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Phyh
Gene Detail
 Symbol
Name
ID
Phyh
phytanoyl-CoA hydroxylase
MGI:891978
Synonyms Lnap1
Feature Type protein coding gene
Genetic Map
Chromosome 2
3.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:4919019-4938730 bp, + strand
From VEGA annotation of GRCm38

  19712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog; 1 chicken; 2 zebrafish

Gene Tree: Phyh

Human
homologs
Human Homolog PHYH, phytanoyl-CoA 2-hydroxylase
NCBI Gene ID 5264
neXtProt AC  NX_O14832
Human Synonyms  LN1, LNAP1, PAHX, PHYH1, RD
Human Chr (Location)  10p13; chr10:13277796-13300138 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
When fed a high phytol diet, mice homozygous for a null allele exhibit hepatic lipidosis and steatosis, ataxia, peripheral neuropathy and loss of spermatogonia.
 
Human Diseases Modeled Using Mouse Phyh (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid alpha-oxidation, isoprenoid metabolic process, ...
Component mitochondrion, peroxisome
Function catalytic activity, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (241)    Tissues (133)    Images (32)
Theiler Stages: 15, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 195
Northern blot 46
cDNA source data(172)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(172) cDNA(172)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010818 (Evidence)
Ensembl Gene ModelENSMUSG00000026664 (Evidence)
Entrez Gene16922 (Evidence)
UniGene391704
DFCITC1572811
DoTSDT.101387444, DT.535220
NIA Mouse Gene IndexU001346
EC1.14.11.18
Consensus CDS ProjectCCDS15660.1
International Mouse Knockout Project StatusPhyh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010818 VEGA Gene Model | MGI Sequence Detail 19712 C57BL/6J ±  kb
transcript OTTMUST00000025296 VEGA | MGI Sequence Detail 1438 Not Applicable 
polypeptide OTTMUSP00000011598 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008775 Phytanoyl-CoA dioxygenase
Protein Ontology PR:000012674 phytanoyl-CoA dioxygenase, peroxisomal
References (Earliest) J:37950 Iwano M, et al., Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse. Biochem Biophys Res Commun. 1996 Dec 4;229(1):355-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:2138869, MGI:2138872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory