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Gdf7 Gene Detail
Summary
  • Symbol
    Gdf7
  • Name
    growth differentiation factor 7
  • Synonyms
    BMP12
  • Feature Type
    protein coding gene
  • IDs
    MGI:95690
    NCBI Gene: 238057
  • Gene Overview
    MyGene.info: GDF7
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 12, 3.85 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GDF7, growth differentiation factor 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GDF7, growth differentiation factor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMP12
  • Links
    NCBI Gene ID: 151449
    neXtProt AC: NX_Q7Z4P5
    UniProt: Q7Z4P5

  • Chr Location
    2p24.1; chr2:20666664-20671490 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack D1A neurons in the dorsal spinal cord; some develop severe hydrocephaly with dilated ventricles and late-onset brain defects. Mice homozygous for another null allele show premature death, hydrocephaly, aberrant seminal vesicle development and male sterility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238057 NCBI Gene Model | MGI Sequence Detail 4037 C57BL/6J ±  kb
    transcript NM_001312876 RefSeq | MGI Sequence Detail 1423 C57BL/6  
    polypeptide P43029 UniProt | EBI | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      63 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 8
      Genomic 1
      cDNA 4
      Primer pair 2
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
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    MGD-MRK-10043
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 30
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:17582 Storm EE, et al., Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments]. Nature. 1994 Apr 14;368(6472):639-43
    • Latest
      J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory