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Grik4 Gene Detail
Summary
  • Symbol
    Grik4
  • Name
    glutamate receptor, ionotropic, kainate 4
  • Synonyms
    6330551K01Rik, GluRgamma1, KA1, KA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95817
    NCBI Gene: 110637
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:42520412-42945154 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 23.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3250 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95817
protein coding gene Chr9:42518135-42945154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034679
protein coding gene Chr9:40865621-41315486 (-)
A/J MGP_AJ_G0034659
protein coding gene Chr9:39780529-40213477 (-)
AKR/J MGP_AKRJ_G0034585
protein coding gene Chr9:40553902-40992570 (-)
BALB/cJ MGP_BALBcJ_G0034650
protein coding gene Chr9:39510834-39941570 (-)
C3H/HeJ MGP_C3HHeJ_G0034361
protein coding gene Chr9:41047241-41488190 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035173
protein coding gene Chr9:42134244-42579055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032086
protein coding gene Chr9:39397809-39825694 (-)
CAST/EiJ MGP_CASTEiJ_G0033684
protein coding gene Chr9:40854107-41291160 (-)
CBA/J MGP_CBAJ_G0034334
protein coding gene Chr9:43622603-44083324 (-)
DBA/2J MGP_DBA2J_G0034493
protein coding gene Chr9:39699908-40130217 (-)
FVB/NJ MGP_FVBNJ_G0034433
protein coding gene Chr9:38928267-39364652 (-)
LP/J MGP_LPJ_G0034574
protein coding gene Chr9:41149591-41602555 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034477
protein coding gene Chr9:45586456-46039757 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035192
protein coding gene Chr9:40460902-40902473 (-)
PWK/PhJ MGP_PWKPhJ_G0033389
protein coding gene Chr9:39531548-39968989 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033225
protein coding gene Chr9:40727594-41189546 (-)
WSB/EiJ MGP_WSBEiJ_G0033797
protein coding gene Chr9:40502311-40955727 (-)



Homology
more
  • Human Ortholog
    GRIK4, glutamate ionotropic receptor kainate type subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK4, glutamate ionotropic receptor kainate type subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAA1, GluK4, GRIK, KA1
  • Links
    NCBI Gene ID: 2900
    neXtProt AC: NX_Q16099
    UniProt: Q16099

  • Chr Location
    11q23.3; chr11:120511746-120988805 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced GYKI-resistant excitatory postsynaptic current.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110637 NCBI Gene Model | MGI Sequence Detail 424743 C57BL/6J ±  kb
transcript NM_175481 RefSeq | MGI Sequence Detail 3488 C57BL/6  
polypeptide Q8BMF5 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008243 glutamate receptor ionotropic, kainate 4
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 11
    Genomic 2
    cDNA 8
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10255, MGI:2445129
References
more
  • Summaries
    All 73
    Developmental Gene Expression 28
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
  • Latest
    J:254118 De Clercq S, et al., DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory