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Serpina1c Gene Detail
Summary
  • Symbol
    Serpina1c
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1C
  • Synonyms
    PI3, PI6, Spi1-3, Spi1-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:891969
    NCBI Gene: 20702
  • Gene Overview
    MyGene.info: SERPINA1
Location & Maps
more
  • Sequence Map
    Chr12:103894926-103904887 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9962 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.98 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    SERPINA1, serpin family A member 1
    Orthology source: HomoloGene
  • Synonyms
    A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
  • Links
    NCBI Gene ID: 5265
    neXtProt AC: NX_P01009

  • Chr Location
    14q32.1; chr14:94376747-94390692 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SERPINA1 associations

Human Disease Mouse Models
       Alpha-1-Antitrypsin Deficiency; A1ATD   OMIM: 613490
Pulmonary Disease, Chronic Obstructive; COPD   OMIM: 606963
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Serpina1c
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023935 VEGA Gene Model | MGI Sequence Detail 9962 C57BL/6J ±  kb
transcript OTTMUST00000058482 VEGA | MGI Sequence Detail 1361 Not Applicable  
polypeptide OTTMUSP00000028336 VEGA | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:891966
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:19360 Hill RE, et al., Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions. Nature. 1984 Sep 13-19;311(5982):175-7
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory