Gfpt1
Gene Detail

Symbol Name ID

Gfpt1 glutamine fructose-6-phosphate transaminase 1 MGI:95698

Synonyms

2810423A18Rik, GFA, GFAT, GFAT1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:87042846-87092197 bp, + strand From VEGA annotation of GRCm38   49352 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamine-fructose-6-phosphate aminotransferase (isomerizing)
Gene Tree: Gfpt1

Human homologs

Human Homolog		GFPT1, glutamine--fructose-6-phosphate transaminase 1
NCBI Gene ID		2673
neXtProt AC		NX_Q06210
Human Synonyms		CMSTA1, GFA, GFAT, GFAT1, GFAT 1, GFAT1m, GFPT, GFPT1L, MSLG
Human Chr (Location)		2p13; chr2:69546901-69614386 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GFPT1

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	carbohydrate biosynthetic process, carbohydrate metabolic process, ...
Function	amino acid binding, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (11)
Theiler Stages: 15, 22

Assay Type	Results
RNA in situ	95
RT-PCR	2

cDNA source data(129)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(139) Genomic(3) cDNA(132) Primer pair(3) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000022939 (Evidence)
Ensembl Gene Model	ENSMUSG00000029992 (Evidence)
Entrez Gene	14583 (Evidence)
UniGene	19893
DFCI	TC1581157, TC1610118, TC1616637, TC1687236, TC1690626
DoTS	DT.101392131, DT.486611, DT.531471, DT.91331902, DT.91386787, DT.97368678
NIA Mouse Gene Index	U007127
EC	2.6.1.16
Consensus CDS Project	CCDS39545.1
International Mouse Knockout Project Status	Gfpt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022939	VEGA Gene Model | MGI Sequence Detail	49352	C57BL/6J
transcript	OTTMUST00000055170	VEGA | MGI Sequence Detail	2286	Not Applicable
polypeptide	OTTMUSP00000026385	VEGA | MGI Sequence Detail	697	Not Applicable

All sequences(59) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(214 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000583	Class II glutamine amidotransferase domain
InterPro	IPR005855	Glucosamine-fructose-6-phosphate aminotransferase, isomerising
InterPro	IPR017932	Glutamine amidotransferase type 2 domain
InterPro	IPR001347	Sugar isomerase (SIS)
Protein Ontology	PR:000007946	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

References

(Earliest) J:17432 Sayeski PP, et al., The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence. Gene. 1994 Mar 25;140(2):289-90
(Latest) J:182623 Kebede M, et al., Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2376-81
All references(48)

Other accession IDs

MGD-MRK-10056, MGI:1889798, MGI:1919428, MGI:2141417