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Car2 Gene Detail
Summary
  • Symbol
    Car2
  • Name
    carbonic anhydrase 2
  • Synonyms
    CAII, CA II, Car-2, Ltw-5, Lvtw-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88269
    NCBI Gene: 12349
  • Gene Overview
    MyGene.info: CA2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr3:14886273-14900770 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14498 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.23 cM
  • Mapping Data
    43 experiments
Homology
more
  • Human Ortholog
    CA2, carbonic anhydrase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CA2, carbonic anhydrase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAC, CAII, CA-II, Car2, HEL-76, HEL-S-282
  • Links
    NCBI Gene ID: 760
    neXtProt AC: NX_P00918
    UniProt: P00918

  • Chr Location
    8q21.2; chr8:85463902-85481492 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Car2 mouse models; 1 with human CA2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    364
  • Tissues
    214
  • cDNA Data
    242
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051087 VEGA Gene Model | MGI Sequence Detail 14498 C57BL/6J ±  kb
    transcript OTTMUST00000129484 VEGA | MGI Sequence Detail 1788 Not Applicable  
    polypeptide OTTMUSP00000069538 VEGA | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      178 from dbSNP Build 142
    • RFLP
      3
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 252
      Genomic 5
      cDNA 243
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 31
      Diseases 2
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
    • Latest
      J:249938 Werth M, et al., Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017 Jun 3;6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory