Epha2
Gene Detail

Symbol Name ID

Epha2 Eph receptor A2 MGI:95278

Synonyms

Eck, Myk2, Sek2, Sek-2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

73.67 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:141301240-141329384 bp, + strand From VEGA annotation of GRCm38   28145 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha2

Human homologs

Human Homolog		EPHA2, EPH receptor A2
NCBI Gene ID		1969
neXtProt AC		NX_P29317
Human Synonyms		ARCC2, CTPA, CTPP1, ECK
Human Chr (Location)		1p36; chr1:16450832-16482582 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human EPHA2

Alleles and phenotypes

All alleles(93) : Targeted(4) Gene trapped(89)
 

Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.

 
Human Diseases Modeled Using Mouse Epha2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	activation of Rac GTPase activity, angiogenesis, ...
Component	cell junction, cell projection, ...
Function	ATP binding, ephrin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (230)    Tissues (118)    Images (94)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	209
Northern blot	12
Western blot	1
RT-PCR	8

cDNA source data(60)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(68) cDNA(62) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010200 (Evidence)
Ensembl Gene Model	ENSMUSG00000006445 (Evidence)
Entrez Gene	13836 (Evidence)
UniGene	2581
DFCI	TC1579720, TC1590553
DoTS	DT.101377004, DT.97413540
NIA Mouse Gene Index	U005038
EC	2.7.10.1
Consensus CDS Project	CCDS18869.1
International Mouse Knockout Project Status	Epha2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010200	VEGA Gene Model | MGI Sequence Detail	28145	C57BL/6J
transcript	OTTMUST00000023711	VEGA | MGI Sequence Detail	3913	Not Applicable
polypeptide	OTTMUSP00000010843	VEGA | MGI Sequence Detail	977	Not Applicable

All sequences(37) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(133 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001090	Ephrin receptor ligand binding domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016257	Tyrosine-protein kinase, ephrin receptor
InterPro	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology	PR:000007122	ephrin type-A receptor 2

References

(Earliest) J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
(Latest) J:191913 Carpenter TC, et al., Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan;46(1):40-7
All references(112)

Other accession IDs

MGD-MRK-9293, MGI:2140587