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En2 Gene Detail
Summary
  • Symbol
    En2
  • Name
    engrailed 2
  • Synonyms
    En-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95390
    NCBI Gene: 13799
  • Gene Overview
    MyGene.info: EN2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:28165694-28172166 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 13.94 cM
  • Mapping Data
    45 experiments
Homology
more
  • Human Ortholog
    EN2, engrailed homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EN2, engrailed homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2020
    neXtProt AC: NX_P19622
    UniProt: P19622

  • Chr Location
    7q36.3; chr7:155458129-155464831 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with En2 mouse models; 1 with human EN2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 9 genetic backgrounds
    45 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037277 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
    transcript OTTMUST00000096171 VEGA | MGI Sequence Detail 3539 Not Applicable  
    polypeptide OTTMUSP00000053701 VEGA | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      42 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 6
      cDNA 22
      Primer pair 5
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9498, MGD-MRK-9500, MGI:2141264
    References
    more
    • Summaries
      All 291
      Developmental Gene Expression 150
      Diseases 4
      Gene Ontology 11
      Phenotypes 74
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:264792 Boschian C, et al., Impaired Neuronal Differentiation of Neural Stem Cells Lacking the Engrailed-2 Gene. Neuroscience. 2018 Aug 21;386:137-149

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory