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Gfpt1
Gene Detail
Symbol

Name
ID
Gfpt1
glutamine fructose-6-phosphate transaminase 1
MGI:95698
Synonyms
2810423A18Rik, GFA, GFAT, GFAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:87042846-87092197 bp, + strand
From VEGA annotation of GRCm38

  49352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GFPT1
Protein SuperFamily: glutamine-fructose-6-phosphate aminotransferase (isomerizing)
Gene Tree: Gfpt1

Human
homologs
GFPT1, glutamine--fructose-6-phosphate transaminase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2673
neXtProt AC: NX_Q06210

Human Synonyms: CMS12, CMSTA1, GFA, GFAT, GFAT1, GFAT 1, GFAT1m, GFPT, GFPT1L, MSLG

Human Chr (Location): 2p13; chr2:69319769-69387254 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GFPT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Genomic Mutations involving Gfpt1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gfpt1 interacts with 345 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process carbohydrate derivative biosynthetic process, carbohydrate metabolic process, ...
Component extracellular exosome
Function amino acid binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (146)    Tissues (146)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
RT-PCR 2
cDNA source data(144)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gfpt1    NEW 
Molecular
reagents
All nucleic(154) Genomic(3) cDNA(147) Primer pair(3) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000022939 (Evidence)
Ensembl Gene Model ENSMUSG00000029992 (Evidence)
Entrez Gene 14583 (Evidence)
UniGene 19893
DFCI TC1581157, TC1610118, TC1616637, TC1687236, TC1690626
DoTS DT.101392131, DT.486611, DT.531471, DT.91331902, DT.91386787, DT.97368678
NIA Mouse Gene Index U007127
EC 2.6.1.16
Consensus CDS Project CCDS39545.1
International Mouse Phenotyping Consortium Status Gfpt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022939 VEGA Gene Model | MGI Sequence Detail 49352 C57BL/6J ±  kb
transcript OTTMUST00000055170 VEGA | MGI Sequence Detail 2286 Not Applicable 
polypeptide OTTMUSP00000026385 VEGA | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000583 Class II glutamine amidotransferase domain
InterPro IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
InterPro IPR017932 Glutamine amidotransferase type 2 domain
InterPro IPR001347 Sugar isomerase (SIS)
Protein Ontology PR:000007946 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
References
(Earliest) J:17432 Sayeski PP, et al., The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence. Gene. 1994 Mar 25;140(2):289-90
(Latest) J:198047 Li MD, et al., O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 2013 Feb 5;17(2):303-10
All references(52)
Other
accession IDs
MGD-MRK-10056, MGI:1889798, MGI:1919428, MGI:2141417

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory