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Car2
Gene Detail
 Symbol
Name
ID
Car2
carbonic anhydrase 2
MGI:88269
Synonyms CAII, CA II, Car-2, Ltw-5, Lvtw-5
Feature Type protein coding gene
Genetic Map
Chromosome 3
3.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(42)
Sequence Map
Chr3:14886426-14900769 bp, + strand
From Ensembl annotation of GRCm38

  14344 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car2

Human
homologs
Human Homolog CA2, carbonic anhydrase II
NCBI Gene ID 760
neXtProt AC  NX_P00918
Human Synonyms  CAC, CAII, CA-II, Car2, HEL-76
Human Chr (Location)  8q22; chr8:85463902-85481492 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CA2
Alleles
and
phenotypes
All alleles(2) : Targeted(1) Chemically induced(1)
 
Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.
 
Human Diseases Modeled Using Mouse Car2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiotensin-activated signaling pathway, carbon dioxide transport, ...
Component apical part of cell, axon, ...
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (315)    Tissues (183)    Images (70)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 310
RT-PCR 3
cDNA source data(241)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(251) Genomic(5) cDNA(242) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027562 (Evidence)
Entrez Gene12349 (Evidence)
UniGene1186
DFCITC1573115, TC1631378
DoTSDT.101405047, DT.536972, DT.94218800
NIA Mouse Gene IndexU003042
EC4.2.1.1
Consensus CDS ProjectCCDS17251.1
International Mouse Knockout Project StatusCar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027562 Ensembl Gene Model | MGI Sequence Detail 14344 C57BL/6J ±  kb
transcript ENSMUST00000029078 Ensembl | MGI Sequence Detail 1789 Not Applicable 
polypeptide ENSMUSP00000029078 Ensembl | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018443 Carbonic anhydrase, CA-XIII
Protein Ontology PR:000004918 carbonic anhydrase 2
References (Earliest) J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
(Latest) J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
All references(123)
Other
accession IDs
MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory