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H2-Q1
Gene Detail
 Symbol
Name
ID
H2-Q1
histocompatibility 2, Q region locus 1
MGI:95928
STS D17Mit47, D17Rua9
Synonyms H-2Q1, Q1, Q1b, Q1d, Q1k
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:35320405-35325099 bp, + strand
From VEGA annotation of GRCm38

  4695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q1

Human
homologs
Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Genomic Mutations involving H2-Q1 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
H2-Q1 interacts with 135 markers (Mir18b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (20)    Images (2)
Theiler Stages: 15, 19, 20, 22, 28
Assay TypeResults
RT-PCR 24
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(23) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037097 (Evidence)
Ensembl Gene ModelENSMUSG00000079507 (Evidence)
Entrez Gene15006 (Evidence)
NIA Mouse Gene IndexU378791
Consensus CDS ProjectCCDS50086.1
International Mouse Knockout Project StatusH2-Q1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037097 VEGA Gene Model | MGI Sequence Detail 4695 C57BL/6J ±  kb
transcript OTTMUST00000095502 VEGA | MGI Sequence Detail 2024 Not Applicable 
polypeptide OTTMUSP00000053287 VEGA | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(70) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(155 from dbSNP Build 137)    SNPs within 2kb including multiple locations(193)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR010579 MHC class I, alpha chain, C-terminal
InterPro IPR011161 MHC class I-like antigen recognition
References (Earliest) J:6148 Hammerling GJ, et al., Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. J Exp Med. 1979 Jul 1;150(1):108-16
(Latest) J:156818 Oliveira CC, et al., The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects. J Exp Med. 2010 Jan 18;207(1):207-21, S1-2
All references(37)
Other
accession IDs
MGD-MRK-10412, MGD-MRK-10524, MGD-MRK-13708, MGD-MRK-13718, MGD-MRK-13736, MGI:3779428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory