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H19 Gene Detail
Summary
  • Symbol
    H19
  • Name
    H19, imprinted maternally expressed transcript
  • Feature Type
    lincRNA gene
  • IDs
    MGI:95891
    NCBI Gene: 14955
Location & Maps
more
  • Sequence Map
    Chr7:142575529-142578143 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2615 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.97 cM
  • Mapping Data
    38 experiments
Homology
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  • Gene Tree
    H19
Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 9 alleles in 11 genetic backgrounds
    21 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Targeted
    10
  • Transgenic
    5
Mice homozygous for a knock-out allele exhibit increased body weight. Mice heterozygous for a maternally inherited knock-out allele exhibit increased placenta and body weight. Mice heterozygous for a different knock-out allele paternally inherited exhibit decreased fetal and postnatal body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014998 VEGA Gene Model | MGI Sequence Detail 2615 C57BL/6J ±  kb
transcript OTTMUST00000035613 VEGA | MGI Sequence Detail 2286 Not Applicable  
polypeptide Q61639 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
Molecular
Reagents
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  • All nucleic 111
    Genomic 47
    cDNA 39
    Primer pair 24
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10486, MGI:2142026
References
more
  • Summaries
    All 281
    Developmental Gene Expression 118
    Diseases 1
    Gene Ontology 6
    Phenotypes 34
  • Earliest
    J:20185 Crouse HV, The controlling element in sex chromosome behavior in Sciara. Genetics. 1960;45:1425-43
  • Latest
    J:236195 Zou T, et al., H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR. Mol Cell Biol. 2016 May;36(9):1332-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory