Itgb7
Gene Detail

Symbol Name ID

Itgb7 integrin beta 7 MGI:96616

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr15:102215995-102231935 bp, - strand From VEGA annotation of GRCm38   15941 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb7

Human homologs

Human Homolog		ITGB7, integrin, beta 7
NCBI Gene ID		3695
neXtProt AC		NX_P26010
Human Chr (Location)		12q13.13; chr12:53585107-53601000 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(45) : Targeted(7) Gene trapped(38)
 

Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell adhesion, cell-matrix adhesion, ...
Component	integral to membrane, integrin complex, ...
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (17)    Images (11)
Theiler Stages: 17, 20, 23

Assay Type	Results
RNA in situ	24

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(3) cDNA(31)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030863 (Evidence)
Ensembl Gene Model	ENSMUSG00000001281 (Evidence)
Entrez Gene	16421 (Evidence)
UniGene	58
DFCI	TC1580784, TC1696234
DoTS	DT.101360593, DT.101367522, DT.492105
NIA Mouse Gene Index	U036692
Consensus CDS Project	CCDS49740.1
International Mouse Knockout Project Status	Itgb7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030863	VEGA Gene Model | MGI Sequence Detail	15941	C57BL/6J
transcript	OTTMUST00000076379	VEGA | MGI Sequence Detail	2674	Not Applicable
polypeptide	OTTMUSP00000040198	VEGA | MGI Sequence Detail	806	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013111	EGF, extracellular
InterPro	IPR015437	Integrin beta-7 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009143	integrin beta-7

References

(Earliest) J:32336 Yuan Q, et al., Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine. Biochem Biophys Res Commun. 1991 May 15;176(3):1443-9
(Latest) J:188011 Schippers A, et al., beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses. Clin Immunol. 2012 Aug;144(2):87-97
All references(93)

Other accession IDs

MGD-MRK-11495