In(15)4H Cytogenetic Marker Detail

Summary

• Symbol
  In(15)4H
• Name
  inversion, Chr 15, Harwell 4
• Synonyms
  Koa, koala

• Feature Type
  chromosomal inversion
• IDs
  MGI:96678
  NCBI Gene: 109551

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 15, Syntenic
• Mapping Data
  3 experiments

Human Diseases

• Diseases
  1 with In(15)4H mouse models

Human Disease

Mouse Models

Ambras type hypertrichosis universalis congenita

IDs

Ambras type hypertrichosis universalis congenita      

DOID:0111060
ICD10CM:Q84.2
MESH:C536605
OMIM:145701
ORDO:1023

View 2 models

Mouse Models

Human Disease Modeled: Ambras type hypertrichosis universalis congenita

Allelic Composition	Genetic Background	Reference	Phenotypes
In(15)4H/In(15)4H	involves: C3H/HeH	J:141036	View
In(15)4H/+	involves: C3H/HeH	J:141036	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 1 allele in 2 genetic backgrounds
  6 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  1 strains or lines available

Homozygotes have long hair on the ears and a bushy muzzle. They have a broader head, open eyes at birth, smaller body size and smaller litters. Heterozygotes also have longer hair on the ears and a bushy muzzle.

Sequences &
Gene Models

• NCBI Gene
  109551

Other
Accession IDs

MGD-MRK-11594

References

• Summaries
  All 9

  Diseases 1

  Phenotypes 6
• Earliest
  J:103253 Peters J, et al., Koala, Koa, is associated with an inversion on mouse Chromosome 15. Genet Res. 1992;59:237-8 (Abstract)
• Latest
  J:155838 Katayama K, et al., Characterization of the chromosomal inversion associated with the Koa mutation in the mouse revealed the cause of skeletal abnormalities. BMC Genet. 2009;10:60