Cyp1a1
Gene Detail

Symbol Name ID

Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 MGI:88588

STS

D9Mit28

Synonyms

cytochrome P450 subfamily I, polypeptide 1, P450-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr9:57697613-57703822 bp, + strand From Ensembl annotation of GRCm38   6210 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1a1

Human homologs

Human Homolog		CYP1A1, cytochrome P450, family 1, subfamily A, polypeptide 1
NCBI Gene ID		1543
neXtProt AC		NX_P04798
Human Synonyms		AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
Human Chr (Location)		15q24.1; chr15:75011883-75017877 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.

 

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	9-cis-retinoic acid biosynthetic process, amine metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	aromatase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (119)   
Theiler Stages: 1, 2, 4, 10, 18, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	94
RT-PCR	47

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(7) cDNA(16) Primer pair(5) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032315 (Evidence)
Entrez Gene	13076 (Evidence)
UniGene	14089
DFCI	TC1582669
DoTS	DT.101128428, DT.55165012, DT.94400658
NIA Mouse Gene Index	U010552
EC	1.14.14.1
Consensus CDS Project	CCDS23230.1
International Mouse Knockout Project Status	Cyp1a1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032315	Ensembl Gene Model | MGI Sequence Detail	6210	C57BL/6J
transcript	ENSMUST00000034865	Ensembl | MGI Sequence Detail	2619	Not Applicable
polypeptide	ENSMUSP00000034865	Ensembl | MGI Sequence Detail	524	Not Applicable

All sequences(27) RefSeq(4) UniProt(2)

Polymorphisms

All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
InterPro	IPR008066	Cytochrome P450, E-class, group I, CYP1
Protein Ontology	PR:000006101	cytochrome P450 1A1

References

(Earliest) J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
(Latest) J:193505 Galvez-Peralta M, et al., Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Int J Cancer. 2013 May 1;132(9):2065-75
All references(121)

Other accession IDs

MGD-MRK-13109, MGD-MRK-2302