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Krt19 Gene Detail
Summary
  • Symbol
    Krt19
  • Name
    keratin 19
  • Synonyms
    cytokeratin19, cytokeratin 19, cytokeratin-19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344
  • Feature Type
    protein coding gene
  • IDs
    MGI:96693
    NCBI Gene: 16669
  • Gene Overview
    MyGene.info: KRT19
Location & Maps
more
  • Sequence Map
    Chr11:100140810-100148665 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7856 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.42 cM
  • Mapping Data
    9 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    KRT19, keratin 19
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KRT19, keratin 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK19, K19, K1CS
  • Links
    NCBI Gene ID: 3880
    neXtProt AC: NX_P08727

  • Chr Location
    17q21.2; chr17:41523617-41528389 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    40 phenotypes from multigenic genotypes
    2 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    7
  • Genomic Mutations
    1 involving Krt19
  • Incidental Mutations
Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002545 VEGA Gene Model | MGI Sequence Detail 7856 C57BL/6J ±  kb
transcript OTTMUST00000004972 VEGA | MGI Sequence Detail 1576 Not Applicable  
polypeptide OTTMUSP00000002396 VEGA | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    93 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 309
    Genomic 10
    cDNA 295
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11633, MGD-MRK-11648, MGI:2144260
References
more
  • Summaries
    All 156
    Developmental Gene Expression 76
    Gene Ontology 9
    Phenotypes 53
  • Earliest
    J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
  • Latest
    J:233310 Wuidart A, et al., Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev. 2016 Jun 1;30(11):1261-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory