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Hoxa Complex/Cluster/Region Detail
Summary
  • Symbol
    Hoxa
  • Name
    homeobox A cluster
  • Synonyms
    Hox-1
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96169
    NCBI Gene: 111336
  • Cluster Members
    Hoxa1, Hoxa2, Hoxa3 ... (11 members)
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 6, cytoband B3-C
  • Mapping Data
    18 experiments
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    20 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive nervous, cardiovascular, digestive, immune, glandular and renal/urinary systems.
Interactions
less
Sequences &
Gene Models
less
Polymorphisms
less
  • RFLP
Molecular
Reagents
less
  • All nucleic 6
    Genomic 6
Other
Accession IDs
less
MGD-MRK-10814, MGD-MRK-10870
References
more
  • Summaries
    All 55
    Phenotypes 13
  • Earliest
    J:7440 McGinnis W, et al., A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell. 1984 Jun;37(2):403-8
  • Latest
    J:231552 Lebert-Ghali CE, et al., Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells. Blood. 2016 Jan 7;127(1):87-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory