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Cenpa Gene Detail
Summary
  • Symbol
    Cenpa
  • Name
    centromere protein A
  • Synonyms
    Cenp-A, centrosomin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:88375
    NCBI Gene: 12615
  • Gene Overview
    MyGene.info: CENPA
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30666886-30674837 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88375
protein coding gene Chr5:30666777-30674837 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029394
protein coding gene Chr5:28624662-28632120 (+)
A/J MGP_AJ_G0029360
protein coding gene Chr5:27683977-27692030 (+)
AKR/J MGP_AKRJ_G0029311
protein coding gene Chr5:28835195-28842738 (+)
BALB/cJ MGP_BALBcJ_G0029371
protein coding gene Chr5:28210949-28218917 (+)
C3H/HeJ MGP_C3HHeJ_G0029092
protein coding gene Chr5:28829170-28837150 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029824
protein coding gene Chr5:30365516-30375093 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027062
protein coding gene Chr5:25173883-25181999 (+)
CAST/EiJ MGP_CASTEiJ_G0028503
protein coding gene Chr5:27929465-27936688 (+)
CBA/J MGP_CBAJ_G0029060
protein coding gene Chr5:30958359-30967062 (+)
DBA/2J MGP_DBA2J_G0029209
protein coding gene Chr5:27872816-27880869 (+)
FVB/NJ MGP_FVBNJ_G0029167
protein coding gene Chr5:27283537-27291701 (+)
LP/J MGP_LPJ_G0029294
protein coding gene Chr5:29077283-29084784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029196
protein coding gene Chr5:31854782-31862750 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029858
protein coding gene Chr5:28335535-28343475 (+)
PWK/PhJ MGP_PWKPhJ_G0028227
protein coding gene Chr5:26987477-26995388 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028058
protein coding gene Chr5:27685508-27693306 (+)
WSB/EiJ MGP_WSBEiJ_G0028583
protein coding gene Chr5:28406657-28414548 (+)



Homology
more
  • Human Ortholog
    CENPA, centromere protein A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CENPA, centromere protein A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CenH3, CENP-A
  • Links
    NCBI Gene ID: 1058
    neXtProt AC: NX_P49450
    UniProt: P49450

  • Chr Location
    2p23.3; chr2:26786014-26794589 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E10.5. Embryogenesis is impaired due to chromosomal missegregation, aneuploidy, and apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12615 NCBI Gene Model | MGI Sequence Detail 7952 C57BL/6J ±  kb
    transcript NM_001302131 RefSeq | MGI Sequence Detail 1555 C57BL/6  
    polypeptide O35216 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 2
      cDNA 129

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1939
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:242348 Soh YQS, et al., Meioc maintains an extended meiotic prophase I in mice. PLoS Genet. 2017 Apr;13(4):e1006704

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory