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Dlx2
Gene Detail
Symbol

Name
ID
Dlx2
distal-less homeobox 2
MGI:94902
Synonyms
DII A, Dlx-2, Tes-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:71543408-71546754 bp, - strand
From VEGA annotation of GRCm38

  3347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DLX2
Gene Tree: Dlx2

Human
homologs
DLX2, distal-less homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1746
neXtProt AC: NX_Q07687

Human Synonyms: TES1, TES-1

Human Chr (Location): 2q32; chr2:172099438-172102750 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Dlx2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx1 null allele, maxillary molar teeth are missing.
 
Interactions
Dlx2 interacts with 170 markers (Mir7-1, Mir10a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process branching morphogenesis of a nerve, cartilage development, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (266 records)
Data Summary: Results (872)    Tissues (453)    Images (258)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 712
In situ reporter (knock in) 26
Northern blot 30
RT-PCR 20
RNase protection 5
cDNA source data(37)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dlx2 ; ZFIN dlx2a, dlx2b    NEW 
Molecular
reagents
All nucleic(66) Genomic(2) cDNA(42) Primer pair(7) Other(15)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000013199 (Evidence)
Ensembl Gene Model ENSMUSG00000023391 (Evidence)
Entrez Gene 13392 (Evidence)
UniGene 3896
DFCI TC1582578
DoTS DT.40140175
NIA Mouse Gene Index U022729
Consensus CDS Project CCDS16117.1
International Mouse Phenotyping Consortium Status Dlx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013199 VEGA Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
transcript OTTMUST00000031897 VEGA | MGI Sequence Detail 2473 Not Applicable 
polypeptide OTTMUSP00000014201 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006528 homeobox protein DLX-2
References
(Earliest) J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(321)
Other
accession IDs
MGD-MRK-8858, MGD-MRK-8862, MGI:2139313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory