H2-Q1
Gene Detail

Symbol Name ID

H2-Q1 histocompatibility 2, Q region locus 1 MGI:95928

STS

D17Mit47, D17Rua9

Synonyms

H-2Q1, Q1, Q1b, Q1d, Q1k

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr17:35320405-35325099 bp, + strand From VEGA annotation of GRCm38   4695 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128184  Vertebrate Homology Class
1 human; 10 mouse; 16 rat; 1 chimpanzee; 7 rhesus macaque

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q1

Human homologs

Human Homolog		HLA-B, major histocompatibility complex, class I, B
NCBI Gene ID		3106
neXtProt AC		NX_P01889
Human Synonyms		AS, HLAB, SPDA1
Human Chr (Location)		6p21.3; chr6:31321649-31324989 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human HLA-B

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I
Component	integral to membrane, membrane, ...
Function	beta-2-microglobulin binding, peptide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (20)    Images (2)
Theiler Stages: 15, 19, 20, 22, 28

Assay Type	Results
RT-PCR	24

cDNA source data(3)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(23) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037097 (Evidence)
Ensembl Gene Model	ENSMUSG00000079507 (Evidence)
Entrez Gene	15006 (Evidence)
NIA Mouse Gene Index	U378791
Consensus CDS Project	CCDS50086.1
International Mouse Knockout Project Status	H2-Q1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037097	VEGA Gene Model | MGI Sequence Detail	4695	C57BL/6J
transcript	OTTMUST00000095502	VEGA | MGI Sequence Detail	2024	Not Applicable
polypeptide	OTTMUSP00000053287	VEGA | MGI Sequence Detail	368	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR011162	MHC classes I/II-like antigen recognition protein
InterPro	IPR001039	MHC class I, alpha chain, alpha1/alpha2
InterPro	IPR010579	MHC class I, alpha chain, C-terminal
InterPro	IPR011161	MHC class I-like antigen recognition

References

(Earliest) J:6148 Hammerling GJ, et al., Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. J Exp Med. 1979 Jul 1;150(1):108-16
(Latest) J:156818 Oliveira CC, et al., The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects. J Exp Med. 2010 Jan 18;207(1):207-21, S1-2
All references(37)

Other accession IDs

MGD-MRK-10412, MGD-MRK-10524, MGD-MRK-13708, MGD-MRK-13718, MGD-MRK-13736, MGI:3779428