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Ids Gene Detail
Summary
  • Symbol
    Ids
  • Name
    iduronate 2-sulfatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96417
    NCBI Gene: 15931
  • Gene Overview
    MyGene.info: IDS
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70343069-70365084 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 36.01 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96417
protein coding gene ChrX:70343069-70385816 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035776
protein coding gene ChrX:65951921-65975849 (-)
A/J MGP_AJ_G0035759
protein coding gene ChrX:66105247-66130044 (-)
AKR/J MGP_AKRJ_G0035680
protein coding gene ChrX:67877924-67900249 (-)
BALB/cJ MGP_BALBcJ_G0035746
protein coding gene ChrX:65288866-65311640 (-)
C3H/HeJ MGP_C3HHeJ_G0035449
protein coding gene ChrX:66399783-66425845 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036276
protein coding gene ChrX:67960062-67981480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033125
protein coding gene ChrX:65004646-65025988 (-)
CAST/EiJ MGP_CASTEiJ_G0034741
protein coding gene ChrX:51867723-51892146 (-)
CBA/J MGP_CBAJ_G0035424
protein coding gene ChrX:69824622-69849878 (-)
DBA/2J MGP_DBA2J_G0035577
protein coding gene ChrX:65660980-65687929 (-)
FVB/NJ MGP_FVBNJ_G0035528
protein coding gene ChrX:65105876-65127609 (-)
LP/J MGP_LPJ_G0035665
protein coding gene ChrX:66726964-66749519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035563
protein coding gene ChrX:72366731-72395059 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036297
protein coding gene ChrX:65791407-65814226 (-)
PWK/PhJ MGP_PWKPhJ_G0034441
protein coding gene ChrX:49933844-49955519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034279
protein coding gene ChrX:52868609-52891159 (-)
WSB/EiJ MGP_WSBEiJ_G0034883
protein coding gene ChrX:65114264-65139502 (-)



Homology
more
  • Human Ortholog
    IDS, iduronate 2-sulfatase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IDS, iduronate 2-sulfatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MPS2, SIDS
  • Links
    NCBI Gene ID: 3423
    neXtProt AC: NX_P22304
    UniProt: P22304

  • Chr Location
    Xq28; chrX:149476990-149505354 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ids mouse models; 1 with human IDS associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with homozygous disruption of this gene display lysosomal accumulation of glycosaminoglycans in multiple tissues, premature death, impaired locomotor activity, joint swelling, and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035847 Ensembl Gene Model | MGI Sequence Detail 22016 C57BL/6J ±  kb
    transcript ENSMUST00000101509 Ensembl | MGI Sequence Detail 4972 Not Applicable  
    polypeptide ENSMUSP00000099046 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 2
      cDNA 68

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-11187, MGI:2148005
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Diseases 4
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:11526 Habara-Ohkubo A, et al., Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase. Gene. 1991 Sep 15;105(2):221-7
    • Latest
      J:265087 Bellesso S, et al., FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII). Hum Mol Genet. 2018 Jul 1;27(13):2262-2275

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory