Grik4
Gene Detail

Symbol Name ID

Grik4 glutamate receptor, ionotropic, kainate 4 MGI:95817

Synonyms

6330551K01Rik, GluRgamma1, KA1, KA-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

23.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:42518135-42944493 bp, - strand From VEGA annotation of GRCm38   426359 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:81829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik4

Human homologs

Human Homolog		GRIK4, glutamate receptor, ionotropic, kainate 4
NCBI Gene ID		2900
neXtProt AC		NX_Q16099
Human Synonyms		EAA1, GluK4, GRIK, KA1
Human Chr (Location)		11q22.3; chr11:120531028-120856969 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(29) : Targeted(4) Gene trapped(25)
 

Mice homozygous for a knock-out allele exhibit reduced GYKI-resistant excitatory postsynaptic current.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	ionotropic glutamate receptor signaling pathway, ion transport, ...
Component	axon, cell junction, ...
Function	extracellular-glutamate-gated ion channel activity, ion channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (8)    Tissues (4)    Images (2)
Theiler Stages: 22, 23, 26

Assay Type	Results
RNA in situ	8

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) Genomic(1) cDNA(8) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020650 (Evidence)
Ensembl Gene Model	ENSMUSG00000032017 (Evidence)
Entrez Gene	110637 (Evidence)
UniGene	370291
DFCI	TC1587220
DoTS	DT.97393140
NIA Mouse Gene Index	U030753
Consensus CDS Project	CCDS23089.1
International Mouse Knockout Project Status	Grik4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020650	VEGA Gene Model | MGI Sequence Detail	426359	C57BL/6J
transcript	OTTMUST00000048918	VEGA | MGI Sequence Detail	5887	Not Applicable
polypeptide	OTTMUSP00000022554	VEGA | MGI Sequence Detail	956	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(2515 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008243	glutamate receptor, ionotropic kainate 4

References

(Earliest) J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
(Latest) J:193538 Cui S, et al., Developmental expression patterns of kainate receptors in the mouse spinal cord. Neuroreport. 2012 Dec 5;23(17):1012-6
All references(58)

Other accession IDs

MGD-MRK-10255, MGI:2445129