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Phyh
Gene Detail
Symbol

Name
ID
Phyh
phytanoyl-CoA hydroxylase
MGI:891978
Synonyms
Lnap1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
3.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:4919019-4938730 bp, + strand
From VEGA annotation of GRCm38

  19712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PHYH
Gene Tree: Phyh

Human
homologs
PHYH, phytanoyl-CoA 2-hydroxylase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5264
neXtProt AC: NX_O14832

Human Synonyms: LN1, LNAP1, PAHX, PHYH1, RD

Human Chr (Location): 10p13; chr10:13277796-13300138 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PHYH

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
When fed a high phytol diet, mice homozygous for a null allele exhibit hepatic lipidosis and steatosis, ataxia, peripheral neuropathy and loss of spermatogonia.
 
Human Diseases Modeled in Mice Using Phyh (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Phyh interacts with 55 markers (Mir1a-1, Mir1a-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid alpha-oxidation, isoprenoid metabolic process, ...
Component mitochondrion, peroxisome
Function catalytic activity, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (241)    Tissues (142)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 195
Northern blot 46
cDNA source data(172)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase phyh ; ZFIN phyh    NEW 
Molecular
reagents
All nucleic(172) cDNA(172)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010818 (Evidence)
Ensembl Gene Model ENSMUSG00000026664 (Evidence)
Entrez Gene 16922 (Evidence)
UniGene 391704
DFCI TC1572811
DoTS DT.535220, DT.101387444
NIA Mouse Gene Index U001346
EC 1.14.11.18
Consensus CDS Project CCDS15660.1
International Mouse Phenotyping Consortium Status Phyh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010818 VEGA Gene Model | MGI Sequence Detail 19712 C57BL/6J ±  kb
transcript OTTMUST00000025296 VEGA | MGI Sequence Detail 1438 Not Applicable 
polypeptide OTTMUSP00000011598 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008775 Phytanoyl-CoA dioxygenase
Protein Ontology PR:000012674 phytanoyl-CoA dioxygenase, peroxisomal
References
(Earliest) J:37950 Iwano M, et al., Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse. Biochem Biophys Res Commun. 1996 Dec 4;229(1):355-60
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:2138869, MGI:2138872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory