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Ptk2 Gene Detail
Summary
  • Symbol
    Ptk2
  • Name
    PTK2 protein tyrosine kinase 2
  • Synonyms
    Fadk, FAK, FRNK
  • Feature Type
    protein coding gene
  • IDs
    MGI:95481
    NCBI Gene: 14083
  • Gene Overview
    MyGene.info: PTK2
Location & Maps
more
  • Sequence Map
    Chr15:73205105-73423191 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      218087 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 33.94 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTK2, protein tyrosine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FADK, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71
  • Links
    NCBI Gene ID: 5747
    neXtProt AC: NX_Q05397

  • Chr Location
    8q24.3; chr8:140658382-141001313 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 13 alleles in 17 genetic backgrounds
    7 phenotypes from multigenic genotypes
    4 images
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    72
  • Chemically induced (other)
    3
  • Gene trapped
    44
  • Radiation induced
    2
  • Targeted
    23
  • Genomic Mutations
    5 involving Ptk2
  • Incidental Mutations
Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022607 Ensembl Gene Model | MGI Sequence Detail 218087 C57BL/6J ±  kb
transcript ENSMUST00000110036 Ensembl | MGI Sequence Detail 4414 Not Applicable  
polypeptide ENSMUSP00000105663 Ensembl | MGI Sequence Detail 1052 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    608 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 179
    Genomic 1
    cDNA 164
    Primer pair 13
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-9708
References
more
  • Summaries
    All 270
    Developmental Gene Expression 59
    Diseases 1
    Gene Ontology 33
    Phenotypes 123
  • Earliest
    J:638 Russell JC, et al., Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat. Diabetes Res. 1990 Oct;15(2):53-62
  • Latest
    J:228638 Greenman R, et al., Non-cell autonomous and non-catalytic activities of ATX in the developing brain. Front Neurosci. 2015;9:53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory