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Mst1
Gene Detail
 Symbol
Name
ID
Mst1
macrophage stimulating 1 (hepatocyte growth factor-like)
MGI:96080
Synonyms D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:108080436-108085027 bp, + strand
From VEGA annotation of GRCm38

  4592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: hepatocyte growth factor/macrophage stimulating protein 1
Gene Tree: Mst1

Human
homologs
Human Homolog MST1, macrophage stimulating 1 (hepatocyte growth factor-like)
NCBI Gene ID 4485
neXtProt AC  NX_P26927
Human Synonyms  D3F15S2, DNF15S2, HGFL, MSP, NF15S2
Human Chr (Location)  3p21; chr3:49683947-49689528 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lipid-filled cytoplasmic vacuoles in hepatocytes throughout the liver lobules.
 
Phenotype Images(1)
Interactions
Mst1 interacts with 94 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process embryo implantation, proteolysis
Component extracellular region, extracellular vesicular exosome
Function catalytic activity, serine-type endopeptidase activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (70)    Tissues (30)    Images (24)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 70
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(3) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033726 (Evidence)
Ensembl Gene ModelENSMUSG00000032591 (Evidence)
Entrez Gene15235 (Evidence)
UniGene8369
DFCITC1583338
DoTSDT.55251136
Consensus CDS ProjectCCDS40766.1
International Mouse Knockout Project StatusMst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033726 VEGA Gene Model | MGI Sequence Detail 4592 C57BL/6J ±  kb
transcript OTTMUST00000084949 VEGA | MGI Sequence Detail 2286 Not Applicable 
polypeptide OTTMUSP00000045837 VEGA | MGI Sequence Detail 716 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(13) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003609 Apple-like
InterPro IPR024174 Hepatocyte growth factor/macrophage stimulating protein 1
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR003014 PAN-1 domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010683 hepatocyte growth factor-like protein
References (Earliest) J:11449 Degen SJ, et al., Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry. 1991 Oct 8;30(40):9781-91
(Latest) J:193773 Chae JS, et al., Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1. Free Radic Biol Med. 2012 Oct 17;53(12):2335-2343
All references(42)
Other
accession IDs
MGD-MRK-10705, MGD-MRK-6224, MGD-MRK-8535, MGD-MRK-8876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory