About   Help   FAQ
Itgb7
Gene Detail
 Symbol
Name
ID
Itgb7
integrin beta 7
MGI:96616
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:102215995-102231935 bp, - strand
From VEGA annotation of GRCm38

  15941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb7

Human
homologs
Human Homolog ITGB7, integrin, beta 7
NCBI Gene ID 3695
neXtProt AC  NX_P26010
Human Chr (Location)  12q13.13; chr12:53191318-53207307 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(38) Radiation induced(1) Targeted(7)
Genomic Mutations involving Itgb7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration
 
Interactions
Itgb7 interacts with 34 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell adhesion, cell-matrix adhesion, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (24)    Tissues (17)    Images (11)
Theiler Stages: 17, 20, 23
Assay TypeResults
RNA in situ 24
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(3) cDNA(31)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030863 (Evidence)
Ensembl Gene ModelENSMUSG00000001281 (Evidence)
Entrez Gene16421 (Evidence)
UniGene58
DFCITC1580784, TC1696234
DoTSDT.101360593, DT.101367522, DT.492105
NIA Mouse Gene IndexU036692
Consensus CDS ProjectCCDS49740.1
International Mouse Knockout Project StatusItgb7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030863 VEGA Gene Model | MGI Sequence Detail 15941 C57BL/6J ±  kb
transcript OTTMUST00000076379 VEGA | MGI Sequence Detail 2674 Not Applicable 
polypeptide OTTMUSP00000040198 VEGA | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR015437 Integrin beta-7 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009143 integrin beta-7
References (Earliest) J:32336 Yuan Q, et al., Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine. Biochem Biophys Res Commun. 1991 May 15;176(3):1443-9
(Latest) J:209980 Yamada D, et al., beta7 Integrin controls mast cell recruitment, whereas alphaE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. J Immunol. 2014 May 1;192(9):4112-21
All references(100)
Other
accession IDs
MGD-MRK-11495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory