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Ptk2
Gene Detail
Symbol

Name
ID
Ptk2
PTK2 protein tyrosine kinase 2
MGI:95481
Synonyms
Fadk, FAK, FRNK
Feature Type
protein coding gene
Genetic Map
Chromosome 15
33.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr15:73205105-73423191 bp, - strand
From Ensembl annotation of GRCm38

  218087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: focal adhesion kinase 1/2
Gene Tree: Ptk2

Human
homologs
Human Homolog PTK2, protein tyrosine kinase 2
NCBI Gene ID 5747
neXtProt AC  NX_Q05397
Human Synonyms  FADK, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71
Human Chr (Location)  8q24.3; chr8:140658382-141001313 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(44) Radiation induced(1) Targeted(16)
Genomic Mutations involving Ptk2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.
 
Phenotype Images(4)
Interactions
Ptk2 interacts with 224 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (115 annotations)
Process angiogenesis, blood vessel development, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (404)    Tissues (232)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 184
Northern blot 15
Western blot 34
RT-PCR 165
cDNA source data(162)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(179) Genomic(1) cDNA(164) Primer pair(13) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022607 (Evidence)
Entrez Gene14083 (Evidence)
UniGene254494
DFCITC1574936, TC1588370, TC1589205, TC1589855, TC1600831, TC1725592
DoTSDT.101398350, DT.101398354, DT.110838878, DT.491966, DT.110839021, DT.110839026, DT.55274363, DT.94277536, DT.97382310
NIA Mouse Gene IndexU036273
EC2.7.10.2
PDB1KKY, 1K40, 1KL0
Consensus CDS ProjectCCDS37099.1, CCDS49631.1
International Mouse Knockout Project StatusPtk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022607 Ensembl Gene Model | MGI Sequence Detail 218087 C57BL/6J ±  kb
transcript ENSMUST00000110036 Ensembl | MGI Sequence Detail 4414 Not Applicable 
polypeptide ENSMUSP00000105663 Ensembl | MGI Sequence Detail 1052 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(47) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(612 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR005189 Focal adhesion kinase, targeting (FAT) domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003031 focal adhesion kinase 1
References
(Earliest) J:638 Russell JC, et al., Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat. Diabetes Res. 1990 Oct;15(2):53-62
(Latest) J:208263 Jean C, et al., Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 2014 Jan 20;204(2):247-63
All references(251)
Other
accession IDs
MGD-MRK-9708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory