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Ids
Gene Detail
 Symbol
Name
ID
Ids
iduronate 2-sulfatase
MGI:96417
Feature Type protein coding gene
Genetic Map
Chromosome X
36.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:70343069-70365084 bp, - strand
From VEGA annotation of GRCm38

  22016 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: iduronate-2-sulfatase
Gene Tree: Ids

Human
homologs
Human Homolog IDS, iduronate 2-sulfatase
NCBI Gene ID 3423
neXtProt AC  NX_P22304
Human Synonyms  MPS2, SIDS
Human Chr (Location)  Xq28; chrX:149478764-149505354 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IDS
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice with homozygous disruption of this gene display lysosomal accumulation of glycosaminoglycans in multiple tissues, premature death, impaired locomotor activity, joint swelling, and skeletal defects.
 
Human Diseases Modeled Using Mouse Ids (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Ids interacts with 360 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process metabolic process
Component lysosome
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (15)    Images (6)
Theiler Stages: 17, 20, 22, 24
Assay TypeResults
RNA in situ 20
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(2) cDNA(67) Other(1)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000025736 (Evidence)
Ensembl Gene ModelENSMUSG00000035847 (Evidence)
Entrez Gene15931 (Evidence)
UniGene233083
DFCITC1585113, TC1606920, TC1641863, TC1654594, TC1661998, TC1679760
DoTSDT.101364149, DT.101367849, DT.111023974, DT.111023987, DT.40156499, DT.91313801
NIA Mouse Gene IndexU039435
EC3.1.6.13
Consensus CDS ProjectCCDS40996.1, CCDS40997.1
International Mouse Knockout Project StatusIds
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025736 VEGA Gene Model | MGI Sequence Detail 22016 C57BL/6J ±  kb
transcript OTTMUST00000046762 VEGA | MGI Sequence Detail 4972 Not Applicable 
polypeptide OTTMUSP00000021139 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000008894 iduronate 2-sulfatase
References (Earliest) J:11526 Habara-Ohkubo A, et al., Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase. Gene. 1991 Sep 15;105(2):221-7
(Latest) J:188058 Higuchi T, et al., Enzyme replacement therapy (ERT) procedure for mucopolysaccharidosis type II (MPS II) by intraventricular administration (IVA) in murine MPS II. Mol Genet Metab. 2012 Sep;107(1-2):122-8
All references(39)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11187, MGI:2148005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory