Cybb
Gene Detail

Symbol Name ID

Cybb cytochrome b-245, beta polypeptide MGI:88574

Synonyms

Cgd, gp91phox, gp91, Nox2

Feature Type

protein coding gene

Genetic Map

Chromosome X

4.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

ChrX:9435252-9487771 bp, - strand From VEGA annotation of GRCm38   52520 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cybb

Human homologs

Human Homolog		CYBB, cytochrome b-245, beta polypeptide
NCBI Gene ID		1536
neXtProt AC		NX_P04839
Human Synonyms		AMCBX2, CGD, GP91-1, GP91PHOX, GP91-PHOX, NOX2, p91-PHOX
Human Chr (Location)		Xp21.1; chrX:37639270-37672714 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CYBB

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses.

 
Human Diseases Modeled Using Mouse Cybb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	electron transport chain, hydrogen peroxide biosynthetic process, ...
Component	cytoplasm, dendrite, ...
Function	electron carrier activity, flavin adenine dinucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (148)    Tissues (66)    Images (26)
Theiler Stages: 8, 9, 12, 13, 14, 16, 17, 19, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	24
Northern blot	6
RT-PCR	110

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016894 (Evidence)
Ensembl Gene Model	ENSMUSG00000015340 (Evidence)
Entrez Gene	13058 (Evidence)
DFCI	TC1574823, TC1599555, TC1746473
DoTS	DT.101165428, DT.101379403, DT.534026
NIA Mouse Gene Index	U039255
EC	1.-.-.-
Consensus CDS Project	CCDS30010.1
International Mouse Knockout Project Status	Cybb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016894	VEGA Gene Model | MGI Sequence Detail	52520	C57BL/6J
transcript	OTTMUST00000040996	VEGA | MGI Sequence Detail	4752	Not Applicable
polypeptide	OTTMUSP00000018354	VEGA | MGI Sequence Detail	570	Not Applicable

All sequences(63) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(3) : SNPs(176 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000778	Cytochrome b245, heavy chain
InterPro	IPR013112	FAD-binding 8
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR013121	Ferric reductase, NAD binding
InterPro	IPR013130	Ferric reductase transmembrane component-like domain
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000006087	cytochrome b-245 heavy chain

References

(Earliest) J:9438 Ryder-Cook AS, et al., Localization of the mdx mutation within the mouse dystrophin gene. EMBO J. 1988 Oct;7(10):3017-21
(Latest) J:195271 Qin L, et al., NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. 2013 Jun;61(6):855-68
All references(332)

Other accession IDs

MGD-MRK-1965, MGD-MRK-2263, MGI:2148082