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Epha2 Gene Detail
Summary
  • Symbol
    Epha2
  • Name
    Eph receptor A2
  • Synonyms
    Eck, Myk2, Sek2, Sek-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95278
    NCBI Gene: 13836
  • Gene Overview
    MyGene.info: EPHA2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141301240-141329384 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.67 cM, cytoband D-E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95278
protein coding gene Chr4:141301221-141329384 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029043
protein coding gene Chr4:144348882-144376938 (+)
A/J MGP_AJ_G0029002
protein coding gene Chr4:138067526-138095628 (+)
AKR/J MGP_AKRJ_G0028954
protein coding gene Chr4:142051537-142081829 (+)
BALB/cJ MGP_BALBcJ_G0029026
protein coding gene Chr4:138760126-138788312 (+)
C3H/HeJ MGP_C3HHeJ_G0028740
protein coding gene Chr4:142427269-142456757 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029467
protein coding gene Chr4:149382805-149410824 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026738
protein coding gene Chr4:130980717-131008877 (+)
CAST/EiJ MGP_CASTEiJ_G0028172
protein coding gene Chr4:140691600-140723999 (+)
CBA/J MGP_CBAJ_G0028704
protein coding gene Chr4:153710920-153742865 (+)
DBA/2J MGP_DBA2J_G0028854
protein coding gene Chr4:138470445-138499358 (+)
FVB/NJ MGP_FVBNJ_G0028821
protein coding gene Chr4:137574029-137603912 (+)
LP/J MGP_LPJ_G0028953
protein coding gene Chr4:144366970-144396454 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028847
protein coding gene Chr4:157550755-157582148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029505
protein coding gene Chr4:142581796-142611774 (+)
PWK/PhJ MGP_PWKPhJ_G0027893
protein coding gene Chr4:135357410-135385924 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027718
protein coding gene Chr4:138389662-138418352 (+)
WSB/EiJ MGP_WSBEiJ_G0028250
protein coding gene Chr4:142864480-142892726 (+)



Homology
more
  • Human Ortholog
    EPHA2, EPH receptor A2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHA2, EPH receptor A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARCC2, CTPA, CTPP1, CTRCT6, ECK
  • Links
    NCBI Gene ID: 1969
    neXtProt AC: NX_P29317
    UniProt: P29317

  • Chr Location
    1p36.13; chr1:16124337-16156104 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Epha2 mouse models; 1 with human EPHA2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006445 Ensembl Gene Model | MGI Sequence Detail 28145 C57BL/6J ±  kb
    transcript ENSMUST00000006614 Ensembl | MGI Sequence Detail 3913 Not Applicable  
    polypeptide ENSMUSP00000006614 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007122 ephrin type-A receptor 2
    • PDB
    • EC
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR034263 Ephrin type-A receptor 2, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 66
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9293, MGI:2140587
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 48
      Diseases 1
      Gene Ontology 15
      Phenotypes 38
    • Earliest
      J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
    • Latest
      J:264270 Zhou Y, et al., Epha2 and Efna5 participate in lens cell pattern-formation. Differentiation. 2018 Jul - Aug;102:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory