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Cenpa Gene Detail
Summary
  • Symbol
    Cenpa
  • Name
    centromere protein A
  • Synonyms
    Cenp-A, centrosomin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:88375
    NCBI Gene: 12615
Location & Maps
more
  • Sequence Map
    Chr5:30666777-30674830 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8054 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CENPA, centromere protein A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CENPA, centromere protein A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CenH3, CENP-A
  • Links
    NCBI Gene ID: 1058
    neXtProt AC: NX_P49450

  • Chr Location
    2p23.3; chr2:26786014-26794589 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    6 involving Cenpa
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E10.5. Embryogenesis is impaired due to chromosomal missegregation, aneuploidy, and apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022264 VEGA Gene Model | MGI Sequence Detail 8054 C57BL/6J ±  kb
transcript OTTMUST00000053011 VEGA | MGI Sequence Detail 1466 Not Applicable  
polypeptide OTTMUSP00000025185 VEGA | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    40 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 131
    Genomic 2
    cDNA 129

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1939
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:30521 Clarke L, et al., The structure and function of yeast centromeres. Annu Rev Genet. 1985;19:29-55
  • Latest
    J:217689 Guzman-Ayala M, et al., Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory