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Dpp6
Gene Detail
 Symbol
Name
ID
Dpp6
dipeptidylpeptidase 6
MGI:94921
Synonyms B930011P16Rik, Dpp-6, In(5)6H-p, LOC384168, Peplb, Rw
Feature Type protein coding gene
Genetic Map
Chromosome 5
12.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr5:26817203-27727505 bp, + strand
From VEGA annotation of GRCm38

  910303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dipeptidyl-peptidase IV
Gene Tree: Dpp6

Human
homologs
Human Homolog DPP6, dipeptidyl-peptidase 6
NCBI Gene ID 1804
neXtProt AC  NX_P42658
Human Synonyms  DPPX, VF2
Human Chr (Location)  7q36.2; chr7:153748189-154894285 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DPP6
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Radiation induced(3) Targeted(3)
Genomic Mutations involving Dpp6 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit loss of A-type K+ current gradients in distal dendrites.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dpp6 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process neuronal action potential, positive regulation of potassium ion transmembrane transport, ...
Component cell surface, extracellular vesicular exosome, ...
Function protein binding, serine-type peptidase activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (337)    Tissues (121)    Images (44)
Theiler Stages: 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 310
RT-PCR 27
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(1) cDNA(58) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029575 (Evidence)
Ensembl Gene ModelENSMUSG00000061576 (Evidence)
Entrez Gene13483 (Evidence)
UniGene42078
DFCITC1579126, TC1592330, TC1593441, TC1616145, TC1620169
DoTSDT.101380201, DT.101380202, DT.110682413, DT.55141338, DT.91325718, DT.94252090
NIA Mouse Gene IndexU005379, U331525
Consensus CDS ProjectCCDS19139.1, CCDS51446.1, CCDS51447.1, CCDS57332.1
International Mouse Knockout Project StatusDpp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029575 VEGA Gene Model | MGI Sequence Detail 910303 C57BL/6J ±  kb
transcript OTTMUST00000073343 VEGA | MGI Sequence Detail 4720 Not Applicable 
polypeptide OTTMUSP00000037942 VEGA | MGI Sequence Detail 859 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(10) UniProt(7)
Polymorphisms RFLP(5) : SNPs within 2kb(9067 from dbSNP Build 137)    SNPs within 2kb including multiple locations(9111)
Protein-related
information
ResourceIDDescription
InterPro IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
Protein Ontology PR:000006661 dipeptidyl aminopeptidase-like protein 6
References (Earliest) J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
(Latest) J:207227 Mercer RC, et al., The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27;288(52):37241-55
All references(62)
Other
accession IDs
MGD-MRK-16624, MGD-MRK-8886, MGD-MRK-8889, MGI:1349384, MGI:2686223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory