Jak1
Gene Detail

Symbol Name ID

Jak1 Janus kinase 1 MGI:96628

Synonyms

C130039L05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

46.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:101152367-101265282 bp, - strand From VEGA annotation of GRCm38   112916 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak1

Human homologs

Human Homolog		JAK1, Janus kinase 1
NCBI Gene ID		3716
neXtProt AC		NX_P23458
Human Synonyms		JAK1A, JAK1B, JTK3
Human Chr (Location)		1p32.3-p31.3; chr1:65298906-65432187 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for disruption of this gene die within the first 24 hours after birth.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cytokine-mediated signaling pathway, enzyme linked receptor protein signaling pathway, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, CCR5 chemokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (181)    Tissues (73)    Images (37)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	89
RT-PCR	92

cDNA source data(271)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(274) Genomic(1) cDNA(271) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000008208 (Evidence)
Ensembl Gene Model	ENSMUSG00000028530 (Evidence)
Entrez Gene	16451 (Evidence)
UniGene	289657
DFCI	TC1572246, TC1599046, TC1601989, TC1612064, TC1615753
NIA Mouse Gene Index	U025300
EC	2.7.10.2
Consensus CDS Project	CCDS18393.1
International Mouse Knockout Project Status	Jak1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008208	VEGA Gene Model | MGI Sequence Detail	112916	C57BL/6J
transcript	OTTMUST00000018649	VEGA | MGI Sequence Detail	4906	Not Applicable
polypeptide	OTTMUSP00000008566	VEGA | MGI Sequence Detail	1153	Not Applicable

All sequences(73) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(547 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019748	FERM central domain
InterPro	IPR000299	FERM domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR020776	Tyrosine-protein kinase, non-receptor Jak1
InterPro	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology	PR:000009196	tyrosine-protein kinase JAK1

References

(Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:187745 Doles J, et al., Age-associated inflammation inhibits epidermal stem cell function. Genes Dev. 2012 Oct 1;26(19):2144-53
All references(96)

Other accession IDs

MGD-MRK-11516, MGI:2140180, MGI:2443062