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Dnajc5
Gene Detail
Symbol

Name
ID
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
MGI:892995
Synonyms
2610314I24Rik, Csp
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:181520485-181555133 bp, + strand
From VEGA annotation of GRCm38

  34649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: DNAJC5
Protein SuperFamily: cysteine string protein
Gene Tree: Dnajc5

Human
homologs
DNAJC5, DnaJ (Hsp40) homolog, subfamily C, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80331
neXtProt AC: NX_Q9H3Z4

Human Synonyms: CLN4, CLN4B, CSP, DNAJC5A, mir-941-2, mir-941-3, mir-941-4, mir-941-5, NCL

Human Chr (Location): 20q13.33; chr20:63895102-63936031 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNAJC5

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(45) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die within the first 3 months of live and abnormalities in their neuromuscular synapses. This results in various defects in movement and coordination.
 
Phenotype Images(2)
Interactions
Dnajc5 interacts with 459 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of neuron apoptotic process
Component extracellular exosome, lysosomal membrane, ...
Function ATP-dependent protein binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC548742 ; ZFIN dnajc5aa, dnajc5ab    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000016739 (Evidence)
Ensembl Gene Model ENSMUSG00000000826 (Evidence)
Entrez Gene 13002 (Evidence)
DFCI TC1601668, TC1577904, TC1601850, TC1719080, TC1608598
DoTS DT.101282068, DT.534204, DT.101399117, DT.110731710, DT.101399124, DT.101399118
NIA Mouse Gene Index U002987
PDB 2CTW
Consensus CDS Project CCDS17215.1
International Mouse Phenotyping Consortium Status Dnajc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016739 VEGA Gene Model | MGI Sequence Detail 34649 C57BL/6J ±  kb
transcript OTTMUST00000040588 VEGA | MGI Sequence Detail 934 Not Applicable 
polypeptide OTTMUSP00000018141 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(12) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001623 DnaJ domain
InterPro IPR018253 DnaJ domain, conserved site
Protein Ontology PR:000006588 DnaJ homolog subfamily C member 5
References
(Earliest) J:37096 Chin H, et al., Genetic mapping of the gene encoding cysteine string protein. Mamm Genome. 1997 Jun;8(6):456-7
(Latest) J:221517 Lemonidis K, et al., The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Mol Biol Cell. 2014 Dec 1;25(24):3870-83
All references(58)
Other
accession IDs
MGI:1919766, MGI:2139168

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory