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H2
Complex/Cluster/Region Detail
 Symbol
Name
ID
H2
histocompatibility-2, MHC
MGI:95894
Synonyms H-2, MHC-II
Feature Type complex/cluster/region
Genetic Map
Chromosome 17
cytoband B-C

Mapping data(215)
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
 
The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.
 
Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Expression
Literature Summary: (5 records)
cDNA source data(5)
Molecular
reagents
All nucleic(10) cDNA(8) Other(2)
Other database
links
Entrez Gene111364
Polymorphisms RFLP(12) : SNPs within 2kb(0 from dbSNP Build 137)
References (Earliest) J:301 Snell GD, Preliminary data on crossing-over between H-2, and Fu, Ki and T in the mouse. Heredity. 1952;6:247-54
(Latest) J:210322 Vassallo R, et al., Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes. Clin Immunol. 2014 May-Jun;152(1-2):25-35
All references(592)
Other
accession IDs
MGD-MRK-10366, MGD-MRK-10489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory