Hoxa Complex/Cluster/Region Detail

Summary

• Symbol
  Hoxa
• Name
  homeobox A cluster
• Synonyms
  Hox-1

• Feature Type
  complex/cluster/region
• IDs
  MGI:96169
  NCBI Gene: 111336
• Cluster Members
  Hoxa1, Hoxa2, Hoxa3 ... (11 members)
• Regulated by
  Rr543, Rr449, Rr450 ... (6 regulatory regions)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, cytoband B3-C
• Mapping Data
  18 experiments

Strain
Comparison

• RFLP
  3

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 1 genetic background
  20 phenotypes from multigenic genotypes
  19 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  3
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive nervous, cardiovascular, digestive, immune, glandular and renal/urinary systems.

Sequences &
Gene Models

• NCBI Gene
  111336

Molecular
Reagents

• All nucleic 6

  Genomic 6

Other
Accession IDs

MGD-MRK-10814, MGD-MRK-10870

References

• Summaries
  All 68

  Phenotypes 19
• Earliest
  J:7440 McGinnis W, et al., A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell. 1984 Jun;37(2):403-8
• Latest
  J:331393 Mohibi S, et al., Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster. Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166587

Hoxa expression regulated by:

Feature	Feature Type	Location	Reference
Rr543, regulatory region 543	enhancer	Chr6:50650594-51173785	J:344244
Rr449, regulatory region 449	enhancer	Chr6:52130345-52130896	J:24362
Rr450, regulatory region 450	response element	Chr6:52130405-52130423	J:24362
Rr448, regulatory region 448	enhancer	Chr6:52138112-52140568	J:24362
Rr447, regulatory region 447	enhancer	Chr6:52140568-52141812	J:24362
Rr579, regulatory region 579	response element	Chr6, Syntenic	J:208763

Hoxa Cluster contains:

More Data for these features

Member	Feature Type	Location
Hoxa1, homeobox A1	protein coding gene	Chr6:52132573-52135299 (-)
Hoxa2, homeobox A2	protein coding gene	Chr6:52139397-52141811 (-)
Hoxa3, homeobox A3	protein coding gene	Chr6:52146042-52190316 (-)
Hoxa4, homeobox A4	protein coding gene	Chr6:52166662-52168683 (-)
Hoxa5, homeobox A5	protein coding gene	Chr6:52178768-52181437 (-)
Hoxa6, homeobox A6	protein coding gene	Chr6:52183268-52185702 (-)
Hoxa7, homeobox A7	protein coding gene	Chr6:52191471-52198757 (-)
Hoxa9, homeobox A9	protein coding gene	Chr6:52200077-52203169 (-)
Hoxa10, homeobox A10	protein coding gene	Chr6:52208177-52217658 (-)
Hoxa11, homeobox A11	protein coding gene	Chr6:52219086-52222784 (-)
Hoxa13, homeobox A13	protein coding gene	Chr6:52235833-52237865 (-)