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Cybb Gene Detail
Summary
  • Symbol
    Cybb
  • Name
    cytochrome b-245, beta polypeptide
  • Synonyms
    Cgd, gp91phox, gp91phox, Nox2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88574
    NCBI Gene: 13058
  • Gene Overview
    MyGene.info: CYBB
Location & Maps
more
  • Genetic Map
    Chromosome X, 4.30 cM
  • Mapping Data
    22 experiments
Homology
more
  • Human Ortholog
    CYBB, cytochrome b-245 beta chain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYBB, cytochrome b-245 beta chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMCBX2, CGD, GP91-1, GP91PHOX, GP91-PHOX, IMD34, NOX2, p91-PHOX
  • Links
    NCBI Gene ID: 1536
    neXtProt AC: NX_P04839
    UniProt: P04839

  • Chr Location
    Xp21.1-p11.4; chrX:37780017-37813461 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 68054
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CYBB
  • Gene Tree
    Cybb
Human Diseases
more
  • Diseases
    1 with Cybb mouse models; 1 with human CYBB associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    331 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    148
  • Tissues
    66
  • cDNA Data
    83
  • Literature Summary
    8
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016894 VEGA Gene Model | MGI Sequence Detail 52520 C57BL/6J ±  kb
transcript OTTMUST00000040996 VEGA | MGI Sequence Detail 4752 Not Applicable  
polypeptide OTTMUSP00000018354 VEGA | MGI Sequence Detail 570 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    226 from dbSNP Build 142
  • RFLP
    3
Protein
Information
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Molecular
Reagents
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  • All nucleic 91
    cDNA 86
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-1965, MGD-MRK-2263, MGI:2148082
References
more
  • Summaries
    All 419
    Developmental Gene Expression 8
    Diseases 3
    Gene Ontology 11
    Phenotypes 331
  • Earliest
    J:9438 Ryder-Cook AS, et al., Localization of the mdx mutation within the mouse dystrophin gene. EMBO J. 1988 Oct;7(10):3017-21
  • Latest
    J:241536 Kapur R, et al., T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood. 2017 May 04;129(18):2557-2569
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory