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Fgf7
Gene Detail
Symbol

Name
ID
Fgf7
fibroblast growth factor 7
MGI:95521
Synonyms
Keratinocyte growth factor, Kgf
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.76 cM, cytoband F-G
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:126034658-126091185 bp, + strand
From VEGA annotation of GRCm38

  56528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7316  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGF7
Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf7

Human
homologs
FGF7, fibroblast growth factor 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2252
neXtProt AC: NX_P21781

Human Synonyms: HBGF-7, KGF

Human Chr (Location): 15q21.2; chr15:49423178-49487326 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal coat appearance, kidney dysplasia, spleen hypoplasia, abnormal synaptic vesicle clustering and miniature inhibitory postsynaptic currents, increased susceptibility to drug-induced seizures, and impaired thymic recovery after injury.
 
Interactions
Fgf7 interacts with 237 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (74 records)
Data Summary: Results (558)    Tissues (364)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 504
Northern blot 5
RT-PCR 49
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGF7 ; Xenbase fgf7    NEW 
Molecular
reagents
All nucleic(31) Genomic(2) cDNA(16) Primer pair(12) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015341 (Evidence)
Ensembl Gene Model ENSMUSG00000027208 (Evidence)
Entrez Gene 14178 (Evidence)
DFCI TC1583198, TC1590084, TC1592251, TC1619561
DoTS DT.87040266, DT.91304697, DT.94223997
NIA Mouse Gene Index U002415, U143662
Consensus CDS Project CCDS16681.1
International Mouse Phenotyping Consortium Status Fgf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015341 VEGA Gene Model | MGI Sequence Detail 56528 C57BL/6J ±  kb
transcript OTTMUST00000036358 VEGA | MGI Sequence Detail 2672 Not Applicable 
polypeptide OTTMUSP00000016341 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007498 fibroblast growth factor 7
References
(Earliest) J:29167 Rubin JS, et al., Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989 Feb;86(3):802-6
(Latest) J:219210 Nikolaou KC, et al., Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015 Feb 12;34(4):430-47
All references(146)
Other
accession IDs
MGD-MRK-9772

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory