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Ckm Gene Detail
Summary
  • Symbol
    Ckm
  • Name
    creatine kinase, muscle
  • Synonyms
    Ckmm, MCK, M-CK
  • Feature Type
    protein coding gene
  • IDs
    MGI:88413
    NCBI Gene: 12715
Location & Maps
more
  • Sequence Map
    Chr7:19411094-19421583 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10490 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CKM, creatine kinase, muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CKM, creatine kinase, muscle
    Orthology source: HomoloGene
  • Synonyms
    CKMM, M-CK
  • Links
    NCBI Gene ID: 1158
    neXtProt AC: NX_P06732

  • Chr Location
    19q13.32; chr19:45306413-45322977 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    10 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12715 NCBI Gene Model | MGI Sequence Detail 10490 C57BL/6J ±  kb
transcript NM_007710 RefSeq | MGI Sequence Detail 1415 C57BL/6  
polypeptide P07310 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    125 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005515 creatine kinase M-type
  • EC
  • InterPro Domains
    IPR000749 ATP:guanido phosphotransferase
    IPR022415 ATP:guanido phosphotransferase active site
    IPR022414 ATP:guanido phosphotransferase, catalytic domain
    IPR022413 ATP:guanido phosphotransferase, N-terminal
    IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Molecular
Reagents
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  • All nucleic 177
    Genomic 3
    cDNA 168
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-2003
References
more
  • Summaries
    All 110
    Developmental Gene Expression 28
    Gene Ontology 8
    Phenotypes 36
  • Earliest
    J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
  • Latest
    J:203690 Martinez-Lopez N, et al., Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory