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En2
Gene Detail
Symbol

Name
ID
En2
engrailed 2
MGI:95390
Synonyms
En-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
13.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(45)
Sequence Map
Chr5:28165694-28172166 bp, + strand
From VEGA annotation of GRCm38

  6473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: homeobox protein, EN-1/EN-2 type
Gene Tree: En2

Human
homologs
Human Homolog EN2, engrailed homeobox 2
NCBI Gene ID 2020
neXtProt AC  NX_P19622
Human Chr (Location)  7q36; chr7:155458129-155464831 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(168) : Gene trapped(154) Radiation induced(3) Targeted(11)
Genomic Mutations involving En2 (3)
Incidental mutations (data from Mutagenetix , APF )
 
This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects.
 
Human Diseases Modeled Using Mouse En2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
En2 interacts with 361 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process hindbrain development, midbrain development, ...
Component membrane, nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (133 records)
Data Summary: Results (637)    Tissues (224)    Images (123)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 33
RNA in situ 431
Northern blot 31
RT-PCR 139
RNase protection 3
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(6) cDNA(20) Primer pair(4) Other(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037277 (Evidence)
Ensembl Gene ModelENSMUSG00000039095 (Evidence)
Entrez Gene13799 (Evidence)
UniGene4298
DFCITC1587739
DoTSDT.87072058, DT.91281408
NIA Mouse Gene IndexU005384
Consensus CDS ProjectCCDS19143.1
International Mouse Knockout Project StatusEn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037277 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
transcript OTTMUST00000096171 VEGA | MGI Sequence Detail 3539 Not Applicable 
polypeptide OTTMUSP00000053701 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(15) : PCR(1) RFLP(14) SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR019549 Homeobox engrailed, C-terminal
InterPro IPR019737 Homeobox engrailed-type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR000747 Homeodomain engrailed
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007071 homeobox protein engrailed-2
References
(Earliest) J:9012 Joyner AL, et al., En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis [published erratum appears in Genes Dev 1987 Jul;1(5):521]. Genes Dev. 1987 Mar;1(1):29-38
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(240)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9498, MGD-MRK-9500, MGI:2141264

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory