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Cdk11b
Gene Detail
Symbol

Name
ID
Cdk11b
cyclin-dependent kinase 11B
MGI:88353
Synonyms
Cdc2l1, Cdc2l2, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE proteins
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:155624854-155649938 bp, + strand
From VEGA annotation of GRCm38

  25085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK11A
Gene Tree: Cdk11b

Human
homologs
CDK11A, cyclin-dependent kinase 11A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 728642
neXtProt AC: NX_Q9UQ88

Human Synonyms: CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE

Human Chr (Location): 1p36.33; chr1:1702730-1724352 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null embryos display embryonic lethality from cell cycle arrest.
 
Interactions
Cdk11b interacts with 41 markers (Mir10a, Mir18, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blastocyst development, cell cycle, ...
Component cytoplasm, nucleoplasm, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (142)    Tissues (119)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 128
Northern blot 13
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk11b    NEW 
Molecular
reagents
All nucleic(105) cDNA(105)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010724 (Evidence)
Ensembl Gene Model ENSMUSG00000029062 (Evidence)
Entrez Gene 12537 (Evidence)
UniGene 267410
DFCI TC1575475
DoTS DT.101404092, DT.101404096, DT.87068952, DT.91303912, DT.94304876, DT.94341562
NIA Mouse Gene Index U005211
EC 2.7.11.22
Consensus CDS Project CCDS19033.1
International Mouse Phenotyping Consortium Status Cdk11b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010724 VEGA Gene Model | MGI Sequence Detail 25085 C57BL/6J ±  kb
transcript OTTMUST00000025022 VEGA | MGI Sequence Detail 2595 Not Applicable 
polypeptide OTTMUSP00000011463 VEGA | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(26) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005196 cyclin-dependent kinase 11B
References
(Earliest) J:17392 Eipers PG, et al., Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15. Genomics. 1991 Nov;11(3):621-9
(Latest) J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
All references(47)
Other
accession IDs
MGD-MRK-1880, MGI:1098660, MGI:2140185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory