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Grik4 Gene Detail
Summary
  • Symbol
    Grik4
  • Name
    glutamate receptor, ionotropic, kainate 4
  • Synonyms
    6330551K01Rik, GluRgamma1, KA1, KA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95817
    NCBI Gene: 110637
Location & Maps
more
  • Sequence Map
    Chr9:42518135-42944493 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      426359 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GRIK4, glutamate receptor, ionotropic, kainate 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK4, glutamate receptor, ionotropic, kainate 4
    Orthology source: HomoloGene
  • Synonyms
    EAA1, GluK4, GRIK, KA1
  • Links
    NCBI Gene ID: 2900
    neXtProt AC: NX_Q16099

  • Chr Location
    11q22.3; chr11:120511746-120988805 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    25
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced GYKI-resistant excitatory postsynaptic current.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020650 VEGA Gene Model | MGI Sequence Detail 426359 C57BL/6J ±  kb
transcript OTTMUST00000048918 VEGA | MGI Sequence Detail 5887 Not Applicable  
polypeptide OTTMUSP00000022554 VEGA | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3310 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008243 glutamate receptor ionotropic, kainate 4
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 10
    Genomic 1
    cDNA 8
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10255, MGI:2445129
References
more
  • Summaries
    All 61
    Developmental Gene Expression 25
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
  • Latest
    J:217045 Heng YH, et al., NFIX regulates neural progenitor cell differentiation during hippocampal morphogenesis. Cereb Cortex. 2014 Jan;24(1):261-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory