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Krt19 Gene Detail
Summary
  • Symbol
    Krt19
  • Name
    keratin 19
  • Synonyms
    cytokeratin19, cytokeratin 19, cytokeratin-19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344
  • Feature Type
    protein coding gene
  • IDs
    MGI:96693
    NCBI Gene: 16669
  • Gene Overview
    MyGene.info: KRT19
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100140810-100145926 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.42 cM
  • Mapping Data
    9 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96693
protein coding gene Chr11:100140810-100148665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019143
protein coding gene Chr11:102889238-102897097 (-)
A/J MGP_AJ_G0019111
protein coding gene Chr11:98546453-98554672 (-)
AKR/J MGP_AKRJ_G0019080
protein coding gene Chr11:101591190-101599049 (-)
BALB/cJ MGP_BALBcJ_G0019085
protein coding gene Chr11:99062960-99070790 (-)
C3H/HeJ MGP_C3HHeJ_G0018894
protein coding gene Chr11:101790503-101798358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019534
protein coding gene Chr11:106056636-106064493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017161
protein coding gene Chr11:96001166-96009090 (-)
CAST/EiJ MGP_CASTEiJ_G0018448
protein coding gene Chr11:102771023-102778653 (-)
CBA/J MGP_CBAJ_G0018863
protein coding gene Chr11:110492052-110499882 (-)
DBA/2J MGP_DBA2J_G0018976
protein coding gene Chr11:98121541-98129400 (-)
FVB/NJ MGP_FVBNJ_G0018965
protein coding gene Chr11:97622655-97631685 (-)
LP/J MGP_LPJ_G0019044
protein coding gene Chr11:103427705-103436059 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018996
protein coding gene Chr11:110116327-110124169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019572
protein coding gene Chr11:101968696-101976526 (-)
PWK/PhJ MGP_PWKPhJ_G0018211
protein coding gene Chr11:99152740-99161063 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018003
protein coding gene Chr11:101669886-101679171 (-)
WSB/EiJ MGP_WSBEiJ_G0018497
protein coding gene Chr11:101936445-101944277 (-)



Homology
more
  • Human Ortholog
    KRT19, keratin 19
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KRT19, keratin 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK19, K19, K1CS
  • Links
    NCBI Gene ID: 3880
    neXtProt AC: NX_P08727
    UniProt: P08727

  • Chr Location
    17q21.2; chr17:41523617-41528389 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    50 phenotypes from multigenic genotypes
    2 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16669 NCBI Gene Model | MGI Sequence Detail 5117 C57BL/6J ±  kb
transcript NM_008471 RefSeq | MGI Sequence Detail 1396 C57BL/6  
polypeptide P19001 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 309
    Genomic 10
    cDNA 295
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11633, MGD-MRK-11648, MGI:2144260
References
more
  • Summaries
    All 199
    Developmental Gene Expression 100
    Gene Ontology 10
    Phenotypes 65
  • Earliest
    J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
  • Latest
    J:272586 Suzuki T, et al., Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory