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Galt
Gene Detail
Symbol

Name
ID
Galt
galactose-1-phosphate uridyl transferase
MGI:95638
Feature Type
protein coding gene
Genetic Map
Chromosome 4
22.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr4:41755228-41758695 bp, + strand
From VEGA annotation of GRCm38

  3468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GALT
Protein SuperFamily: galactose-1-phosphate uridylyltransferase
Gene Tree: Galt

Human
homologs
GALT, galactose-1-phosphate uridylyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2592
neXtProt AC: NX_P07902

Human Chr (Location): 9p13; chr9:34646589-34650598 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GALT

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit abnormal galactose metabolism, but lack symptoms of acute toxicity seen in humans with galactosemia.
 
Interactions
Galt interacts with 67 markers (Mir18, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process carbohydrate metabolic process, galactose catabolic process via UDP-galactose, ...
Component Golgi apparatus
Function catalytic activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (112)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase galt    NEW 
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(9) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006678 (Evidence)
Ensembl Gene Model ENSMUSG00000036073 (Evidence)
Entrez Gene 14430 (Evidence)
DFCI TC1579669, TC1596376, TC1630028, TC1710141
DoTS DT.101238239, DT.101301916, DT.101342136, DT.91446979, DT.94336811, DT.97380344
NIA Mouse Gene Index U004218
EC 2.7.7.12
Consensus CDS Project CCDS38720.1
International Mouse Phenotyping Consortium Status Galt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006678 VEGA Gene Model | MGI Sequence Detail 3468 C57BL/6J ±  kb
transcript OTTMUST00000015297 VEGA | MGI Sequence Detail 1595 Not Applicable 
polypeptide OTTMUSP00000007068 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001937 Galactose-1-phosphate uridyl transferase, class I
InterPro IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site
InterPro IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal
InterPro IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal
InterPro IPR011146 HIT-like domain
Protein Ontology PR:000007834 galactose-1-phosphate uridylyltransferase
References
(Earliest) J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGD-MRK-9964, MGI:2147374

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory