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Gdf7
Gene Detail
Symbol

Name
ID
Gdf7
growth differentiation factor 7
MGI:95690
Synonyms
BMP12
Feature Type
protein coding gene
Genetic Map
Chromosome 12
3.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:8297934-8301954 bp, - strand
From Ensembl annotation of GRCm38

  4021 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32177  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf7

Human
homologs
Human Homolog GDF7, growth differentiation factor 7
NCBI Gene ID 151449
neXtProt AC  NX_Q7Z4P5
Human Synonyms  BMP12
Human Chr (Location)  2p24.1; chr2:20666664-20671490 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele lack D1A neurons in the dorsal spinal cord; some develop severe hydrocephaly with dilated ventricles and late-onset brain defects. Mice homozygous for another null allele show premature death, hydrocephaly, aberrant seminal vesicle development and male sterility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process activin receptor signaling pathway, axon guidance, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (7)    Tissues (7)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 2
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(2) Primer pair(2) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000037660 (Evidence)
Entrez Gene238057 (Evidence)
UniGene271308
DFCITC1595992
DoTSDT.101721295
NIA Mouse Gene IndexU033789
International Mouse Knockout Project StatusGdf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037660 Ensembl Gene Model | MGI Sequence Detail 4021 C57BL/6J ±  kb
transcript ENSMUST00000037313 Ensembl | MGI Sequence Detail 1407 Not Applicable 
polypeptide ENSMUSP00000038301 Ensembl | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000282 growth/differentiation factor 7
References
(Earliest) J:17582 Storm EE, et al., Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments]. Nature. 1994 Apr 14;368(6472):639-43
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(61)
Other
accession IDs
MGD-MRK-10043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory