About   Help   FAQ
Epha2
Gene Detail
Symbol

Name
ID
Epha2
Eph receptor A2
MGI:95278
Synonyms
Eck, Myk2, Sek2, Sek-2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
73.67 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:141301240-141329384 bp, + strand
From VEGA annotation of GRCm38

  28145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: EPHA2
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha2

Human
homologs
EPHA2, EPH receptor A2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1969
neXtProt AC: NX_P29317

Human Synonyms: ARCC2, CTPA, CTPP1, CTRCT6, ECK

Human Chr (Location): 1p36; chr1:16124337-16156087 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EPHA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(94) : Gene trapped(89) Targeted(5)
Genomic Mutations involving Epha2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.
 
Human Diseases Modeled in Mice Using Epha2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Epha2 interacts with 128 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process activation of GTPase activity, angiogenesis, ...
Component cell junction, cell projection, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (239)    Tissues (123)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 210
Northern blot 12
Western blot 1
RT-PCR 10
cDNA source data(60)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase epha2 ; ZFIN epha2a, epha2b    NEW 
Molecular
reagents
All nucleic(69) cDNA(62) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010200 (Evidence)
Ensembl Gene Model ENSMUSG00000006445 (Evidence)
Entrez Gene 13836 (Evidence)
UniGene 2581
DFCI TC1579720, TC1590553
DoTS DT.101377004, DT.97413540
NIA Mouse Gene Index U005038
EC 2.7.10.1
Consensus CDS Project CCDS18869.1
International Mouse Phenotyping Consortium Status Epha2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010200 VEGA Gene Model | MGI Sequence Detail 28145 C57BL/6J ±  kb
transcript OTTMUST00000023711 VEGA | MGI Sequence Detail 3913 Not Applicable 
polypeptide OTTMUSP00000010843 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR027936 Ephrin receptor, transmembrane domain
InterPro IPR016257 Ephrin receptor type-A /type-B
InterPro IPR003961 Fibronectin type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007122 ephrin type-A receptor 2
References
(Earliest) J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
(Latest) J:219831 Youngblood V, et al., Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol Cancer Res. 2015 Mar;13(3):524-37
All references(119)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9293, MGI:2140587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory