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Ids
Gene Detail
Symbol

Name
ID
Ids
iduronate 2-sulfatase
MGI:96417
Feature Type
protein coding gene
Genetic Map
Chromosome X
36.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
ChrX:70343069-70365084 bp, - strand
From VEGA annotation of GRCm38

  22016 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IDS
Protein SuperFamily: iduronate-2-sulfatase
Gene Tree: Ids

Human
homologs
IDS, iduronate 2-sulfatase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3423
neXtProt AC: NX_P22304

Human Synonyms: MPS2, SIDS

Human Chr (Location): Xq28; chrX:149478764-149505354 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IDS

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice with homozygous disruption of this gene display lysosomal accumulation of glycosaminoglycans in multiple tissues, premature death, impaired locomotor activity, joint swelling, and skeletal defects.
 
Human Diseases Modeled in Mice Using Ids (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Ids interacts with 359 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process metabolic process
Component lysosome
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (15)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ids ; ZFIN ids    NEW 
Molecular
reagents
All nucleic(70) Genomic(2) cDNA(67) Other(1)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000025736 (Evidence)
Ensembl Gene Model ENSMUSG00000035847 (Evidence)
Entrez Gene 15931 (Evidence)
UniGene 233083
DFCI TC1585113, TC1606920, TC1641863, TC1654594, TC1661998, TC1679760
DoTS DT.101364149, DT.101367849, DT.111023974, DT.111023987, DT.40156499, DT.91313801
NIA Mouse Gene Index U039435
EC 3.1.6.13
Consensus CDS Project CCDS40996.1, CCDS40997.1
International Mouse Phenotyping Consortium Status Ids
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025736 VEGA Gene Model | MGI Sequence Detail 22016 C57BL/6J ±  kb
transcript OTTMUST00000046762 VEGA | MGI Sequence Detail 4972 Not Applicable 
polypeptide OTTMUSP00000021139 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000008894 iduronate 2-sulfatase
References
(Earliest) J:11526 Habara-Ohkubo A, et al., Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase. Gene. 1991 Sep 15;105(2):221-7
(Latest) J:188058 Higuchi T, et al., Enzyme replacement therapy (ERT) procedure for mucopolysaccharidosis type II (MPS II) by intraventricular administration (IVA) in murine MPS II. Mol Genet Metab. 2012 Sep;107(1-2):122-8
All references(38)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11187, MGI:2148005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory