Serpina1c
Gene Detail

Symbol Name ID

Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C MGI:891969

Synonyms

PI3, PI6, Spi1-3, Spi1-6

Feature Type

protein coding gene

Genetic Map

Chromosome 12

52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:103894926-103904887 bp, - strand From VEGA annotation of GRCm38   9962 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20103  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 5 chicken; 2 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpina1c

Human homologs

Human Homolog		SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
NCBI Gene ID		5265
neXtProt AC		NX_P01009
Human Synonyms		A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
Human Chr (Location)		14q32.1; chr14:94843084-94857029 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SERPINA1

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	extracellular region, extracellular space
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (58)    Tissues (8)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	58

cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023935 (Evidence)
Ensembl Gene Model	ENSMUSG00000079015 (Evidence)
Entrez Gene	20702 (Evidence)
Consensus CDS Project	CCDS26141.1
International Mouse Knockout Project Status	Serpina1c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023935	VEGA Gene Model | MGI Sequence Detail	9962	C57BL/6J
transcript	OTTMUST00000058482	VEGA | MGI Sequence Detail	1361	Not Applicable
polypeptide	OTTMUSP00000028336	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(3) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000015929	alpha-1-antitrypsin 1-3

References

(Earliest) J:19360 Hill RE, et al., Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions. Nature. 1984 Sep 13-19;311(5982):175-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Other accession IDs

MGI:891966