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Epha2 Gene Detail
Summary
  • Symbol
    Epha2
  • Name
    Eph receptor A2
  • Synonyms
    Eck, Myk2, Sek2, Sek-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95278
    NCBI Gene: 13836
  • Gene Overview
    MyGene.info: EPHA2
Location & Maps
more
  • Sequence Map
    Chr4:141301240-141329384 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28145 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EPHA2, EPH receptor A2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHA2, EPH receptor A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARCC2, CTPA, CTPP1, CTRCT6, ECK
  • Links
    NCBI Gene ID: 1969
    neXtProt AC: NX_P29317

  • Chr Location
    1p36; chr1:16124337-16156087 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Epha2 mouse models; 1 with human EPHA2 associations

Human Disease Mouse Models
       Cataract 6, Multiple Types; CTRCT6   OMIM: 116600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 5 genetic backgrounds
    3 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    96
  • Chemically induced (other)
    2
  • Gene trapped
    89
  • Targeted
    5
  • Genomic Mutations
    3 involving Epha2
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010200 VEGA Gene Model | MGI Sequence Detail 28145 C57BL/6J ±  kb
transcript OTTMUST00000023711 VEGA | MGI Sequence Detail 3913 Not Applicable  
polypeptide OTTMUSP00000010843 VEGA | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    269 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007122 ephrin type-A receptor 2
  • EC
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR003961 Fibronectin type III
    IPR008979 Galactose-binding domain-like
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
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  • All nucleic 69
    cDNA 62
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9293, MGI:2140587
References
more
  • Summaries
    All 117
    Developmental Gene Expression 43
    Diseases 1
    Gene Ontology 12
    Phenotypes 33
  • Earliest
    J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
  • Latest
    J:219831 Youngblood V, et al., Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol Cancer Res. 2015 Mar;13(3):524-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory