Krt19
Gene Detail

Symbol Name ID

Krt19 keratin 19 MGI:96693

STS

D11Mit59

Synonyms

cytokeratin19, cytokeratin 19, cytokeratin-19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr11:100140810-100148665 bp, - strand From VEGA annotation of GRCm38   7856 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Krt19

Human homologs

Human Homolog		KRT19, keratin 19
NCBI Gene ID		3880
neXtProt AC		NX_P08727
Human Synonyms		CK19, K19, K1CS
Human Chr (Location)		17q21.2; chr17:39679869-39684641 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell differentiation involved in embryonic placenta development, sarcomere organization
Component	cell periphery, costamere, ...
Function	protein complex binding, structural constituent of muscle, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (361)    Tissues (80)    Images (42)
Theiler Stages: 7, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	337
Northern blot	4
RT-PCR	6
RNase protection	11

cDNA source data(296)
External Resources: GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(309) Genomic(10) cDNA(296) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002545 (Evidence)
Ensembl Gene Model	ENSMUSG00000020911 (Evidence)
Entrez Gene	16669 (Evidence)
UniGene	439699
DFCI	TC1572673
DoTS	DT.60141861
NIA Mouse Gene Index	U013334
Consensus CDS Project	CCDS25411.1
International Mouse Knockout Project Status	Krt19

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002545	VEGA Gene Model | MGI Sequence Detail	7856	C57BL/6J
transcript	OTTMUST00000004972	VEGA | MGI Sequence Detail	1576	Not Applicable
polypeptide	OTTMUSP00000002396	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000009459	keratin, type I cytoskeletal 19

References

(Earliest) J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
(Latest) J:193313 Takase HM, et al., FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013 Jan 15;27(2):169-81
All references(121)

Other accession IDs

MGD-MRK-11633, MGD-MRK-11648, MGI:2144260