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Dpp6 Gene Detail
Summary
  • Symbol
    Dpp6
  • Name
    dipeptidylpeptidase 6
  • Synonyms
    B930011P16Rik, Dpp-6, In(5)6H-p, LOC384168, Peplb, Rw
  • Feature Type
    protein coding gene
  • IDs
    MGI:94921
    NCBI Gene: 13483
  • Gene Overview
    MyGene.info: DPP6
Location & Maps
more
  • Sequence Map
    Chr5:26817203-27727505 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      910303 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 12.92 cM
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    DPP6, dipeptidyl peptidase like 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPP6, dipeptidyl peptidase like 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DPL1, DPPX, MRD33, VF2
  • Links
    NCBI Gene ID: 1804
    neXtProt AC: NX_P42658

  • Chr Location
    7q36.2; chr7:153887097-154894290 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human DPP6 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 33; MRD33   OMIM: 616311
Ventricular Fibrillation, Paroxysmal Familial, 2; VF2   OMIM: 612956
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    8 involving Dpp6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit loss of A-type K+ current gradients in distal dendrites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029575 VEGA Gene Model | MGI Sequence Detail 910303 C57BL/6J ±  kb
transcript OTTMUST00000073343 VEGA | MGI Sequence Detail 4720 Not Applicable  
polypeptide OTTMUSP00000037942 VEGA | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8805 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 63
    Genomic 1
    cDNA 58
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16624, MGD-MRK-8886, MGD-MRK-8889, MGI:1349384, MGI:2686223
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 8
    Phenotypes 33
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:236316 Williamson I, et al., Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity. Development. 2016 Aug 15;143(16):2994-3001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory