Galt
Gene Detail

Symbol Name ID

Galt galactose-1-phosphate uridyl transferase MGI:95638

Feature Type

protein coding gene

Genetic Map

Chromosome 4

22.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr4:41755228-41758695 bp, + strand From VEGA annotation of GRCm38   3468 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: galactose-1-phosphate uridylyltransferase
Gene Tree: Galt

Human homologs

Human Homolog		GALT, galactose-1-phosphate uridylyltransferase
NCBI Gene ID		2592
neXtProt AC		NX_P07902
Human Chr (Location)		9p13; chr9:34646586-34650595 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GALT

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygotes for a targeted null mutation exhibit abnormal galactose metabolism, but lack symptoms of acute toxicity seen in humans with galactosemia.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	carbohydrate metabolic process, galactose metabolic process, ...
Component	Golgi apparatus
Function	catalytic activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (112)    Images (4)
Theiler Stages: 11, 13, 22, 23

Assay Type	Results
RNA in situ	121

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(62) Genomic(3) cDNA(58) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006678 (Evidence)
Ensembl Gene Model	ENSMUSG00000036073 (Evidence)
Entrez Gene	14430 (Evidence)
UniGene	439669
DFCI	TC1579669, TC1596376, TC1630028
DoTS	DT.101301916, DT.91446979, DT.94336811, DT.97380344
NIA Mouse Gene Index	U004218
EC	2.7.7.12
Consensus CDS Project	CCDS38720.1
International Mouse Knockout Project Status	Galt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006678	VEGA Gene Model | MGI Sequence Detail	3468	C57BL/6J
transcript	OTTMUST00000015297	VEGA | MGI Sequence Detail	1595	Not Applicable
polypeptide	OTTMUSP00000007068	VEGA | MGI Sequence Detail	360	Not Applicable

All sequences(51) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001937	Galactose-1-phosphate uridyl transferase, class I
InterPro	IPR019779	Galactose-1-phosphate uridyl transferase, class I His-active site
InterPro	IPR005850	Galactose-1-phosphate uridyl transferase, C-terminal
InterPro	IPR005849	Galactose-1-phosphate uridyl transferase, N-terminal
InterPro	IPR011146	HIT-like domain
Protein Ontology	PR:000007834	galactose-1-phosphate uridylyltransferase

References

(Earliest) J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(46)

Other accession IDs

MGD-MRK-9964, MGI:2147374