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Hspb1
Gene Detail
 Symbol
Name
ID
Hspb1
heat shock protein 1
MGI:96240
Synonyms Hsp25
Feature Type protein coding gene
Genetic Map
Chromosome 5
75.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:135887919-135889563 bp, + strand
From VEGA annotation of GRCm38

  1645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Sm_HSP_B1
Gene Tree: Hspb1

Human
homologs
Human Homolog HSPB1, heat shock 27kDa protein 1
NCBI Gene ID 3315
neXtProt AC  NX_P04792
Human Synonyms  CMT2F, HEL-S-102, HMN2B, HS.76067, Hsp25, HSP27, HSP28, SRP27
Human Chr (Location)  7q11.23; chr7:76302558-76304297 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HSPB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable and fertile with no apparent tissue abnormalities under physiological conditions. Mice homozygous for one knock-out allele exhibit impaired wound healing with delayed wound closing and abnormal inflammatory response.
 
Interactions
Hspb1 interacts with 58 markers (Mir30c-1, Mir30c-2, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to vascular endothelial growth factor stimulus, intracellular signal transduction, ...
Component contractile fiber, cytoplasm, ...
Function identical protein binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (75)    Tissues (62)    Images (13)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 19, 20, 23, 28
Assay TypeResults
Immunohistochemistry 9
Western blot 8
RT-PCR 58
cDNA source data(301)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(310) Genomic(6) cDNA(301) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000024281 (Evidence)
Ensembl Gene ModelENSMUSG00000004951 (Evidence)
Entrez Gene15507 (Evidence)
UniGene13849
DFCITC1573470, TC1667115, TC1684482, TC1756221
DoTSDT.101401203, DT.94158947, DT.94158949, DT.97368839
NIA Mouse Gene IndexU006295, U034732
Consensus CDS ProjectCCDS39320.1
International Mouse Knockout Project StatusHspb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024281 VEGA Gene Model | MGI Sequence Detail 1645 C57BL/6J ±  kb
transcript OTTMUST00000059461 VEGA | MGI Sequence Detail 903 Not Applicable 
polypeptide OTTMUSP00000028918 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000008814 heat shock protein beta-1
References (Earliest) J:40710 Gaestel M, et al., Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem. 1989 Jan 15;179(1):209-13
(Latest) J:209117 Crowe J, et al., Heat shock protein B1-deficient mice display impaired wound healing. PLoS One. 2013;8(10):e77383
All references(71)
Other
accession IDs
MGD-MRK-10954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory