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Grik4
Gene Detail
 Symbol
Name
ID
Grik4
glutamate receptor, ionotropic, kainate 4
MGI:95817
Synonyms 6330551K01Rik, GluRgamma1, KA1, KA-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
23.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:42518135-42944493 bp, - strand
From VEGA annotation of GRCm38

  426359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik4

Human
homologs
Human Homolog GRIK4, glutamate receptor, ionotropic, kainate 4
NCBI Gene ID 2900
neXtProt AC  NX_Q16099
Human Synonyms  EAA1, GluK4, GRIK, KA1
Human Chr (Location)  11q22.3; chr11:120511756-120988805 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(25) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced GYKI-resistant excitatory postsynaptic current.
 
Phenotype Images(1)
Interactions
Grik4 interacts with 310 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process ionotropic glutamate receptor signaling pathway, ion transmembrane transport, ...
Component axon, cell junction, ...
Function extracellular-glutamate-gated ion channel activity, ion channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (30)    Tissues (26)    Images (3)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 30
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(8) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020650 (Evidence)
Ensembl Gene ModelENSMUSG00000032017 (Evidence)
Entrez Gene110637 (Evidence)
UniGene370291
DFCITC1587220
DoTSDT.97393140
NIA Mouse Gene IndexU030753
Consensus CDS ProjectCCDS23089.1
International Mouse Knockout Project StatusGrik4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020650 VEGA Gene Model | MGI Sequence Detail 426359 C57BL/6J ±  kb
transcript OTTMUST00000048918 VEGA | MGI Sequence Detail 5887 Not Applicable 
polypeptide OTTMUSP00000022554 VEGA | MGI Sequence Detail 956 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(8) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(3310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008243 glutamate receptor ionotropic, kainate 4
References (Earliest) J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
(Latest) J:201377 Lowry ER, et al., The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration. Neuroscience. 2013 Apr 3;235:215-25
All references(63)
Other
accession IDs
MGD-MRK-10255, MGI:2445129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory