Camk2a MGI Mouse Gene Detail - MGI:88256 - calcium/calmodulin-dependent protein kinase II alpha

Camk2a Gene Detail

Symbol

Camk2a
Name

calcium/calmodulin-dependent protein kinase II alpha
Synonyms

alpha-CaMKII, mKIAA0968

Feature Type

protein coding gene
IDs

MGI:88256
NCBI Gene: 12322
Gene Overview

MyGene.info: CAMK2A

Sequence Map

Chr18:60925618-60988152 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

62535 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.41 cM
Mapping Data

5 experiments

Human Ortholog

CAMK2A, calcium/calmodulin dependent protein kinase II alpha

Vertebrate Orthologs

9

Human Ortholog

CAMK2A, calcium/calmodulin dependent protein kinase II alpha
Orthology source: HomoloGene, HGNC
Synonyms

CAMKA
Links

HGNC:1460

NCBI Gene ID: 815

neXtProt AC: NX_Q9UQM7
Chr Location

5q32; chr5:150219491-150289840 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 56577
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CAMK2A
Protein SuperFamily

calcium/calmodulin-dependent protein kinase II
Gene Tree

Camk2a

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Phenotype Summary

34 phenotypes from 9 alleles in 10 genetic backgrounds
14 phenotypes from multigenic genotypes
1 images
63 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Gene trapped

35
Targeted

14
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.

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All GO Annotations

52
GO References

21

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

450
Tissues

111
cDNA Data

11
Literature Summary

25

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase camk2a

ZFIN camk2a

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Camk2a interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

58
RefSeq

10
UniProt

6
CCDS

CCDS29276.1, CCDS29277.1, CCDS70898.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016302	VEGA Gene Model \| MGI Sequence Detail	62535	C57BL/6J	± kb
transcript	OTTMUST00000039176	VEGA \| MGI Sequence Detail	3244	Not Applicable
polypeptide	OTTMUSP00000017499	VEGA \| MGI Sequence Detail	489	Not Applicable

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SNPs within 2kb

420 from dbSNP Build 142

RFLP

2

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UniProt

6 Sequences
Protein Ontology

PR:000003199 calcium/calmodulin-dependent protein kinase type II subunit alpha
PDB

1HKX, 4X3I
EC

2.7.11.17
InterPro Domains

IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase

IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain

IPR032710 NTF2-like domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 16

Genomic 1

cDNA 13

Primer pair 2

Microarray probesets 7

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MGD-MRK-1743, MGI:2147420

Summaries

All 176

Developmental Gene Expression 25

Gene Ontology 21

Phenotypes 63
Earliest

J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
Latest

J:229890 Ang SY, et al., KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1;143(5):810-21

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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