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Klk1b1 Gene Detail
Summary
  • Symbol
    Klk1b1
  • Name
    kallikrein 1-related peptidase b1
  • Synonyms
    Klk1, mGK-1, mK1, tissue kallikrein, TK
  • Feature Type
    protein coding gene
  • IDs
    MGI:892019
    NCBI Gene: 16623
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43966751-43971318 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.44 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892019
protein coding gene Chr7:43966751-43971318 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032150
protein coding gene Chr7:44026918-44031889 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0032067
protein coding gene Chr7:44495725-44500292 (+)
BALB/cJ MGP_BALBcJ_G0032142
protein coding gene Chr7:43312955-43317518 (+)
C3H/HeJ MGP_C3HHeJ_G0031857
protein coding gene Chr7:44992789-44997356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032624
protein coding gene Chr7:46265988-46275779 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029652
protein coding gene Chr7:45867182-45871713 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031976
protein coding gene Chr7:42911413-42915983 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0032052
protein coding gene Chr7:44763092-44769353 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032645
protein coding gene Chr7:43622722-43627293 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030746
protein coding gene Chr7:31661862-31663937 (+)
WSB/EiJ MGP_WSBEiJ_G0031304
protein coding gene Chr7:44189955-44192005 (+)



Homology
more
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
  • Vertebrate Orthologs
    16
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
    Orthology source: HomoloGene
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288
    UniProt: P07288

  • Chr Location
    19q13.33; chr19:50854915-50860764 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased left ventricular contractility, cardiac output, and stroke volume, a thin left ventricular wall, and impaired vasodilation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16623 NCBI Gene Model | MGI Sequence Detail 4568 C57BL/6J ±  kb
transcript NM_010645 RefSeq | MGI Sequence Detail 867 C57BL/6  
polypeptide P00755 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    Genomic 82
    cDNA 10
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 49
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:32312 Richards RI, et al., Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases. J Biol Chem. 1982 Mar 25;257(6):2758-61
  • Latest
    J:256467 Desposito D, et al., Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice. Sci Rep. 2017 Aug 25;7(1):9410

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory