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Mst1 Gene Detail
Summary
  • Symbol
    Mst1
  • Name
    macrophage stimulating 1 (hepatocyte growth factor-like)
  • Synonyms
    D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96080
    NCBI Gene: 15235
  • Gene Overview
    MyGene.info: MST1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108080436-108085003 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96080
protein coding gene Chr9:108080405-108085027 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035285
protein coding gene Chr9:110009501-110014068 (+)
A/J MGP_AJ_G0035264
protein coding gene Chr9:105985918-105990485 (+)
AKR/J MGP_AKRJ_G0035196
protein coding gene Chr9:108630739-108635307 (+)
BALB/cJ MGP_BALBcJ_G0035258
protein coding gene Chr9:105682694-105687261 (+)
C3H/HeJ MGP_C3HHeJ_G0034968
protein coding gene Chr9:109029205-109033772 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035778
protein coding gene Chr9:112989426-112993993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032676
protein coding gene Chr9:103420595-103425206 (+)
CAST/EiJ MGP_CASTEiJ_G0034279
protein coding gene Chr9:108985970-108990537 (+)
CBA/J MGP_CBAJ_G0034936
protein coding gene Chr9:116979285-116983852 (+)
DBA/2J MGP_DBA2J_G0035097
protein coding gene Chr9:105441260-105445909 (+)
FVB/NJ MGP_FVBNJ_G0035045
protein coding gene Chr9:104210427-104214994 (+)
LP/J MGP_LPJ_G0035173
protein coding gene Chr9:110197945-110202512 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035084
protein coding gene Chr9:118574389-118578956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035799
protein coding gene Chr9:108913127-108917695 (+)
PWK/PhJ MGP_PWKPhJ_G0033986
protein coding gene Chr9:105762685-105767300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033821
protein coding gene Chr9:108969467-108974043 (+)
WSB/EiJ MGP_WSBEiJ_G0034400
protein coding gene Chr9:108788965-108793532 (+)



Homology
more
  • Human Ortholog
    MST1, macrophage stimulating 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MST1, macrophage stimulating 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D3F15S2, DNF15S2, HGFL, MSP, NF15S2
  • Links
    NCBI Gene ID: 4485
    neXtProt AC: NX_P26927
    UniProt: P26927

  • Chr Location
    3p21.31; chr3:49683947-49689528 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lipid-filled cytoplasmic vacuoles in hepatocytes throughout the liver lobules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032591 Ensembl Gene Model | MGI Sequence Detail 4568 C57BL/6J ±  kb
transcript ENSMUST00000035211 Ensembl | MGI Sequence Detail 2262 Not Applicable  
polypeptide ENSMUSP00000035211 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 20

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10705, MGD-MRK-6224, MGD-MRK-8535, MGD-MRK-8876
References
more
  • Summaries
    All 81
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:11449 Degen SJ, et al., Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry. 1991 Oct 8;30(40):9781-91
  • Latest
    J:272463 Nguyen MN, et al., Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H45-H60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory