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Jak1
Gene Detail
 Symbol
Name
ID
Jak1
Janus kinase 1
MGI:96628
Synonyms C130039L05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
46.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:101152367-101265282 bp, - strand
From VEGA annotation of GRCm38

  112916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak1

Human
homologs
Human Homolog JAK1, Janus kinase 1
NCBI Gene ID 3716
neXtProt AC  NX_P23458
Human Synonyms  JAK1A, JAK1B, JTK3
Human Chr (Location)  1p32.3-p31.3; chr1:64833223-64966910 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die within the first 24 hours after birth.
 
Human Diseases Modeled Using Mouse Jak1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Jak1 interacts with 203 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cytokine-mediated signaling pathway, enzyme linked receptor protein signaling pathway, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, CCR5 chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (181)    Tissues (73)    Images (37)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 89
RT-PCR 92
cDNA source data(310)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(313) Genomic(1) cDNA(310) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000008208 (Evidence)
Ensembl Gene ModelENSMUSG00000028530 (Evidence)
Entrez Gene16451 (Evidence)
UniGene289657
DFCITC1572246, TC1599046, TC1601989, TC1612064, TC1615753
NIA Mouse Gene IndexU025300
EC2.7.10.2
Consensus CDS ProjectCCDS18393.1
International Mouse Knockout Project StatusJak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008208 VEGA Gene Model | MGI Sequence Detail 112916 C57BL/6J ±  kb
transcript OTTMUST00000018649 VEGA | MGI Sequence Detail 4906 Not Applicable 
polypeptide OTTMUSP00000008566 VEGA | MGI Sequence Detail 1153 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(671 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020776 Tyrosine-protein kinase, non-receptor Jak1
InterPro IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology PR:000009196 tyrosine-protein kinase JAK1
References (Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:201029 Perez-Rivero G, et al., Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naive T-cell homing. Eur J Immunol. 2013 Jul;43(7):1745-57
All references(98)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11516, MGI:2140180, MGI:2443062

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory