Car2
Gene Detail

Symbol

Name
ID

Car2
carbonic anhydrase 2
MGI:88269

Synonyms

CAII, CA II, Car-2, Ltw-5, Lvtw-5

Feature Type

protein coding gene

Genetic Map

Chromosome 3
3.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(42)

Sequence Map

Chr3:14886273-14900770 bp, + strand From VEGA annotation of GRCm38   14498 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car2

Human
homologs

Human Homolog		CA2, carbonic anhydrase II
NCBI Gene ID		760
neXtProt AC		NX_P00918
Human Synonyms		CAC, CAII, CA-II, Car2, HEL-76
Human Chr (Location)		8q22; chr8:85463902-85481492 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human CA2

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Chemically induced (ENU)(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.

 
Human Diseases Modeled in Mice Using Car2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)

Interactions

Car2 interacts with 133 markers (Mir15a, Mir19b-1, Mir19b-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (36 annotations)

Process	angiotensin-activated signaling pathway, carbon dioxide transport, ...
Component	apical part of cell, axon, ...
Function	carbonate dehydratase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)

Data Summary: Results (315)    Tissues (184)    Images (70)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	2
RNA in situ	310
RT-PCR	3

cDNA source data(241)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(251) Genomic(5) cDNA(242) Primer pair(3) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000051087 (Evidence)
Ensembl Gene Model	ENSMUSG00000027562 (Evidence)
Entrez Gene	12349 (Evidence)
UniGene	1186
DFCI	TC1573115, TC1631378
DoTS	DT.101405047, DT.536972, DT.94218800
NIA Mouse Gene Index	U003042
EC	4.2.1.1
Consensus CDS Project	CCDS17251.1
International Mouse Knockout Project Status	Car2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000051087	VEGA Gene Model | MGI Sequence Detail	14498	C57BL/6J
transcript	OTTMUST00000129484	VEGA | MGI Sequence Detail	1788	Not Applicable
polypeptide	OTTMUSP00000069538	VEGA | MGI Sequence Detail	260	Not Applicable

All sequences(60) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(3) : SNPs within 2kb(182 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR023561	Carbonic anhydrase, alpha-class
InterPro	IPR018338	Carbonic anhydrase, alpha-class, conserved site
InterPro	IPR018443	Carbonic anhydrase, CA-XIII
Protein Ontology	PR:000004918	carbonic anhydrase 2

References

(Earliest) J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
(Latest) J:216175 Cerqueira DM, et al., Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. Dev Biol. 2014 Oct 1;394(1):54-64
All references(131)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632