Car2
Gene Detail

Symbol Name ID

Car2 carbonic anhydrase 2 MGI:88269

Synonyms

CAII, CA II, Car-2, Ltw-5, Lvtw-5

Feature Type

protein coding gene

Genetic Map

Chromosome 3

3.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(42)

Sequence Map

Chr3:14886426-14900769 bp, + strand From Ensembl annotation of GRCm38   14344 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car2

Human homologs

Human Homolog		CA2, carbonic anhydrase II
NCBI Gene ID		760
neXtProt AC		NX_P00918
Human Synonyms		CAC, CAII, CA-II, Car2, HEL-76
Human Chr (Location)		8q22; chr8:86376131-86393721 (+)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human CA2

Alleles and phenotypes

All alleles(2) : Targeted(1) Chemically induced(1)
 

Homozygous mutant mice are growth retarded, display renal tubular acidosis, but mutants have not been recovered that display osteopetrosis as found in human CA-II deficiency.

 
Human Diseases Modeled Using Mouse Car2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	angiotensin-activated signaling pathway, carbon dioxide transport, ...
Component	apical part of cell, axon, ...
Function	carbonate dehydratase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)

Data Summary: Results (315)    Tissues (183)    Images (70)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	310
RT-PCR	3

cDNA source data(241)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(251) Genomic(5) cDNA(242) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027562 (Evidence)
Entrez Gene	12349 (Evidence)
UniGene	1186
DFCI	TC1573115, TC1631378
DoTS	DT.101405047, DT.536972, DT.94218800
NIA Mouse Gene Index	U003042
EC	4.2.1.1
Consensus CDS Project	CCDS17251.1
International Mouse Knockout Project Status	Car2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000027562	Ensembl Gene Model | MGI Sequence Detail	14344	C57BL/6J
transcript	ENSMUST00000029078	Ensembl | MGI Sequence Detail	1789	Not Applicable
polypeptide	ENSMUSP00000029078	Ensembl | MGI Sequence Detail	260	Not Applicable

All sequences(50) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(3) : SNPs within 2kb(182 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR023561	Carbonic anhydrase, alpha-class
InterPro	IPR018338	Carbonic anhydrase, alpha-class, conserved site
InterPro	IPR018443	Carbonic anhydrase, CA-XIII
Protein Ontology	PR:000004918	carbonic anhydrase 2

References

(Earliest) J:5671 Davisson MT, et al., Genes on chromosome 3 of the mouse. J Hered. 1976 May-Jun;67(3):155-6
(Latest) J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
All references(122)

Other accession IDs

MGD-MRK-11922, MGD-MRK-11945, MGD-MRK-1760, MGD-MRK-1763, MGI:2139632