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H2 Complex/Cluster/Region Detail
Summary
  • Symbol
    H2
  • Name
    histocompatibility-2, MHC
  • Synonyms
    H-2, MHC-II
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:95894
    NCBI Gene: 111364
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 17, cytoband B-C
  • Mapping Data
    216 experiments
Strain
Comparison
more
Human Diseases
less
  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 9 alleles in 11 genetic backgrounds
    83 phenotypes from multigenic genotypes
    2 images
    390 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.
Expression
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  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Other 2
Other
Accession IDs
less
MGD-MRK-10366, MGD-MRK-10489
References
more
  • Summaries
    All 710
    Developmental Gene Expression 5
    Diseases 6
    Phenotypes 390
  • Earliest
    J:301 Snell GD, Preliminary data on crossing-over between H-2, and Fu, Ki and T in the mouse. Heredity. 1952;6:247-54
  • Latest
    J:276685 Myers LM, et al., A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPalpha expression. Nat Commun. 2019 Feb 15;10(1):794

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory