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Mknk2 Gene Detail
Summary
  • Symbol
    Mknk2
  • Name
    MAP kinase-interacting serine/threonine kinase 2
  • Synonyms
    2010016G11Rik, Mnk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894279
    NCBI Gene: 17347
  • Gene Overview
    MyGene.info: MKNK2
Location & Maps
more
  • Sequence Map
    Chr10:80665327-80678112 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MKNK2, MAP kinase interacting serine/threonine kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MKNK2, MAP kinase interacting serine/threonine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPRK7, MNK2
  • Links
    NCBI Gene ID: 2872
    neXtProt AC: NX_Q9HBH9

  • Chr Location
    19p13.3; chr19:2037471-2051244 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 49674
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MKNK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    18 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Mknk2
  • Incidental Mutations
Homozygous null mice are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054816 VEGA Gene Model | MGI Sequence Detail 12786 C57BL/6J ±  kb
transcript OTTMUST00000135837 VEGA | MGI Sequence Detail 3439 Not Applicable  
polypeptide OTTMUSP00000071811 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1916453
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:40024 Waskiewicz AJ, et al., Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20
  • Latest
    J:221371 Beggs JE, et al., The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding. Biochem J. 2015 Apr 1;467(1):63-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory