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Cybb
Gene Detail
 Symbol
Name
ID
Cybb
cytochrome b-245, beta polypeptide
MGI:88574
Synonyms Cgd, gp91phox, gp91phox, Nox2
Feature Type protein coding gene
Genetic Map
Chromosome X
4.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
ChrX:9435252-9487771 bp, - strand
From VEGA annotation of GRCm38

  52520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cybb

Human
homologs
Human Homolog CYBB, cytochrome b-245, beta polypeptide
NCBI Gene ID 1536
neXtProt AC  NX_P04839
Human Synonyms  AMCBX2, CGD, GP91-1, GP91PHOX, GP91-PHOX, NOX2, p91-PHOX
Human Chr (Location)  Xp21.1; chrX:37780017-37813461 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYBB
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses.
 
Human Diseases Modeled Using Mouse Cybb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cybb interacts with 358 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process hydrogen peroxide biosynthetic process, inflammatory response, ...
Component cytoplasm, dendrite, ...
Function electron carrier activity, epoxyqueuosine reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (148)    Tissues (66)    Images (26)
Theiler Stages: 8, 9, 12, 13, 14, 16, 17, 19, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 24
Northern blot 6
RT-PCR 110
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) cDNA(86) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016894 (Evidence)
Ensembl Gene ModelENSMUSG00000015340 (Evidence)
Entrez Gene13058 (Evidence)
UniGene200362
DFCITC1574823, TC1599555, TC1746473
DoTSDT.101165428, DT.101379403, DT.534026
NIA Mouse Gene IndexU039255
EC1.-.-.-
Consensus CDS ProjectCCDS30010.1
International Mouse Knockout Project StatusCybb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016894 VEGA Gene Model | MGI Sequence Detail 52520 C57BL/6J ±  kb
transcript OTTMUST00000040996 VEGA | MGI Sequence Detail 4752 Not Applicable 
polypeptide OTTMUSP00000018354 VEGA | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(8)
Polymorphisms RFLP(3) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000778 Cytochrome b245, heavy chain
InterPro IPR013112 FAD-binding 8
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR013121 Ferric reductase, NAD binding
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000006087 cytochrome b-245 heavy chain
References (Earliest) J:9438 Ryder-Cook AS, et al., Localization of the mdx mutation within the mouse dystrophin gene. EMBO J. 1988 Oct;7(10):3017-21
(Latest) J:211933 Williams CD, et al., Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):122-33
All references(373)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1965, MGD-MRK-2263, MGI:2148082

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory