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En2 Gene Detail
Summary
  • Symbol
    En2
  • Name
    engrailed 2
  • Synonyms
    En-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95390
    NCBI Gene: 13799
  • Gene Overview
    MyGene.info: EN2
Location & Maps
more
  • Sequence Map
    Chr5:28165694-28172166 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 13.94 cM
  • Mapping Data
    45 experiments
Homology
more
  • Human Ortholog
    EN2, engrailed homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EN2, engrailed homeobox 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2020
    neXtProt AC: NX_P19622

  • Chr Location
    7q36; chr7:155458129-155464831 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with En2 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 9 genetic backgrounds
    45 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    173
  • Chemically induced (other)
    2
  • Gene trapped
    154
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    11
  • Genomic Mutations
    8 involving En2
  • Incidental Mutations
This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037277 VEGA Gene Model | MGI Sequence Detail 6473 C57BL/6J ±  kb
transcript OTTMUST00000096171 VEGA | MGI Sequence Detail 3539 Not Applicable  
polypeptide OTTMUSP00000053701 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 6
    cDNA 20
    Primer pair 4
    Other 11

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9498, MGD-MRK-9500, MGI:2141264
References
more
  • Summaries
    All 252
    Developmental Gene Expression 144
    Diseases 5
    Gene Ontology 11
    Phenotypes 69
  • Earliest
    J:9012 Joyner AL, et al., En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis [published erratum appears in Genes Dev 1987 Jul;1(5):521]. Genes Dev. 1987 Mar;1(1):29-38
  • Latest
    J:230833 Mardaryev AN, et al., Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4;212(1):77-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory