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Jak2
Gene Detail
Symbol

Name
ID
Jak2
Janus kinase 2
MGI:96629
Synonyms
C81284
Feature Type
protein coding gene
Genetic Map
Chromosome 19
23.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr19:29251828-29313080 bp, + strand
From Ensembl annotation of GRCm38

  61253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: JAK2
Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak2

Human
homologs
JAK2, Janus kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3717
neXtProt AC: NX_O60674

Human Synonyms: JTK10, THCYT3

Human Chr (Location): 9p24; chr9:4985245-5128183 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human JAK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(15) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null mutations die during midgestation due to a failure of erythropoieses. Mice expressing a conditional allele activated in mammary tissue exhibit lactation deficiency due to impaired alveologenesis. Mice homozygous for a knock-in allele exhibit myeloproliferative neoplasm.
 
Human Diseases Modeled in Mice Using Jak2 (3)    Mutations Annotated to Human Diseases (8)   
Interactions
Jak2 interacts with 245 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (14 records)
Data Summary: Results (250)    Tissues (72)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 200
Western blot 3
RT-PCR 46
cDNA source data(87)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase jak2 ; ZFIN jak2a, jak2b    NEW 
Molecular
reagents
All nucleic(93) Genomic(2) cDNA(87) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024789 (Evidence)
Entrez Gene 16452 (Evidence)
UniGene 275839
DFCI TC1580801, TC1620219, TC1640491, TC1682205
DoTS DT.101735148, DT.532402, DT.94255102, DT.94255103
NIA Mouse Gene Index U043720
EC 2.7.10.2
PDB 2HDX, 4GL9
Consensus CDS Project CCDS37950.1
International Mouse Phenotyping Consortium Status Jak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024789 Ensembl Gene Model | MGI Sequence Detail 61253 C57BL/6J ±  kb
transcript ENSMUST00000065796 Ensembl | MGI Sequence Detail 5030 Not Applicable 
polypeptide ENSMUSP00000064394 Ensembl | MGI Sequence Detail 1132 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020693 Tyrosine-protein kinase, non-receptor Jak2
InterPro IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology PR:000009197 tyrosine-protein kinase JAK2
References
(Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:222995 Meyer SC, et al., CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell. 2015 Jul 13;28(1):15-28
All references(192)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-11517, MGI:2147569, MGI:2147795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory