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Epha2
Gene Detail
Symbol

Name
ID
Epha2
Eph receptor A2
MGI:95278
Synonyms
Eck, Myk2, Sek2, Sek-2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
73.67 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:141301240-141329384 bp, + strand
From VEGA annotation of GRCm38

  28145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha2

Human
homologs
Human Homolog EPHA2, EPH receptor A2
NCBI Gene ID 1969
neXtProt AC  NX_P29317
Human Synonyms  ARCC2, CTPA, CTPP1, CTRCT6, ECK
Human Chr (Location)  1p36; chr1:16124337-16156087 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EPHA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(93) : Gene trapped(89) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.
 
Human Diseases Modeled Using Mouse Epha2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Epha2 interacts with 128 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process activation of Rac GTPase activity, angiogenesis, ...
Component cell junction, cell projection, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (239)    Tissues (123)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 210
Northern blot 12
Western blot 1
RT-PCR 10
cDNA source data(60)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(62) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010200 (Evidence)
Ensembl Gene ModelENSMUSG00000006445 (Evidence)
Entrez Gene13836 (Evidence)
UniGene2581
DFCITC1590553, TC1579720
DoTSDT.97413540, DT.101377004
NIA Mouse Gene IndexU005038
EC2.7.10.1
Consensus CDS ProjectCCDS18869.1
International Mouse Knockout Project StatusEpha2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010200 VEGA Gene Model | MGI Sequence Detail 28145 C57BL/6J ±  kb
transcript OTTMUST00000023711 VEGA | MGI Sequence Detail 3913 Not Applicable 
polypeptide OTTMUSP00000010843 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007122 ephrin type-A receptor 2
References
(Earliest) J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
(Latest) J:212762 Amato KR, et al., Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. J Clin Invest. 2014 May 1;124(5):2037-49
All references(118)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9293, MGI:2140587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory