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Cyp1a1 Gene Detail
Summary
  • Symbol
    Cyp1a1
  • Name
    cytochrome P450, family 1, subfamily a, polypeptide 1
  • Synonyms
    cytochrome P450 subfamily I, polypeptide 1, P450-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88588
    NCBI Gene: 13076
Location & Maps
more
  • Sequence Map
    Chr9:57697613-57703822 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6210 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CYP1A1, cytochrome P450 family 1 subfamily A member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CYP1A1, cytochrome P450 family 1 subfamily A member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
  • Links
    NCBI Gene ID: 1543
    neXtProt AC: NX_P04798

  • Chr Location
    15q24.1; chr15:74719542-74725610 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 5 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Targeted
    13
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cyp1a1
  • Incidental Mutations
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032315 Ensembl Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
transcript ENSMUST00000034865 Ensembl | MGI Sequence Detail 2619 Not Applicable  
polypeptide ENSMUSP00000034865 Ensembl | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    118 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 7
    cDNA 16
    Primer pair 5
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13109, MGD-MRK-2302
References
more
  • Summaries
    All 118
    Developmental Gene Expression 9
    Gene Ontology 14
    Phenotypes 32
  • Earliest
    J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
  • Latest
    J:218526 Henderson CJ, et al., Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability. Biochem J. 2015 Feb 1;465(3):479-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory