About   Help   FAQ
Kcna4 Gene Detail
Summary
  • Symbol
    Kcna4
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 4
  • Synonyms
    Kv1.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96661
    NCBI Gene: 16492
  • Gene Overview
    MyGene.info: KCNA4
Location & Maps
more
  • Sequence Map
    Chr2:107290639-107298502 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7864 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 56.12 cM, cytoband E
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    KCNA4, potassium voltage-gated channel subfamily A member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNA4, potassium voltage-gated channel subfamily A member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2
  • Links
    NCBI Gene ID: 3739
    neXtProt AC: NX_P22459

  • Chr Location
    11p14.1; chr11:30009741-30017030 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Kcna4
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable, fertile and grossly normal; however, a small subset of mutants exhibit spontaneous seizure activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015041 VEGA Gene Model | MGI Sequence Detail 7864 C57BL/6J ±  kb
transcript OTTMUST00000035721 VEGA | MGI Sequence Detail 4792 Not Applicable  
polypeptide OTTMUSP00000016013 VEGA | MGI Sequence Detail 654 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000683 voltage-gated potassium channel alpha subunit KCNA4
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003972 Potassium channel, voltage dependent, Kv1
    IPR020467 Potassium channel, voltage dependent, Kv1.4
    IPR012897 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
less
  • All nucleic 10
    Genomic 3
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11565
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
  • Latest
    J:232973 Hirst CS, et al., Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory