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Id1 Gene Detail
Summary
  • Symbol
    Id1
  • Name
    inhibitor of DNA binding 1
  • Synonyms
    bHLHb24, D2Wsu140e, Idb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96396
    NCBI Gene: 15901
  • Gene Overview
    MyGene.info: ID1
Location & Maps
more
  • Sequence Map
    Chr2:152736251-152737410 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1160 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ID1, inhibitor of DNA binding 1, HLH protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ID1, inhibitor of DNA binding 1, HLH protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHb24, ID
  • Links
    NCBI Gene ID: 3397
    neXtProt AC: NX_P41134

  • Chr Location
    20q11; chr20:31605283-31606515 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 3 alleles in 6 genetic backgrounds
    37 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    36
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Id1
Homozygotes for knockout alleles of both Id1 and Id3 exhibit vascular malformations in the forebrain, lack of vascular branching and sprouting in the neuroectoderm, and impaired angiogenesis in transplanted and spontaneous tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015813 VEGA Gene Model | MGI Sequence Detail 1160 C57BL/6J ±  kb
transcript OTTMUST00000037598 VEGA | MGI Sequence Detail 1160 Not Applicable  
polypeptide OTTMUSP00000016849 VEGA | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000039 DNA-binding protein inhibitor ID-1
  • InterPro Domains
    IPR026052 DNA-binding protein inhibitor
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 114
    cDNA 103
    Primer pair 9
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11153, MGD-MRK-35816, MGI:107350, MGI:2138900
References
more
  • Summaries
    All 200
    Developmental Gene Expression 93
    Gene Ontology 18
    Phenotypes 49
  • Earliest
    J:18111 Benezra R, et al., The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 1990 Apr 6;61(1):49-59
  • Latest
    J:233010 Man N, et al., Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. Blood. 2016 May 12;127(19):2322-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory