene Overview
    MyGene.info: LAMP1
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13159161-13175338 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96745
protein coding gene Chr8:13159161-13175338 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033373
protein coding gene Chr8:10484849-10501811 (+)
A/J MGP_AJ_G0033353
protein coding gene Chr8:10111998-10128285 (+)
AKR/J MGP_AKRJ_G0033284
protein coding gene Chr8:10377406-10393525 (+)
BALB/cJ MGP_BALBcJ_G0033354
protein coding gene Chr8:10244521-10261255 (+)
C3H/HeJ MGP_C3HHeJ_G0033067
protein coding gene Chr8:10592514-10610078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033866
protein coding gene Chr8:10850178-10869696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030835
protein coding gene Chr8:9614329-9631598 (+)
CAST/EiJ MGP_CASTEiJ_G0032389
protein coding gene Chr8:10344274-10360493 (+)
CBA/J MGP_CBAJ_G0033040
protein coding gene Chr8:11303127-11322004 (+)
DBA/2J MGP_DBA2J_G0033193
protein coding gene Chr8:10062106-10078279 (+)
FVB/NJ MGP_FVBNJ_G0033142
protein coding gene Chr8:10073590-10090006 (+)
LP/J MGP_LPJ_G0033287
protein coding gene Chr8:10399456-10415764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033176
protein coding gene Chr8:11548441-11565799 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033883
protein coding gene Chr8:10440870-10457591 (+)
PWK/PhJ MGP_PWKPhJ_G0032102
protein coding gene Chr8:10109879-10126263 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031944
protein coding gene Chr8:10334317-10350309 (+)
WSB/EiJ MGP_WSBEiJ_G0032505
protein coding gene Chr8:10473123-10489305 (+)



Homology
more
  • Human Ortholog
    LAMP1, lysosomal associated membrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LAMP1, lysosomal associated membrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD107a, LAMPA, LGP120
  • Links
    NCBI Gene ID: 3916
    neXtProt AC: NX_P11279
    UniProt: P11279

  • Chr Location
    13q34; chr13:113297154-113323431 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16783 NCBI Gene Model | MGI Sequence Detail 16178 C57BL/6J ±  kb
transcript NM_001317353 RefSeq | MGI Sequence Detail 2242 C57BL/6  
polypeptide P11438 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002060 lysosome-associated membrane glycoprotein 1
  • PDB
  • InterPro Domains
    IPR002000 Lysosome-associated membrane glycoprotein
    IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Molecular
Reagents
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  • All nucleic 479
    cDNA 476
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11740, MGD-MRK-11742, MGI:2142479
References
more
  • Summaries
    All 166
    Developmental Gene Expression 45
    Gene Ontology 43
    Phenotypes 11
  • Earliest
    J:8849 Green SA, et al., Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. J Cell Biol. 1987 Sep;105(3):1227-40
  • Latest
    J:273177 Gerber H, et al., The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019 Jan 31;7(1):13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory