Klk1b1
Gene Detail

Symbol Name ID

Klk1b1 kallikrein 1-related peptidase b1 MGI:892019

Synonyms

Klk1, mGK-1, mK1, tissue kallikrein, TK

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr7:43966768-43971316 bp, + strand From NCBI annotation of GRCm38   4549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b1

Human homologs

Human Homolog		KLK3, kallikrein-related peptidase 3
NCBI Gene ID		354
neXtProt AC		NX_P07288
Human Synonyms		APS, hK3, KLK2A1, PSA
Human Chr (Location)		19q13.41; chr19:51358171-51364020 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice display decreased left ventricular contractility, cardiac output, and stroke volume, a thin left ventricular wall, and impaired vasodilation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	bradykinin biosynthetic process, cardiac muscle contraction, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(92) Genomic(82) cDNA(9) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000063133 (Evidence)
Entrez Gene	16623 (Evidence)
UniGene	447819
DFCI	TC1588398
NIA Mouse Gene Index	U157021
EC	3.4.21.35
Consensus CDS Project	CCDS21190.1
International Mouse Knockout Project Status	Klk1b1

Sequences

Length	Strain/Species
genomic	16623	NCBI Gene Model | MGI Sequence Detail	4549	C57BL/6J
transcript	NM_010645	RefSeq | MGI Sequence Detail	878	FVB/N
polypeptide	P00755	UniProt | EBI | MGI Sequence Detail	261	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000009603	kallikrein 1-related peptidase b1

Graphical View of Protein Domain Structure

References

(Earliest) J:32312 Richards RI, et al., Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases. J Biol Chem. 1982 Mar 25;257(6):2758-61
(Latest) J:189099 Waeckel L, et al., Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse. Endocrinology. 2012 Aug;153(8):3886-96
All references(45)