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Cdk11b Gene Detail
Summary
  • Symbol
    Cdk11b
  • Name
    cyclin-dependent kinase 11B
  • Synonyms
    Cdc2l1, Cdc2l2, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE proteins
  • Feature Type
    protein coding gene
  • IDs
    MGI:88353
    NCBI Gene: 12537
  • Gene Overview
    MyGene.info: CDK11B
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155624852-155649935 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 86.73 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88353
protein coding gene Chr4:155624852-155649938 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029219
protein coding gene Chr4:159970703-159999328 (+)
A/J MGP_AJ_G0029184
protein coding gene Chr4:153246073-153271728 (+)
AKR/J MGP_AKRJ_G0029132
protein coding gene Chr4:157410497-157437657 (+)
BALB/cJ MGP_BALBcJ_G0029200
protein coding gene Chr4:153718269-153742976 (+)
C3H/HeJ MGP_C3HHeJ_G0028921
protein coding gene Chr4:157958240-157983313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029649
protein coding gene Chr4:165654825-165681836 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026894
protein coding gene Chr4:145538622-145561097 (+)
CAST/EiJ MGP_CASTEiJ_G0028333
protein coding gene Chr4:155408379-155439065 (+)
CBA/J MGP_CBAJ_G0028883
protein coding gene Chr4:170661886-170686587 (+)
DBA/2J MGP_DBA2J_G0029032
protein coding gene Chr4:153266385-153291427 (+)
FVB/NJ MGP_FVBNJ_G0028995
protein coding gene Chr4:152505869-152531190 (+)
LP/J MGP_LPJ_G0029122
protein coding gene Chr4:159890965-159916397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029022
protein coding gene Chr4:173468785-173499113 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029681
protein coding gene Chr4:158034897-158064417 (+)
PWK/PhJ MGP_PWKPhJ_G0028054
protein coding gene Chr4:149404268-149431713 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027888
protein coding gene Chr4:152297304-152323188 (+)
WSB/EiJ MGP_WSBEiJ_G0028413
protein coding gene Chr4:158209789-158234775 (+)



Homology
more
  • Human Ortholog
    CDK11A, cyclin dependent kinase 11A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDK11A, cyclin dependent kinase 11A
    Orthology source: HomoloGene
  • Synonyms
    CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE
  • Links
    NCBI Gene ID: 728642
    neXtProt AC: NX_Q9UQ88
    UniProt: Q9UQ88

  • Chr Location
    1p36.33; chr1:1702383-1724565 (-)  GRCh38.p7

  • Human Ortholog
    CDK11B, cyclin dependent kinase 11B
    Orthology source: HGNC
  • Synonyms
    CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, p58, p58CDC2L1, p58CLK-1, PITSLREA, PK58
  • Links
    NCBI Gene ID: 984
    neXtProt AC: NX_P21127
    UniProt: P21127

  • Chr Location
    1p36.33; chr1:1635226-1659839 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos display embryonic lethality from cell cycle arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12537 NCBI Gene Model | MGI Sequence Detail 25084 C57BL/6J ±  kb
    transcript NM_001355569 RefSeq | MGI Sequence Detail 2999 C57BL/6  
    polypeptide P24788 UniProt | EBI | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 106

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1880, MGI:1098660, MGI:2140185
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:17392 Eipers PG, et al., Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15. Genomics. 1991 Nov;11(3):621-9
    • Latest
      J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory