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Dnajc5 Gene Detail
Summary
  • Symbol
    Dnajc5
  • Name
    DnaJ heat shock protein family (Hsp40) member C5
  • Synonyms
    2610314I24Rik, Csp
  • Feature Type
    protein coding gene
  • IDs
    MGI:892995
    NCBI Gene: 13002
  • Gene Overview
    MyGene.info: DNAJC5
Location & Maps
more
  • Sequence Map
    Chr2:181520485-181555133 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34649 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.63 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DNAJC5, DnaJ heat shock protein family (Hsp40) member C5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJC5, DnaJ heat shock protein family (Hsp40) member C5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLN4, CLN4B, CSP, DNAJC5A, mir-941-2, mir-941-3, mir-941-4, mir-941-5, NCL
  • Links
    NCBI Gene ID: 80331
    neXtProt AC: NX_Q9H3Z4

  • Chr Location
    20q13.33; chr20:63895102-63936031 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    45
  • Targeted
    2
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene die within the first 3 months of live and abnormalities in their neuromuscular synapses. This results in various defects in movement and coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016739 VEGA Gene Model | MGI Sequence Detail 34649 C57BL/6J ±  kb
transcript OTTMUST00000040587 VEGA | MGI Sequence Detail 3664 Not Applicable  
polypeptide OTTMUSP00000018140 VEGA | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Other 1

    Microarray probesets 10
Other
Accession IDs
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MGI:1919766, MGI:2139168
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:37096 Chin H, et al., Genetic mapping of the gene encoding cysteine string protein. Mamm Genome. 1997 Jun;8(6):456-7
  • Latest
    J:221517 Lemonidis K, et al., The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Mol Biol Cell. 2014 Dec 1;25(24):3870-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory