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Fgf7
Gene Detail
 Symbol
Name
ID
Fgf7
fibroblast growth factor 7
MGI:95521
Synonyms Keratinocyte growth factor, Kgf
Feature Type protein coding gene
Genetic Map
Chromosome 2
61.76 cM, cytoband F-G
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:126034658-126091185 bp, + strand
From VEGA annotation of GRCm38

  56528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7316  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf7

Human
homologs
Human Homolog FGF7, fibroblast growth factor 7
NCBI Gene ID 2252
neXtProt AC  NX_P21781
Human Synonyms  HBGF-7, KGF
Human Chr (Location)  15q21.2; chr15:49423178-49487326 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal coat appearance, kidney dysplasia, spleen hypoplasia, abnormal synaptic vesicle clustering and miniature inhibitory postsynaptic currents, increased susceptibility to drug-induced seizures, and impaired thymic recovery after injury.
 
Interactions
Fgf7 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process actin cytoskeleton reorganization, branching involved in salivary gland morphogenesis, ...
Component cell, extracellular region, ...
Function chemoattractant activity, fibroblast growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (397)    Tissues (265)    Images (62)
Theiler Stages: 3, 4, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 343
Northern blot 5
RT-PCR 49
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(14) Primer pair(12) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015341 (Evidence)
Ensembl Gene ModelENSMUSG00000027208 (Evidence)
Entrez Gene14178 (Evidence)
DFCITC1583198, TC1590084, TC1592251, TC1619561
DoTSDT.87040266, DT.94223997
NIA Mouse Gene IndexU002415
Consensus CDS ProjectCCDS16681.1
International Mouse Knockout Project StatusFgf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015341 VEGA Gene Model | MGI Sequence Detail 56528 C57BL/6J ±  kb
transcript OTTMUST00000036358 VEGA | MGI Sequence Detail 2672 Not Applicable 
polypeptide OTTMUSP00000016341 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007498 fibroblast growth factor 7
References (Earliest) J:29167 Rubin JS, et al., Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989 Feb;86(3):802-6
(Latest) J:204470 Inagawa M, et al., Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
All references(142)
Other
accession IDs
MGD-MRK-9772

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory