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Cenpa
Gene Detail
Symbol

Name
ID
Cenpa
centromere protein A
MGI:88375
Synonyms
Cenp-A, centrosomin A
Feature Type
protein coding gene
Genetic Map
Chromosome 5
16.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:30666777-30674827 bp, + strand
From VEGA annotation of GRCm38

  8051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CENPA
Protein SuperFamily: histone H3
Gene Tree: Cenpa

Human
homologs
CENPA, centromere protein A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1058
neXtProt AC: NX_P49450

Human Synonyms: CenH3, CENP-A

Human Chr (Location): 2p23.3; chr2:26786014-26794589 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Radiation induced(3) Targeted(5)
Genomic Mutations involving Cenpa (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E10.5. Embryogenesis is impaired due to chromosomal missegregation, aneuploidy, and apoptosis.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Cenpa interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process establishment of mitotic spindle orientation, kinetochore assembly, ...
Component chromosome, chromosome, centromeric region, ...
Function DNA binding, protein heterodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(129)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cenpa    NEW 
Molecular
reagents
All nucleic(131) Genomic(2) cDNA(129)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022264 (Evidence)
Ensembl Gene Model ENSMUSG00000029177 (Evidence)
Entrez Gene 12615 (Evidence)
UniGene 290563
DFCI TC1572956, TC1599554, TC1631490, TC1714523, TC1725177, TC1766872
DoTS DT.110689853, DT.535717, DT.94167840, DT.94168464, DT.99861151
NIA Mouse Gene Index U005423
Consensus CDS Project CCDS19162.1
International Mouse Phenotyping Consortium Status Cenpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022264 VEGA Gene Model | MGI Sequence Detail 8051 C57BL/6J ±  kb
transcript OTTMUST00000053011 VEGA | MGI Sequence Detail 1354 Not Applicable 
polypeptide OTTMUSP00000025185 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(13) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007125 Histone core
InterPro IPR009072 Histone-fold
InterPro IPR000164 Histone H3
Protein Ontology PR:000005323 histone H3-like centromeric protein A
References
(Earliest) J:30521 Clarke L, et al., The structure and function of yeast centromeres. Annu Rev Genet. 1985;19:29-55
(Latest) J:217689 Guzman-Ayala M, et al., Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27
All references(42)
Other
accession IDs
MGD-MRK-1939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory