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Cenpa Gene Detail
Summary
  • Symbol
    Cenpa
  • Name
    centromere protein A
  • Synonyms
    Cenp-A, centrosomin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:88375
    NCBI Gene: 12615
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30824214-30832181 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88375
 protein coding gene Chr5:30824121-30832181 (+)
129S1/SvImJ ENSMUSG00200012950
 protein coding gene Chr5:26324262-26331805 (+)
A/J ENSMUSG00195042682
 protein coding gene Chr5:25772386-25780439 (+)
AKR/J ENSMUSG00220008898
 protein coding gene Chr5:25785435-25792978 (+)
BALB/cJ ENSMUSG00180028883
 protein coding gene Chr5:25576982-25585035 (+)
C3H/HeJ ENSMUSG00175041721
 protein coding gene Chr5:27551327-27559380 (+)
C57BL/6NJ ENSMUSG00215035925
 protein coding gene Chr5:26286992-26295045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027062
 protein coding gene Chr5:25173883-25181999 (+)
CAST/EiJ ENSTCUGG00005054139
 protein coding gene Chr5:25764255-25767071 (+)
CBA/J ENSMUSG00210043567
 protein coding gene Chr5:26524500-26532553 (+)
DBA/2J ENSMUSG00185037318
 protein coding gene Chr5:28378255-28386308 (+)
FVB/NJ ENSMUSG00205032552
 protein coding gene Chr5:25275919-25283972 (+)
JF1/MsJ ENSUMUG00000045067
 protein coding gene Chr5:32924533-32932512 (+)
LP/J ENSMUSG00230047860
 protein coding gene Chr5:32994749-33002463 (+)
NOD/ShiLtJ ENSMUSG00190013907
 protein coding gene Chr5:25575327-25583380 (+)
NZO/HlLtJ ENSMUSG00225015972
 protein coding gene Chr5:38202795-38210848 (+)
PWK/PhJ ENSLUMG00010044160
 protein coding gene Chr5:25675024-25682987 (+)
SPRET/EiJ ENSMSPG00010038618
 protein coding gene Chr5:26795940-26802956 (+)
WSB/EiJ ENSIUOG00005039484
 protein coding gene Chr5:28474637-28482528 (+)



Homology
more
  • Human Ortholog
    CENPA, centromere protein A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPA, centromere protein A
  • Synonyms
    CenH3, CENP-A
  • Links
    NCBI Gene ID: 1058
    UniProt: P49450

  • Chr Location
    2p23.3; chr2:26764289-26801067 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CENPA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E10.5. Embryogenesis is impaired due to chromosomal missegregation, aneuploidy, and apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    7
  • cDNA Data
    130
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12615 NCBI Gene Model | MGI Sequence Detail 7968 C57BL/6J ±  kb
    transcript NR_185303 RefSeq | MGI Sequence Detail 1613 ZRU/MplStud  
    polypeptide O35216 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 2
      cDNA 130
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1939
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:382969 Huang TC, et al., Global reorganization of genome architecture at the transition to gametogenesis. Nat Struct Mol Biol. 2026 Mar;33(3):433-447
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory