Ckm
Gene Detail

Symbol Name ID

Ckm creatine kinase, muscle MGI:88413

STS

D7Nds6

Synonyms

Ckmm, MCK, M-CK

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr7:19411094-19421583 bp, + strand From NCBI annotation of GRCm38   10490 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: creatine kinase
Gene Tree: Ckm

Human homologs

Human Homolog		CKM, creatine kinase, muscle
NCBI Gene ID		1158
neXtProt AC		NX_P06732
Human Synonyms		CKMM, M-CK
Human Chr (Location)		19q13.32; chr19:45809671-45826235 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	phosphocreatine biosynthetic process, phosphocreatine metabolic process, ...
Component	cytoplasm
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (342)    Tissues (151)    Images (34)
Theiler Stages: 18, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	288
Northern blot	11
RT-PCR	36
RNase protection	7

cDNA source data(163)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(176) Genomic(3) cDNA(167) Primer pair(5) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030399 (Evidence)
Entrez Gene	12715 (Evidence)
UniGene	2375
DFCI	TC1574631, TC1724311
NIA Mouse Gene Index	U007765
EC	2.7.3.2
Consensus CDS Project	CCDS20902.1
International Mouse Knockout Project Status	Ckm

Sequences

Length	Strain/Species
genomic	12715	NCBI Gene Model | MGI Sequence Detail	10490	C57BL/6J
transcript	NM_007710	RefSeq | MGI Sequence Detail	1415	C57BL/6
polypeptide	P07310	UniProt | EBI | MGI Sequence Detail	381	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(9) : PCR(4) RFLP(5) SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000749	ATP:guanido phosphotransferase
InterPro	IPR022415	ATP:guanido phosphotransferase active site
InterPro	IPR022414	ATP:guanido phosphotransferase, catalytic domain
InterPro	IPR022413	ATP:guanido phosphotransferase, N-terminal
InterPro	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology	PR:000005515	creatine kinase M-type

Graphical View of Protein Domain Structure

References

(Earliest) J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
(Latest) J:187969 Pazin DE, et al., Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
All references(114)

Other accession IDs

MGD-MRK-2003