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Kcna4
Gene Detail
Symbol

Name
ID
Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
MGI:96661
Synonyms
Kv1.4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
56.12 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:107290639-107298502 bp, + strand
From VEGA annotation of GRCm38

  7864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, KCNA4 subunit
Gene Tree: Kcna4

Human
homologs
Human Homolog KCNA4, potassium voltage-gated channel, shaker-related subfamily, member 4
NCBI Gene ID 3739
neXtProt AC  NX_P22459
Human Synonyms  HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2
Human Chr (Location)  11p14; chr11:30009741-30017030 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, fertile and grossly normal; however, a small subset of mutants exhibit spontaneous seizure activity.
 
Interactions
Kcna4 interacts with 291 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (22)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 14
RT-PCR 6
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015041 (Evidence)
Ensembl Gene ModelENSMUSG00000042604 (Evidence)
Entrez Gene16492 (Evidence)
UniGene142718
DFCITC1586016
DoTSDT.101365281
NIA Mouse Gene IndexU002213
Consensus CDS ProjectCCDS16505.1
International Mouse Knockout Project StatusKcna4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015041 VEGA Gene Model | MGI Sequence Detail 7864 C57BL/6J ±  kb
transcript OTTMUST00000035721 VEGA | MGI Sequence Detail 4792 Not Applicable 
polypeptide OTTMUSP00000016013 VEGA | MGI Sequence Detail 654 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR020467 Potassium channel, voltage dependent, Kv1.4
InterPro IPR012897 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000683 voltage-gated potassium channel alpha subunit KCNA4
References
(Earliest) J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
(Latest) J:200210 Carrasquillo Y, et al., A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. J Physiol. 2012 Aug 15;590(Pt 16):3877-90
All references(51)
Other
accession IDs
MGD-MRK-11565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory