Hoxa Complex/Cluster/Region Detail

Summary

• Symbol
  Hoxa
• Name
  homeobox A cluster
• Synonyms
  Hox-1

• Feature Type
  complex/cluster/region
• IDs
  MGI:96169
  NCBI Gene: 111336
• Cluster Members
  Hoxa1, Hoxa2, Hoxa3 ... (11 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available

• Genetic Map
  Chromosome 6, cytoband B3-C
• Mapping Data
  18 experiments

Strain
Comparison

• RFLP
  3

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 1 genetic background
  20 phenotypes from multigenic genotypes
  19 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  3
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive nervous, cardiovascular, digestive, immune, glandular and renal/urinary systems.

Interactions

• Hoxa interacts with 2 markers (Mir181a-1, Mir181a-2) View All

Sequences &
Gene Models

• NCBI Gene
  111336

Molecular
Reagents

• All nucleic 6

  Genomic 6

Other
Accession IDs

MGD-MRK-10814, MGD-MRK-10870

References

• Summaries
  All 67

  Phenotypes 19
• Earliest
  J:7440 McGinnis W, et al., A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell. 1984 Jun;37(2):403-8
• Latest
  J:277847 Roux M, et al., Multifaceted Hoxa13 function in urogenital development underlies the Hand-Foot-Genital Syndrome. Hum Mol Genet. 2019 May 15;28(10):1671-1681

Hoxa Cluster contains:

More Data for these features

Member	Feature Type	Location
Hoxa1, homeobox A1	protein coding gene	Chr6:52155590-52158317 (-)
Hoxa2, homeobox A2	protein coding gene	Chr6:52162417-52164831 (-)
Hoxa3, homeobox A3	protein coding gene	Chr6:52169059-52213067 (-)
Hoxa4, homeobox A4	protein coding gene	Chr6:52189682-52191703 (-)
Hoxa5, homeobox A5	protein coding gene	Chr6:52201754-52204587 (-)
Hoxa6, homeobox A6	protein coding gene	Chr6:52206288-52208722 (-)
Hoxa7, homeobox A7	protein coding gene	Chr6:52215623-52218573 (-)
Hoxa9, homeobox A9	protein coding gene	Chr6:52223097-52227370 (-)
Hoxa10, homeobox A10	protein coding gene	Chr6:52231197-52240854 (-)
Hoxa11, homeobox A11	protein coding gene	Chr6:52242106-52245810 (-)
Hoxa13, homeobox A13	protein coding gene	Chr6:52258853-52260880 (-)