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Dlx2 Gene Detail
Summary
  • Symbol
    Dlx2
  • Name
    distal-less homeobox 2
  • Synonyms
    DII A, Dlx-2, Tes-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94902
    NCBI Gene: 13392
Location & Maps
more
  • Sequence Map
    Chr2:71543408-71546754 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3347 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLX2, distal-less homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLX2, distal-less homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TES1, TES-1
  • Links
    NCBI Gene ID: 1746
    neXtProt AC: NX_Q07687

  • Chr Location
    2q32; chr2:172099438-172102750 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3244
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: DLX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Dlx2
  • Incidental Mutations
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx1 null allele, maxillary molar teeth are missing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013199 VEGA Gene Model | MGI Sequence Detail 3347 C57BL/6J ±  kb
transcript OTTMUST00000031897 VEGA | MGI Sequence Detail 2473 Not Applicable  
polypeptide OTTMUSP00000014201 VEGA | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    Genomic 2
    cDNA 46
    Primer pair 7
    Other 18

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-8858, MGD-MRK-8862, MGI:2139313
References
more
  • Summaries
    All 322
    Developmental Gene Expression 270
    Gene Ontology 16
    Phenotypes 48
  • Earliest
    J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
  • Latest
    J:226834 Jones I, et al., A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015 Dec 1;8(12):1517-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory