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Ide
Gene Detail
Symbol

Name
ID
Ide
insulin degrading enzyme
MGI:96412
Synonyms
1300012G03Rik, 4833415K22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:37268743-37337852 bp, - strand
From VEGA annotation of GRCm38

  69110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IDE
Protein SuperFamily: insulin-degrading enzyme (IDE)/zinc protease
Gene Tree: Ide

Human
homologs
IDE, insulin-degrading enzyme
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3416
neXtProt AC: NX_P14735

Human Synonyms: INSULYSIN

Human Chr (Location): 10q23-q25; chr10:92451684-92574095 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(61) Targeted(2) Transgenic(1)
 
Mice homozygous for a disruption of this gene display beta amyloid accumulations in the brain, hyperinsulinemia and glucose intolerance.
 
Interactions
Ide interacts with 293 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process beta-amyloid metabolic process, bradykinin catabolic process, ...
Component cell surface, cytoplasm, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (445)    Tissues (168)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 445
cDNA source data(168)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ide ; ZFIN ide    NEW 
Molecular
reagents
All nucleic(172) cDNA(170) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000029864 (Evidence)
Ensembl Gene Model ENSMUSG00000056999 (Evidence)
Entrez Gene 15925 (Evidence)
UniGene 28366
DFCI TC1574845, TC1612095, TC1674779, TC1682511, TC1685925
DoTS DT.102557750, DT.110848178, DT.55114235, DT.91439316, DT.97345293
NIA Mouse Gene Index U149447
EC 3.4.24.56
International Mouse Phenotyping Consortium Status Ide
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029864 VEGA Gene Model | MGI Sequence Detail 69110 C57BL/6J ±  kb
transcript OTTMUST00000074112 VEGA | MGI Sequence Detail 4962 Not Applicable 
polypeptide OTTMUSP00000038463 VEGA | MGI Sequence Detail 987 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(644 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
InterPro IPR007863 Peptidase M16, C-terminal domain
InterPro IPR011237 Peptidase M16 domain
InterPro IPR011765 Peptidase M16, N-terminal
InterPro IPR001431 Peptidase M16, zinc-binding site
Protein Ontology PR:000008886 insulin-degrading enzyme
References
(Earliest) J:11022 Affholter JA, et al., Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35
(Latest) J:213208 Maianti JP, et al., Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 3;511(7507):94-8
All references(56)
Other
accession IDs
MGD-MRK-11179, MGI:1914150, MGI:1921015, MGI:2147459, MGI:2147575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory