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Krt19
Gene Detail
 Symbol
Name
ID
Krt19
keratin 19
MGI:96693
STS D11Mit59
Synonyms cytokeratin19, cytokeratin 19, cytokeratin-19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr11:100140810-100148665 bp, - strand
From VEGA annotation of GRCm38

  7856 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Krt19

Human
homologs
Human Homolog KRT19, keratin 19
NCBI Gene ID 3880
neXtProt AC  NX_P08727
Human Synonyms  CK19, K19, K1CS
Human Chr (Location)  17q21.2; chr17:41523617-41528389 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.
 
Phenotype Images(2)
Interactions
Krt19 interacts with 21 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell differentiation involved in embryonic placenta development, sarcomere organization
Component cell periphery, costamere, ...
Function protein complex binding, structural constituent of muscle, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (360)    Tissues (79)    Images (42)
Theiler Stages: 7, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 337
Northern blot 4
RT-PCR 6
RNase protection 10
cDNA source data(295)
External Resources: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(308) Genomic(10) cDNA(295) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002545 (Evidence)
Ensembl Gene ModelENSMUSG00000020911 (Evidence)
Entrez Gene16669 (Evidence)
UniGene439699
DFCITC1572673
DoTSDT.60141861
NIA Mouse Gene IndexU013334
Consensus CDS ProjectCCDS25411.1
International Mouse Knockout Project StatusKrt19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002545 VEGA Gene Model | MGI Sequence Detail 7856 C57BL/6J ±  kb
transcript OTTMUST00000004972 VEGA | MGI Sequence Detail 1576 Not Applicable 
polypeptide OTTMUSP00000002396 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009459 keratin, type I cytoskeletal 19
References (Earliest) J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
(Latest) J:210472 Zito G, et al., Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nat Commun. 2014;5:3543
All references(134)
Other
accession IDs
MGD-MRK-11633, MGD-MRK-11648, MGI:2144260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory