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En2
Gene Detail
 Symbol
Name
ID
En2
engrailed 2
MGI:95390
Synonyms En-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
13.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(45)
Sequence Map
Chr5:28165696-28173612 bp, + strand
From VEGA annotation of GRCm38

  7917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55579  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: homeobox protein, EN-1/EN-2 type
Gene Tree: En2

Human
homologs
Human Homolog EN2, engrailed homeobox 2
NCBI Gene ID 2020
neXtProt AC  NX_P19622
Human Chr (Location)  7q36; chr7:155458129-155464831 (+)  GRCh38
Alleles
and
phenotypes
All alleles(165) : Targeted(11) Gene trapped(154)
 
This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects.
 
Human Diseases Modeled Using Mouse En2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hindbrain development, midbrain development, ...
Component membrane, nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (132 records)
Data Summary: Results (637)    Tissues (210)    Images (123)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 33
RNA in situ 431
Northern blot 31
RT-PCR 139
RNase protection 3
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) Genomic(6) cDNA(20) Primer pair(4) Other(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037277 (Evidence)
Ensembl Gene ModelENSMUSG00000039095 (Evidence)
Entrez Gene13799 (Evidence)
UniGene4298
DFCITC1587739
DoTSDT.87072058, DT.91281408
NIA Mouse Gene IndexU005384
Consensus CDS ProjectCCDS19143.1
International Mouse Knockout Project StatusEn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037277 VEGA Gene Model | MGI Sequence Detail 7917 C57BL/6J ±  kb
transcript OTTMUST00000096171 VEGA | MGI Sequence Detail 4983 Not Applicable 
polypeptide OTTMUSP00000053701 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(15) : PCR(1) RFLP(14) SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR019549 Homeobox engrailed, C-terminal
InterPro IPR019737 Homeobox engrailed-type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR000747 Homeodomain engrailed
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007071 homeobox protein engrailed-2
References (Earliest) J:9012 Joyner AL, et al., En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis [published erratum appears in Genes Dev 1987 Jul;1(5):521]. Genes Dev. 1987 Mar;1(1):29-38
(Latest) J:203582 Sgado P, et al., Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders. Exp Neurol. 2013 Sep;247:496-505
All references(239)
Other
accession IDs
MGD-MRK-9498, MGD-MRK-9500, MGI:2141264

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory