About   Help   FAQ
Cyp1a1
Gene Detail
 Symbol
Name
ID
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
MGI:88588
STS D9Mit28
Synonyms cytochrome P450 subfamily I, polypeptide 1, P450-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
31.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr9:57697613-57703822 bp, + strand
From Ensembl annotation of GRCm38

  6210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1a1

Human
homologs
Human Homolog CYP1A1, cytochrome P450, family 1, subfamily A, polypeptide 1
NCBI Gene ID 1543
neXtProt AC  NX_P04798
Human Synonyms  AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
Human Chr (Location)  15q24.1; chr15:74719542-74725610 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
 
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process 9-cis-retinoic acid biosynthetic process, amine metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function aromatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (119)   
Theiler Stages: 1, 2, 4, 10, 18, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 47
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) Genomic(7) cDNA(16) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032315 (Evidence)
Entrez Gene13076 (Evidence)
UniGene14089
DFCITC1582669
DoTSDT.101128428, DT.55165012, DT.94400658
NIA Mouse Gene IndexU010552
EC1.14.14.1
Consensus CDS ProjectCCDS23230.1
International Mouse Knockout Project StatusCyp1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032315 Ensembl Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
transcript ENSMUST00000034865 Ensembl | MGI Sequence Detail 2619 Not Applicable 
polypeptide ENSMUSP00000034865 Ensembl | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR008066 Cytochrome P450, E-class, group I, CYP1
Protein Ontology PR:000006101 cytochrome P450 1A1
References (Earliest) J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
(Latest) J:209865 van Voorhis M, et al., Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS One. 2013;8(12):e82545
All references(126)
Other
accession IDs
MGD-MRK-13109, MGD-MRK-2302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory