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Id1
Gene Detail
Symbol

Name
ID
Id1
inhibitor of DNA binding 1
MGI:96396
Synonyms
bHLHb24, D2Wsu140e, Idb1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:152736251-152737410 bp, + strand
From VEGA annotation of GRCm38

  1160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id1

Human
homologs
Human Homolog ID1, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
NCBI Gene ID 3397
neXtProt AC  NX_P41134
Human Synonyms  bHLHb24, ID
Human Chr (Location)  20q11; chr20:31605283-31606515 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(36) Targeted(6)
 
Homozygotes for knockout alleles of both Id1 and Id3 exhibit vascular malformations in the forebrain, lack of vascular branching and sprouting in the neuroectoderm, and impaired angiogenesis in transplanted and spontaneous tumors.
 
Interactions
Id1 interacts with 89 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process BMP signaling pathway, collagen metabolic process, ...
Component cytoplasm, Golgi apparatus, ...
Function protein binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (87 records)
Data Summary: Results (461)    Tissues (316)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 239
Northern blot 53
Western blot 3
RT-PCR 158
RNase protection 1
cDNA source data(101)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) cDNA(102) Primer pair(9) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015813 (Evidence)
Ensembl Gene ModelENSMUSG00000042745 (Evidence)
Entrez Gene15901 (Evidence)
UniGene444
DFCITC1576104, TC1592216
DoTSDT.101407405, DT.494643
NIA Mouse Gene IndexU002653
Consensus CDS ProjectCCDS16897.1
International Mouse Knockout Project StatusId1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015813 VEGA Gene Model | MGI Sequence Detail 1160 C57BL/6J ±  kb
transcript OTTMUST00000037598 VEGA | MGI Sequence Detail 1160 Not Applicable 
polypeptide OTTMUSP00000016849 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000039 DNA-binding protein inhibitor ID-1
References
(Earliest) J:18111 Benezra R, et al., The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 1990 Apr 6;61(1):49-59
(Latest) J:205559 Lasorella A, et al., The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014 Feb;14(2):77-91
All references(189)
Other
accession IDs
MGD-MRK-11153, MGD-MRK-35816, MGI:107350, MGI:2138900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory