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Car2
Gene Detail
Symbol

Name
ID
Car2
carbonic anhydrase 2
MGI:88269
Synonyms
CAII, CA II, Car-2, Ltw-5, Lvtw-5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(42)
Sequence Map
Chr3:14886273-14900770 bp, + strand
From VEGA annotation of GRCm38

  14498 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CA2
Protein SuperFamily: carbonate dehydratase
Gene Tree: Car2

Human
homologs
CA2, carbonic anhydrase II
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 760
neXtProt AC: NX_P00918

Human Synonyms: CAC, CAII, CA-II, Car2, HEL-76

Human Chr (Location): 8q22; chr8:85463902-85481492 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Chemically induced (ENU)(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.
 
Human Diseases Modeled in Mice Using Car2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Car2 interacts with 133 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process angiotensin-activated signaling pathway, carbon dioxide transport, ...
Component apical part of cell, axon, ...
Function arylesterase activity, carbonate dehydratase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (357)    Tissues (209)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 310
RT-PCR 3
cDNA source data(241)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CA2 ; Xenbase ca2 ; ZFIN cahz    NEW 
Molecular
reagents
All nucleic(251) Genomic(5) cDNA(242) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051087 (Evidence)
Ensembl Gene Model ENSMUSG00000027562 (Evidence)
Entrez Gene 12349 (Evidence)
UniGene 1186
DFCI TC1573115, TC1631378
DoTS DT.101405047, DT.536972, DT.94218800
NIA Mouse Gene Index U003042
EC 4.2.1.1
Consensus CDS Project CCDS17251.1
International Mouse Phenotyping Consortium Status Car2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051087 VEGA Gene Model | MGI Sequence Detail 14498 C57BL/6J ±  kb
transcript OTTMUST00000129484 VEGA | MGI Sequence Detail 1788 Not Applicable 
polypeptide OTTMUSP00000069538 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018443 Carbonic anhydrase, CA-XIII
Protein Ontology PR:000004918 carbonic anhydrase 2
References
(Earliest) J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
(Latest) J:216175 Cerqueira DM, et al., Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. Dev Biol. 2014 Oct 1;394(1):54-64
All references(128)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory