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Dlx2
Gene Detail
Symbol

Name
ID
Dlx2
distal-less homeobox 2
MGI:94902
Synonyms
DII A, Dlx-2, Tes-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:71543408-71546754 bp, - strand
From VEGA annotation of GRCm38

  3347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Dlx2

Human
homologs
Human Homolog DLX2, distal-less homeobox 2
NCBI Gene ID 1746
neXtProt AC  NX_Q07687
Human Synonyms  TES1, TES-1
Human Chr (Location)  2q32; chr2:172099438-172102750 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Dlx2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx1 null allele, maxillary molar teeth are missing.
 
Interactions
Dlx2 interacts with 170 markers (Mir7-1, Mir10a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process branching morphogenesis of a nerve, cartilage development, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (258 records)
Data Summary: Results (872)    Tissues (453)    Images (258)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 712
In situ reporter (knock in) 26
Northern blot 30
RT-PCR 20
RNase protection 5
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) Genomic(2) cDNA(42) Primer pair(7) Other(15)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013199 (Evidence)
Ensembl Gene ModelENSMUSG00000023391 (Evidence)
Entrez Gene13392 (Evidence)
UniGene3896
DFCITC1582578
DoTSDT.40140175
NIA Mouse Gene IndexU022729
Consensus CDS ProjectCCDS16117.1
International Mouse Knockout Project StatusDlx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013199 VEGA Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
transcript OTTMUST00000031897 VEGA | MGI Sequence Detail 2473 Not Applicable 
polypeptide OTTMUSP00000014201 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022135 Distal-less-like homeobox protein, N-terminal domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006528 homeobox protein DLX-2
References
(Earliest) J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
(Latest) J:213589 Ono K, et al., Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2. Development. 2014 May;141(10):2075-84
All references(317)
Other
accession IDs
MGD-MRK-8858, MGD-MRK-8862, MGI:2139313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory