Ptk2
Gene Detail

Symbol Name ID

Ptk2 PTK2 protein tyrosine kinase 2 MGI:95481

Synonyms

Fadk, fak, FAK, FRNK

Feature Type

protein coding gene

Genetic Map

Chromosome 15

33.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr15:73205105-73423191 bp, - strand From NCBI annotation of GRCm38   218087 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: focal adhesion kinase 1/2
Gene Tree: Ptk2

Human homologs

Human Homolog		PTK2, protein tyrosine kinase 2
NCBI Gene ID		5747
neXtProt AC		NX_Q05397
Human Synonyms		FADK, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71
Human Chr (Location)		8q24.3; chr8:141668481-142011412 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(59) : Targeted(15) Gene trapped(44)
 

Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (98 annotations)

Process	angiogenesis, blood vessel development, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (251)    Tissues (90)    Images (54)
Theiler Stages: 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	46
Northern blot	15
Western blot	25
RT-PCR	161

cDNA source data(165)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(181) Genomic(1) cDNA(167) Primer pair(12) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000022607 (Evidence)
Entrez Gene	14083 (Evidence)
UniGene	254494
DFCI	TC1574936, TC1588370, TC1589205, TC1589855, TC1600831, TC1725592
DoTS	DT.101398350, DT.101398354, DT.110838878, DT.110839021, DT.110839026, DT.491966, DT.55274363, DT.94277536, DT.97382310
NIA Mouse Gene Index	U036273
EC	2.7.10.2
PDB	1KKY, 1K40, 1KL0
Consensus CDS Project	CCDS37099.1, CCDS49631.1
International Mouse Knockout Project Status	Ptk2

Sequences

Length	Strain/Species
genomic	14083	NCBI Gene Model | MGI Sequence Detail	218087	C57BL/6J
transcript	NM_007982	RefSeq | MGI Sequence Detail	4414	Not Specified
polypeptide	P34152	UniProt | EBI | MGI Sequence Detail	1090	Not Applicable

All sequences(51) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(493 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR014352	FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro	IPR019748	FERM central domain
InterPro	IPR000299	FERM domain
InterPro	IPR005189	Focal adhesion kinase, targeting (FAT) domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000003031	focal adhesion kinase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:638 Russell JC, et al., Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat. Diabetes Res. 1990 Oct;15(2):53-62
(Latest) J:195230 Akhtar N, et al., An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol. 2013 Jan;15(1):17-27
All references(226)

Other accession IDs

MGD-MRK-9708