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Hspb1 Gene Detail
Summary
  • Symbol
    Hspb1
  • Name
    heat shock protein 1
  • Synonyms
    Hsp25
  • Feature Type
    protein coding gene
  • IDs
    MGI:96240
    NCBI Gene: 15507
  • Gene Overview
    MyGene.info: HSPB1
Location & Maps
more
  • Sequence Map
    Chr5:135887919-135889563 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1645 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.51 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HSPB1, heat shock protein family B (small) member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPB1, heat shock protein family B (small) member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMT2F, HEL-S-102, HMN2B, HS.76067, Hsp25, HSP27, HSP28, SRP27
  • Links
    NCBI Gene ID: 3315
    neXtProt AC: NX_P04792

  • Chr Location
    7q11.23; chr7:76302558-76304297 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human HSPB1 associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Axonal, Type 2F; CMT2F   OMIM: 606595 View 1 model
Neuronopathy, Distal Hereditary Motor, Type IIB; HMN2B   OMIM: 608634 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    3 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    5
  • Targeted
    5
  • Transgenic
    4
  • Incidental Mutations
Mice homozygous for a null allele are viable and fertile with no apparent tissue abnormalities under physiological conditions. Mice homozygous for one knock-out allele exhibit impaired wound healing with delayed wound closing and abnormal inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024281 VEGA Gene Model | MGI Sequence Detail 1645 C57BL/6J ±  kb
transcript OTTMUST00000059461 VEGA | MGI Sequence Detail 903 Not Applicable  
polypeptide OTTMUSP00000028918 VEGA | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008814 heat shock protein beta-1
  • InterPro Domains
    IPR001436 Alpha crystallin/Heat shock protein
    IPR002068 Alpha crystallin/Hsp20 domain
    IPR008978 HSP20-like chaperone
    IPR031107 Small heat shock protein HSP20
Molecular
Reagents
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  • All nucleic 310
    Genomic 6
    cDNA 301
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10954
References
more
  • Summaries
    All 72
    Developmental Gene Expression 20
    Diseases 2
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:40710 Gaestel M, et al., Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem. 1989 Jan 15;179(1):209-13
  • Latest
    J:231333 Choi SH, et al., HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis. Cancer Res. 2016 Mar 1;76(5):1019-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory