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Itgb7
Gene Detail
Symbol

Name
ID
Itgb7
integrin beta 7
MGI:96616
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:102215995-102231935 bp, - strand
From VEGA annotation of GRCm38

  15941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGB7
Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb7

Human
homologs
ITGB7, integrin, beta 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3695
neXtProt AC: NX_P26010

Human Chr (Location): 12q13.13; chr12:53191318-53207310 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(38) Radiation induced(1) Targeted(7)
Genomic Mutations involving Itgb7 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration
 
Phenotype Images(2)
Interactions
Itgb7 interacts with 34 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell adhesion, cell-matrix adhesion, ...
Component cell surface, extracellular exosome, ...
Function cell adhesion molecule binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (17)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itgb7    NEW 
Molecular
reagents
All nucleic(34) Genomic(3) cDNA(31)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030863 (Evidence)
Ensembl Gene Model ENSMUSG00000001281 (Evidence)
Entrez Gene 16421 (Evidence)
UniGene 58
DFCI TC1580784, TC1696234
DoTS DT.101360593, DT.101367522, DT.492105
NIA Mouse Gene Index U036692
Consensus CDS Project CCDS49740.1
International Mouse Phenotyping Consortium Status Itgb7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030863 VEGA Gene Model | MGI Sequence Detail 15941 C57BL/6J ±  kb
transcript OTTMUST00000076379 VEGA | MGI Sequence Detail 2674 Not Applicable 
polypeptide OTTMUSP00000040198 VEGA | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR015437 Integrin beta-7 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009143 integrin beta-7
References
(Earliest) J:32336 Yuan Q, et al., Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine. Biochem Biophys Res Commun. 1991 May 15;176(3):1443-9
(Latest) J:209989 Davila SJ, et al., Integrin alpha4beta1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J Immunol. 2014 May 1;192(9):4284-93
All references(99)
Other
accession IDs
MGD-MRK-11495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory