Hspb1
Gene Detail

Symbol Name ID

Hspb1 heat shock protein 1 MGI:96240

Synonyms

Hsp25

Feature Type

protein coding gene

Genetic Map

Chromosome 5

75.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:135887919-135889563 bp, + strand From VEGA annotation of GRCm38   1645 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Sm_HSP_B1
Gene Tree: Hspb1

Human homologs

Human Homolog		HSPB1, heat shock 27kDa protein 1
NCBI Gene ID		3315
neXtProt AC		NX_P04792
Human Synonyms		CMT2F, HMN2B, HS.76067, Hsp25, HSP27, HSP28, SRP27
Human Chr (Location)		7q11.23; chr7:75931875-75933614 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HSPB1

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Mice homozygous for a null allele are viable and fertile with no apparent tissue abnormalities under physiological conditions.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cellular response to vascular endothelial growth factor stimulus, intracellular protein kinase cascade, ...
Component	cell surface, contractile fiber, ...
Function	protein kinase binding, protein kinase C binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (79)    Tissues (63)    Images (13)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 19, 20, 23, 28

Assay Type	Results
Immunohistochemistry	9
Western blot	8
RT-PCR	62

cDNA source data(292)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(301) Genomic(6) cDNA(292) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000024281 (Evidence)
Ensembl Gene Model	ENSMUSG00000004951 (Evidence)
Entrez Gene	15507 (Evidence)
UniGene	13849
DFCI	TC1573470, TC1667115, TC1684482, TC1756221
DoTS	DT.101401203, DT.94158947, DT.94158949, DT.97368839
NIA Mouse Gene Index	U006295, U034732
Consensus CDS Project	CCDS39320.1
International Mouse Knockout Project Status	Hspb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024281	VEGA Gene Model | MGI Sequence Detail	1645	C57BL/6J
transcript	OTTMUST00000059461	VEGA | MGI Sequence Detail	903	Not Applicable
polypeptide	OTTMUSP00000028918	VEGA | MGI Sequence Detail	209	Not Applicable

All sequences(47) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001436	Alpha crystallin/Heat shock protein
InterPro	IPR002068	Alpha crystallin/Hsp20 domain
InterPro	IPR008978	HSP20-like chaperone
Protein Ontology	PR:000008814	heat shock protein beta-1

References

(Earliest) J:40710 Gaestel M, et al., Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem. 1989 Jan 15;179(1):209-13
(Latest) J:169836 Lachke SA, et al., Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6
All references(67)

Other accession IDs

MGD-MRK-10954