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Cyp1a1
Gene Detail
Symbol

Name
ID
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
MGI:88588
STS
Synonyms
cytochrome P450 subfamily I, polypeptide 1, P450-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr9:57697613-57703822 bp, + strand
From Ensembl annotation of GRCm38

  6210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP1A1
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1a1

Human
homologs
CYP1A1, cytochrome P450, family 1, subfamily A, polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1543
neXtProt AC: NX_P04798

Human Synonyms: AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX

Human Chr (Location): 15q24.1; chr15:74719542-74725610 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(13) Transgenic(1)
Genomic Mutations involving Cyp1a1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
 
Interactions
Cyp1a1 interacts with 143 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process 9-cis-retinoic acid biosynthetic process, amine metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function aromatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (140)    Tissues (118)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 46
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyp1a1    NEW 
Molecular
reagents
All nucleic(31) Genomic(7) cDNA(16) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000032315 (Evidence)
Entrez Gene 13076 (Evidence)
UniGene 14089
DFCI TC1582669
DoTS DT.101128428, DT.55165012, DT.94400658
NIA Mouse Gene Index U010552
EC 1.14.14.1
Consensus CDS Project CCDS23230.1
International Mouse Phenotyping Consortium Status Cyp1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032315 Ensembl Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
transcript ENSMUST00000034865 Ensembl | MGI Sequence Detail 2619 Not Applicable 
polypeptide ENSMUSP00000034865 Ensembl | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms
All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR008066 Cytochrome P450, E-class, group I, CYP1
Protein Ontology PR:000006101 cytochrome P450 1A1
References
(Earliest) J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
(Latest) J:218526 Henderson CJ, et al., Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability. Biochem J. 2015 Feb 1;465(3):479-88
All references(119)
Other
accession IDs
MGD-MRK-13109, MGD-MRK-2302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory