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H2-Q1 Gene Detail
Summary
  • Symbol
    H2-Q1
  • Name
    histocompatibility 2, Q region locus 1
  • Synonyms
    H-2Q1, Q1, Q1b, Q1d, Q1k
  • Feature Type
    protein coding gene
  • IDs
    MGI:95928
    NCBI Gene: 15006
  • Gene Overview
    MyGene.info: HLA-A
Location & Maps
more
  • Sequence Map
    Chr17:35320405-35325099 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4695 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.63 cM
  • Mapping Data
    8 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    57
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
    Orthology source: HomoloGene
  • Synonyms
    Aw-33, Aw-74, HLAA, HLA-A11, HLA-A33, HLA-DQB1, HLA-DRB1
  • Links
    NCBI Gene ID: 3105
    neXtProt AC: NX_P04439, NX_P30443

  • Chr Location
    6p21.3; chr6:29942470-29945884 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HLA-A associations

Human Disease Mouse Models
       Severe Cutaneous Adverse Reaction, Susceptibility to   OMIM: 608579
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
  • All Mutations and Alleles
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving H2-Q1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037097 VEGA Gene Model | MGI Sequence Detail 4695 C57BL/6J ±  kb
transcript OTTMUST00000095502 VEGA | MGI Sequence Detail 2024 Not Applicable  
polypeptide OTTMUSP00000053287 VEGA | MGI Sequence Detail 368 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR027648 MHC class I alpha chain
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR010579 MHC class I, alpha chain, C-terminal
    IPR011161 MHC class I-like antigen recognition-like
Molecular
Reagents
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  • All nucleic 29
    Genomic 23
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10412, MGD-MRK-10524, MGD-MRK-13708, MGD-MRK-13718, MGD-MRK-13736, MGI:3779428
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:6148 Hammerling GJ, et al., Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. J Exp Med. 1979 Jul 1;150(1):108-16
  • Latest
    J:225528 Liu J, et al., Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. Neurochem Res. 2015 Jul;40(7):1487-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory