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Mst1 Gene Detail
Summary
  • Symbol
    Mst1
  • Name
    macrophage stimulating 1 (hepatocyte growth factor-like)
  • Synonyms
    D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96080
    NCBI Gene: 15235
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107957635-107962202 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96080
 protein coding gene Chr9:107957607-107962226 (+)
129S1/SvImJ ENSMUSG00200043592
 protein coding gene Chr9:105155648-105160215 (+)
A/J ENSMUSG00195041761
 protein coding gene Chr9:104374419-104378986 (+)
AKR/J ENSMUSG00220023441
 protein coding gene Chr9:104761492-104766060 (+)
BALB/cJ ENSMUSG00180031381
 protein coding gene Chr9:104690922-104695490 (+)
C3H/HeJ ENSMUSG00175036884
 protein coding gene Chr9:105033210-105037778 (+)
C57BL/6NJ ENSMUSG00215025983
 protein coding gene Chr9:105010359-105014926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032676
 protein coding gene Chr9:103420595-103425206 (+)
CAST/EiJ ENSTCUG00005030136
 protein coding gene Chr9:104784022-104788589 (+)
CBA/J ENSMUSG00210037865
 protein coding gene Chr9:104882530-104887097 (+)
DBA/2J ENSMUSG00185034685
 protein coding gene Chr9:105042282-105046851 (+)
FVB/NJ ENSMUSG00205031950
 protein coding gene Chr9:105043964-105048532 (+)
JF1/MsJ ENSUMUG00000048471
 protein coding gene Chr9:104871771-104876338 (+)
LP/J ENSMUSG00230046706
 protein coding gene Chr9:105184534-105189101 (+)
NOD/ShiLtJ ENSMUSG00190027600
 protein coding gene Chr9:104681081-104685648 (+)
NZO/HlLtJ ENSMUSG00225022958
 protein coding gene Chr9:105415559-105420128 (+)
PWK/PhJ ENSLUMG00010034719
 protein coding gene Chr9:104828893-104833463 (+)
SPRET/EiJ ENSMSPG00010042346
 protein coding gene Chr9:106656862-106661438 (+)
WSB/EiJ ENSIUOG00005035270
 protein coding gene Chr9:104127556-104132123 (+)



Homology
more
  • Human Ortholog
    MST1, macrophage stimulating 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MST1, macrophage stimulating 1
  • Synonyms
    D3F15S2, DNF15S2, HGFL, MSP, NF15S2
  • Links
    NCBI Gene ID: 4485
    UniProt: P26927

  • Chr Location
    3p21.31; chr3:49683947-49689501 (-)  GRCh38
  • Human Ortholog
    MST1L, macrophage stimulating 1 like (pseudogene)
  • Synonyms
    BRF-1, D1F15S1A, MSPL-7, MSPL7, MST1P, MST1P7, MST1P9, MSTP7, MSTP9
  • Links
    NCBI Gene ID: 11223
    UniProt: Q2TV78

  • Chr Location
    1p36.13; chr1:16757120-16764480 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lipid-filled cytoplasmic vacuoles in hepatocytes throughout the liver lobules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    35
  • cDNA Data
    21
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032591 Ensembl Gene Model | MGI Sequence Detail 4568 C57BL/6J ±  kb
    transcript ENSMUST00000035211 Ensembl | MGI Sequence Detail 2262 Not Applicable  
    polypeptide ENSMUSP00000035211 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 21
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10705, MGD-MRK-6224, MGD-MRK-8535, MGD-MRK-8876
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:11449 Degen SJ, et al., Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry. 1991 Oct 8;30(40):9781-91
    • Latest
      J:372505 Yang H, et al., Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis. Cancer Res. 2025 Oct 1;85(19):3752-3770
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory