About   Help   FAQ
Id1
Gene Detail
Symbol

Name
ID
Id1
inhibitor of DNA binding 1
MGI:96396
Synonyms
bHLHb24, D2Wsu140e, Idb1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:152736251-152737410 bp, + strand
From VEGA annotation of GRCm38

  1160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ID1
Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id1

Human
homologs
ID1, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3397
neXtProt AC: NX_P41134

Human Synonyms: bHLHb24, ID

Human Chr (Location): 20q11; chr20:31605283-31606515 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(36) Targeted(6)
 
Homozygotes for knockout alleles of both Id1 and Id3 exhibit vascular malformations in the forebrain, lack of vascular branching and sprouting in the neuroectoderm, and impaired angiogenesis in transplanted and spontaneous tumors.
 
Interactions
Id1 interacts with 89 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process BMP signaling pathway, collagen metabolic process, ...
Component centrosome, cytoplasm, ...
Function proteasome binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (472)    Tissues (317)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 239
Northern blot 53
Western blot 14
RT-PCR 158
RNase protection 1
cDNA source data(101)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ID1 ZFIN id1    NEW 
Molecular
reagents
All nucleic(113) cDNA(102) Primer pair(9) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015813 (Evidence)
Ensembl Gene Model ENSMUSG00000042745 (Evidence)
Entrez Gene 15901 (Evidence)
UniGene 444
DFCI TC1576104, TC1592216
DoTS DT.101407405, DT.494643
NIA Mouse Gene Index U002653
Consensus CDS Project CCDS16897.1
International Mouse Phenotyping Consortium Status Id1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015813 VEGA Gene Model | MGI Sequence Detail 1160 C57BL/6J ±  kb
transcript OTTMUST00000037598 VEGA | MGI Sequence Detail 1160 Not Applicable 
polypeptide OTTMUSP00000016849 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000039 DNA-binding protein inhibitor ID-1
References
(Earliest) J:18111 Benezra R, et al., The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 1990 Apr 6;61(1):49-59
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(193)
Other
accession IDs
MGD-MRK-11153, MGD-MRK-35816, MGI:107350, MGI:2138900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory