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Klk1b1
Gene Detail
Symbol

Name
ID
Klk1b1
kallikrein 1-related peptidase b1
MGI:892019
Synonyms
Klk1, mGK-1, mK1, tissue kallikrein, TK
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:43966768-43971316 bp, + strand
From NCBI annotation of GRCm38

  4549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b1

Human
homologs
Human Homolog KLK3, kallikrein-related peptidase 3
NCBI Gene ID 354
neXtProt AC  NX_P07288
Human Synonyms  APS, hK3, KLK2A1, PSA
Human Chr (Location)  19q13.41; chr19:50854915-50860764 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased left ventricular contractility, cardiac output, and stroke volume, a thin left ventricular wall, and impaired vasodilation.
 
Interactions
Klk1b1 interacts with 10 markers (Mir194-2, Mir448, Mir546, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process bradykinin biosynthetic process, cardiac muscle contraction, ...
Component extracellular vesicular exosome, nucleus
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(82) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000063133 (Evidence)
Entrez Gene16623 (Evidence)
UniGene447819
DFCITC1588398
NIA Mouse Gene IndexU157021
EC3.4.21.35
Consensus CDS ProjectCCDS21190.1
International Mouse Knockout Project StatusKlk1b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16623 NCBI Gene Model | MGI Sequence Detail 4549 C57BL/6J ±  kb
transcript NM_010645 RefSeq | MGI Sequence Detail 878 FVB/N 
polypeptide P00755 UniProt | EBI | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(304 from dbSNP Build 137)    SNPs within 2kb including multiple locations(314)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009603 kallikrein 1-related peptidase b1
Graphical View of Protein Domain Structure
References
(Earliest) J:32312 Richards RI, et al., Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases. J Biol Chem. 1982 Mar 25;257(6):2758-61
(Latest) J:189099 Waeckel L, et al., Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse. Endocrinology. 2012 Aug;153(8):3886-96
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory