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Ckm
Gene Detail
 Symbol
Name
ID
Ckm
creatine kinase, muscle
MGI:88413
STS D7Nds6
Synonyms Ckmm, MCK, M-CK
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr7:19411094-19421583 bp, + strand
From NCBI annotation of GRCm38

  10490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: creatine kinase
Gene Tree: Ckm

Human
homologs
Human Homolog CKM, creatine kinase, muscle
NCBI Gene ID 1158
neXtProt AC  NX_P06732
Human Synonyms  CKMM, M-CK
Human Chr (Location)  19q13.32; chr19:45306413-45323044 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.
 
Interactions
Ckm interacts with 23 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphocreatine biosynthetic process, phosphocreatine metabolic process, ...
Component cytoplasm
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (342)    Tissues (151)    Images (34)
Theiler Stages: 18, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 288
Northern blot 11
RT-PCR 36
RNase protection 7
cDNA source data(164)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(177) Genomic(3) cDNA(168) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030399 (Evidence)
Entrez Gene12715 (Evidence)
UniGene2375
DFCITC1574631, TC1724311
NIA Mouse Gene IndexU007765
EC2.7.3.2
Consensus CDS ProjectCCDS20902.1
International Mouse Knockout Project StatusCkm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12715 NCBI Gene Model | MGI Sequence Detail 10490 C57BL/6J ±  kb
transcript NM_007710 RefSeq | MGI Sequence Detail 1415 C57BL/6 
polypeptide P07310 UniProt | EBI | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(9) : PCR(4) RFLP(5) SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022415 ATP:guanido phosphotransferase active site
InterPro IPR022414 ATP:guanido phosphotransferase, catalytic domain
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology PR:000005515 creatine kinase M-type
Graphical View of Protein Domain Structure
References (Earliest) J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
(Latest) J:203690 Martinez-Lopez N, et al., Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
All references(115)
Other
accession IDs
MGD-MRK-2003

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory