Glrb
Gene Detail

Symbol Name ID

Glrb glycine receptor, beta subunit MGI:95751

Feature Type

protein coding gene

Genetic Map

Chromosome 3

35.71 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr3:80843599-80913660 bp, - strand From VEGA annotation of GRCm38   70062 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20224  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glrb

Human homologs

Human Homolog		GLRB, glycine receptor, beta
NCBI Gene ID		2743
neXtProt AC		NX_P48167
Human Synonyms		HKPX2
Human Chr (Location)		4q31.3; chr4:157997277-158093242 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GLRB

Alleles and phenotypes

All alleles(2) : Spontaneous(2)
 

Mutations in this gene result in a neurological disorder and premature death.

 
Human Diseases Modeled Using Mouse Glrb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	acrosome reaction, adult walking behavior, ...
Component	cell junction, chloride channel complex, ...
Function	binding, chloride channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (127)    Tissues (114)    Images (14)
Theiler Stages: 10, 18, 22, 23, 25

Assay Type	Results
RNA in situ	119
Western blot	4
RT-PCR	4

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(7) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024419 (Evidence)
Ensembl Gene Model	ENSMUSG00000028020 (Evidence)
Entrez Gene	14658 (Evidence)
DFCI	TC1578044, TC1595269, TC1781493
DoTS	DT.101245984, DT.111041872, DT.60102546, DT.91557216
NIA Mouse Gene Index	U024183
Consensus CDS Project	CCDS17424.1
International Mouse Knockout Project Status	Glrb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024419	VEGA Gene Model | MGI Sequence Detail	70062	C57BL/6J
transcript	OTTMUST00000059853	VEGA | MGI Sequence Detail	3029	Not Applicable
polypeptide	OTTMUSP00000029152	VEGA | MGI Sequence Detail	496	Not Applicable

All sequences(49) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(581 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008060	Glycine receptor beta
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000008046	glycine receptor subunit beta

References

(Earliest) J:13079 Chai CK, Hereditary spasticity in mice. J Hered. 1961;52:241-243
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(69)

Other accession IDs

MGD-MRK-10134, MGD-MRK-14513, MGI:2139832