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Ckm Gene Detail
Summary
  • Symbol
    Ckm
  • Name
    creatine kinase, muscle
  • Synonyms
    Ckmm, MCK, M-CK
  • Feature Type
    protein coding gene
  • IDs
    MGI:88413
    NCBI Gene: 12715
  • Gene Overview
    MyGene.info: CKM
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19411094-19421583 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.67 cM
  • Mapping Data
    26 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88413
protein coding gene Chr7:19404776-19422841 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031776
protein coding gene Chr7:17410449-17420972 (+)
A/J MGP_AJ_G0031752
protein coding gene Chr7:17057072-17067376 (+)
AKR/J MGP_AKRJ_G0031678
protein coding gene Chr7:17529530-17539694 (+)
BALB/cJ MGP_BALBcJ_G0031757
protein coding gene Chr7:17258140-17268543 (+)
C3H/HeJ MGP_C3HHeJ_G0031479
protein coding gene Chr7:17788855-17800299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032223
protein coding gene Chr7:18285978-18296290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029289
protein coding gene Chr7:18702580-18713159 (+)
CAST/EiJ MGP_CASTEiJ_G0030822
protein coding gene Chr7:14200364-14221287 (+)
CBA/J MGP_CBAJ_G0031441
protein coding gene Chr7:18944105-18954627 (+)
DBA/2J MGP_DBA2J_G0031596
protein coding gene Chr7:16998927-17009691 (+)
FVB/NJ MGP_FVBNJ_G0031548
protein coding gene Chr7:16860962-16871264 (+)
LP/J MGP_LPJ_G0031679
protein coding gene Chr7:17733722-17744249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031584
protein coding gene Chr7:18802025-18812535 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032251
protein coding gene Chr7:17127153-17137308 (+)
PWK/PhJ MGP_PWKPhJ_G0030546
protein coding gene Chr7:14092591-14103469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030373
protein coding gene Chr7:11837761-11850306 (+)
WSB/EiJ MGP_WSBEiJ_G0030922
protein coding gene Chr7:17351608-17363401 (+)



Homology
more
  • Human Ortholog
    CKM, creatine kinase, M-type
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CKM, creatine kinase, M-type
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CKMM, CPK-M, M-CK
  • Links
    NCBI Gene ID: 1158
    neXtProt AC: NX_P06732
    UniProt: P06732

  • Chr Location
    19q13.32; chr19:45306413-45322977 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    10 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12715 NCBI Gene Model | MGI Sequence Detail 10490 C57BL/6J ±  kb
    transcript NM_007710 RefSeq | MGI Sequence Detail 1415 C57BL/6  
    polypeptide P07310 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005515 creatine kinase M-type
    • EC
    • InterPro Domains
      IPR000749 ATP:guanido phosphotransferase
      IPR022415 ATP:guanido phosphotransferase active site
      IPR022414 ATP:guanido phosphotransferase, catalytic domain
      IPR022413 ATP:guanido phosphotransferase, N-terminal
      IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 3
      cDNA 169
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2003
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 31
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
    • Latest
      J:257501 Dykes IM, et al., HIC2 regulates isoform switching during maturation of the cardiovascular system. J Mol Cell Cardiol. 2018 Jan;114:29-37

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory