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Dpp6
Gene Detail
Symbol

Name
ID
Dpp6
dipeptidylpeptidase 6
MGI:94921
Synonyms
B930011P16Rik, Dpp-6, In(5)6H-p, LOC384168, Peplb, Rw
Feature Type
protein coding gene
Genetic Map
Chromosome 5
12.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr5:26817203-27727505 bp, + strand
From VEGA annotation of GRCm38

  910303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DPP6
Protein SuperFamily: dipeptidyl-peptidase IV
Gene Tree: Dpp6

Human
homologs
DPP6, dipeptidyl-peptidase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1804
neXtProt AC: NX_P42658

Human Synonyms: DPPX, MRD33, VF2

Human Chr (Location): 7q36.2; chr7:153887097-154894290 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DPP6

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Radiation induced(4) Targeted(3)
Genomic Mutations involving Dpp6 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit loss of A-type K+ current gradients in distal dendrites.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Dpp6 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (337)    Tissues (124)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 310
RT-PCR 27
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dpp6    NEW 
Molecular
reagents
All nucleic(63) Genomic(1) cDNA(58) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029575 (Evidence)
Ensembl Gene Model ENSMUSG00000061576 (Evidence)
Entrez Gene 13483 (Evidence)
UniGene 42078
DFCI TC1579126, TC1592330, TC1593441, TC1616145, TC1620169
DoTS DT.101380201, DT.101380202, DT.110682413, DT.55141338, DT.91325718, DT.94252090
NIA Mouse Gene Index U005379, U331525
Consensus CDS Project CCDS19139.1, CCDS51446.1, CCDS51447.1, CCDS57332.1
International Mouse Phenotyping Consortium Status Dpp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029575 VEGA Gene Model | MGI Sequence Detail 910303 C57BL/6J ±  kb
transcript OTTMUST00000073343 VEGA | MGI Sequence Detail 4720 Not Applicable 
polypeptide OTTMUSP00000037942 VEGA | MGI Sequence Detail 859 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(5) : SNPs within 2kb(9067 from dbSNP Build 137)    SNPs within 2kb including multiple locations(9111)
Protein-related
information
ResourceIDDescription
InterPro IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
Protein Ontology PR:000006661 dipeptidyl aminopeptidase-like protein 6
References
(Earliest) J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
(Latest) J:210579 Maffie JK, et al., Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591(Pt 10):2419-27
All references(61)
Other
accession IDs
MGD-MRK-16624, MGD-MRK-8886, MGD-MRK-8889, MGI:1349384, MGI:2686223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory