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Glrb
Gene Detail
 Symbol
Name
ID
Glrb
glycine receptor, beta subunit
MGI:95751
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.71 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr3:80843599-80913660 bp, - strand
From VEGA annotation of GRCm38

  70062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20224  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glrb

Human
homologs
Human Homolog GLRB, glycine receptor, beta
NCBI Gene ID 2743
neXtProt AC  NX_P48167
Human Synonyms  HKPX2
Human Chr (Location)  4q31.3; chr4:157076125-157172090 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLRB
Alleles
and
phenotypes
All alleles(2) : Spontaneous(2)
 
Mutations in this gene result in a neurological disorder and premature death.
 
Human Diseases Modeled Using Mouse Glrb (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process acrosome reaction, adult walking behavior, ...
Component cell, cell junction, ...
Function binding, chloride channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (127)    Tissues (114)    Images (14)
Theiler Stages: 10, 18, 22, 23, 25
Assay TypeResults
RNA in situ 119
Western blot 4
RT-PCR 4
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(7) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024419 (Evidence)
Ensembl Gene ModelENSMUSG00000028020 (Evidence)
Entrez Gene14658 (Evidence)
DFCITC1578044, TC1595269, TC1781493
DoTSDT.101245984, DT.111041872, DT.60102546, DT.91557216
NIA Mouse Gene IndexU024183
Consensus CDS ProjectCCDS17424.1
International Mouse Knockout Project StatusGlrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024419 VEGA Gene Model | MGI Sequence Detail 70062 C57BL/6J ±  kb
transcript OTTMUST00000059853 VEGA | MGI Sequence Detail 3029 Not Applicable 
polypeptide OTTMUSP00000029152 VEGA | MGI Sequence Detail 496 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(12) UniProt(5)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(744 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008060 Glycine receptor beta
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000008046 glycine receptor subunit beta
References (Earliest) J:13079 Chai CK, Hereditary spasticity in mice. J Hered. 1961;52:241-243
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(72)
Other
accession IDs
MGD-MRK-10134, MGD-MRK-14513, MGI:2139832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory