H2
Complex/Cluster/Region Detail

Symbol Name ID

H2 histocompatibility-2, MHC MGI:95894

Synonyms

H-2, MHC-II

Feature Type

complex/cluster/region

Genetic Map

Chromosome 17
cytoband B-C

Mapping data(217)

Alleles and phenotypes

All alleles(15) : Targeted(1) Spontaneous(1) Other(13)
 

The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.

 
Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Expression

Literature Summary: (5 records)
cDNA source data(5)

Molecular reagents

All nucleic(10) cDNA(8) Other(2)

Other database links

Entrez Gene

111364

Polymorphisms

RFLP(12) : SNPs(0 from dbSNP Build 128)

References

(Earliest) J:301 Snell GD, Preliminary data on crossing-over between H-2, and Fu, Ki and T in the mouse. Heredity. 1952;6:247-54
(Latest) J:194621 Ophir E, et al., Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells. Blood. 2013 Feb 14;121(7):1220-8
All references(564)

Other accession IDs

MGD-MRK-10366, MGD-MRK-10489