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Ptk2 Gene Detail
Summary
  • Symbol
    Ptk2
  • Name
    PTK2 protein tyrosine kinase 2
  • Synonyms
    Fadk, FAK, FRNK
  • Feature Type
    protein coding gene
  • IDs
    MGI:95481
    NCBI Gene: 14083
  • Gene Overview
    MyGene.info: PTK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:73205102-73423275 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      218174 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 33.94 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FADK, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71
  • Links
    NCBI Gene ID: 5747
    neXtProt AC: NX_Q05397
    UniProt: Q05397

  • Chr Location
    8q24.3; chr8:140658382-141001313 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 13 alleles in 17 genetic backgrounds
    7 phenotypes from multigenic genotypes
    6 images
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14083 NCBI Gene Model | MGI Sequence Detail 218174 C57BL/6J ±  kb
    transcript NM_001358045 RefSeq | MGI Sequence Detail 4735 C57BL/6  
    polypeptide P34152 UniProt | EBI | MGI Sequence Detail 1090 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      608 from dbSNP Build 142
    • PCR
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 180
      Genomic 1
      cDNA 165
      Primer pair 13
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
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    MGD-MRK-9708
    References
    more
    • Summaries
      All 344
      Developmental Gene Expression 65
      Diseases 1
      Gene Ontology 34
      Phenotypes 140
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264095 Heim JB, et al., FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis. PLoS One. 2018;13(7):e0200558

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory