Cybb MGI Mouse Gene Detail - MGI:88574 - cytochrome b-245, beta polypeptide

Symbol

Cybb
Name

cytochrome b-245, beta polypeptide
Synonyms

Cgd, gp91phox, gp91^phox, Nox2

Feature Type

protein coding gene
IDs

MGI:88574
NCBI Gene: 13058
Gene Overview

MyGene.info: CYBB
Alliance

gene page
Transcription Start Sites

33 TSS

Sequence Map

ChrX:9435252-9487766 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 4.30 cM
Mapping Data

22 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88574	protein coding gene	ChrX:9435252-9487771 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035556	protein coding gene	ChrX:4146699-4201883 (-)
A/J	MGP_AJ_G0035533	protein coding gene	ChrX:4263291-4316617 (-)
AKR/J	MGP_AKRJ_G0035465	protein coding gene	ChrX:4322992-4384770 (-)
BALB/cJ	MGP_BALBcJ_G0035526	protein coding gene	ChrX:4189693-4246630 (-)
C3H/HeJ	MGP_C3HHeJ_G0035243	protein coding gene	ChrX:4286458-4345934 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036056	protein coding gene	ChrX:4228779-4279479 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032925	protein coding gene	ChrX:3510805-3559616 (+)
CAST/EiJ	MGP_CASTEiJ_G0034535	protein coding gene	ChrX:4056000-4103435 (-)
CBA/J	MGP_CBAJ_G0035212	protein coding gene	ChrX:4612821-4666863 (-)
DBA/2J	MGP_DBA2J_G0035365	protein coding gene	ChrX:4194420-4248324 (-)
FVB/NJ	MGP_FVBNJ_G0035312	protein coding gene	ChrX:4009238-4059149 (-)
LP/J	MGP_LPJ_G0035447	protein coding gene	ChrX:4342992-4400853 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035355	protein coding gene	ChrX:4461077-4515978 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036068	protein coding gene	ChrX:4113609-4168649 (-)
PWK/PhJ	MGP_PWKPhJ_G0034235	protein coding gene	ChrX:3690094-3743410 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034076	protein coding gene	ChrX:4222674-4276227 (-)
WSB/EiJ	MGP_WSBEiJ_G0034671	protein coding gene	ChrX:4186528-4239771 (-)

Human Ortholog

CYBB, cytochrome b-245 beta chain

Vertebrate Orthologs

10

Human Ortholog

CYBB, cytochrome b-245 beta chain
Orthology source: HomoloGene, HGNC
Synonyms

AMCBX2, CGD, GP91-1, GP91PHOX, GP91-PHOX, IMD34, NOX2, p91-PHOX
Links

HGNC:2578

NCBI Gene ID: 1536

neXtProt AC: NX_P04839

UniProt: P04839
Chr Location

Xp21.1-p11.4; chrX:37780017-37813461 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68054
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CYBB
Gene Tree

Cybb

Diseases

2 with Cybb mouse models; 2 with human CYBB associations

Human Disease

Mouse Models

chronic granulomatous disease

IDs

View 2 models

systemic lupus erythematosus

IDs

View 1 model

immunodeficiency 34

IDs

X-linked chronic granulomatous disease

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

4 with disease annotations

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Phenotype Summary

75 phenotypes from 3 alleles in 5 genetic backgrounds
8 phenotypes from multigenic genotypes
418 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Targeted

7
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses.

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All GO Annotations

50
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

66
cDNA Data

84
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cybb

ZFIN cybb

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Cybb interacts with 357 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

67
RefSeq

4
UniProt

8
CCDS

CCDS30010.1
UniGene

200362

Ensembl

ENSMUSG00000015340 (Evidence)
NCBI Gene

13058

			Length	Strain/Species	Flank
genomic	13058	NCBI Gene Model \| MGI Sequence Detail	52515	C57BL/6J	± kb
transcript	NM_007807	RefSeq \| MGI Sequence Detail	4750	C57BL/6
polypeptide	Q61093	UniProt \| EBI \| MGI Sequence Detail	570	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006087 cytochrome b-245 heavy chain

(term hierarchy)
EC

1.-.-.-
InterPro Domains

IPR000778 Cytochrome b245, heavy chain

IPR013112 FAD-binding 8

IPR017927 FAD-binding domain, ferredoxin reductase-type

IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

IPR013121 Ferric reductase, NAD binding domain

IPR013130 Ferric reductase transmembrane component-like domain

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 92

cDNA 87

Primer pair 4

Other 1

Microarray probesets 7

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MGD-MRK-1965, MGD-MRK-2263, MGI:2148082

Summaries

All 551

Developmental Gene Expression 10

Diseases 4

Gene Ontology 13

Phenotypes 418
Earliest

J:9438 Ryder-Cook AS, et al., Localization of the mdx mutation within the mouse dystrophin gene. EMBO J. 1988 Oct;7(10):3017-21
Latest

J:299238 Shahraz A, et al., Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. Glia. 2021 Jan;69(1):137-150

TSS for Cybb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162966	ChrX:9469480-9469504 (-)	18,274 bp
Tssr162965	ChrX:9469436-9469446 (-)	18,325 bp
Tssr162964	ChrX:9469288-9469331 (-)	18,456 bp
Tssr162963	ChrX:9469250-9469281 (-)	18,500 bp
Tssr162928	ChrX:9453673-9453769 (-)	34,045 bp
Tssr162927	ChrX:9453627-9453671 (-)	34,117 bp
Tssr162925	ChrX:9449657-9449739 (-)	38,068 bp
Tssr162915	ChrX:9444645-9444714 (-)	43,086 bp
Tssr162914	ChrX:9444582-9444644 (-)	43,153 bp
Tssr162913	ChrX:9444453-9444466 (-)	43,306 bp
Tssr162898	ChrX:9437702-9437713 (-)	50,058 bp
Tssr162897	ChrX:9437678-9437693 (-)	50,080 bp
Tssr162896	ChrX:9437651-9437662 (-)	50,109 bp
Tssr162895	ChrX:9437625-9437635 (-)	50,136 bp
Tssr162894	ChrX:9437565-9437579 (-)	50,194 bp
Tssr162893	ChrX:9437535-9437543 (-)	50,227 bp
Tssr162892	ChrX:9437431-9437438 (-)	50,331 bp
Tssr162891	ChrX:9437378-9437383 (-)	50,385 bp
Tssr162890	ChrX:9437344-9437355 (-)	50,416 bp
Tssr162889	ChrX:9437284-9437285 (-)	50,481 bp
Tssr162888	ChrX:9437254-9437267 (-)	50,505 bp
Tssr162887	ChrX:9437201-9437213 (-)	50,559 bp
Tssr162886	ChrX:9437174-9437175 (-)	50,591 bp
Tssr162885	ChrX:9437127-9437155 (-)	50,625 bp
Tssr162884	ChrX:9437083-9437119 (-)	50,665 bp
Tssr162883	ChrX:9437041-9437054 (-)	50,718 bp
Tssr162882	ChrX:9436661-9436664 (-)	51,103 bp
Tssr162881	ChrX:9436350-9436364 (-)	51,409 bp
Tssr162880	ChrX:9436314-9436346 (-)	51,436 bp
Tssr162879	ChrX:9436248-9436260 (-)	51,512 bp
Tssr162878	ChrX:9436139-9436154 (-)	51,619 bp
Tssr162877	ChrX:9436087-9436102 (-)	51,671 bp
Tssr162876	ChrX:9436066-9436083 (-)	51,691 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16