Camk2a
Gene Detail

Symbol Name ID

Camk2a calcium/calmodulin-dependent protein kinase II alpha MGI:88256

Synonyms

alpha-CaMKII, CaMKII, mKIAA0968

Feature Type

protein coding gene

Genetic Map

Chromosome 18

34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr18:60925618-60988152 bp, + strand From VEGA annotation of GRCm38   62535 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
Gene Tree: Camk2a

Human homologs

Human Homolog		CAMK2A, calcium/calmodulin-dependent protein kinase II alpha
NCBI Gene ID		815
neXtProt AC		NX_Q9UQM7
Human Synonyms		CAMKA
Human Chr (Location)		5q32; chr5:149599054-149669403 (-)  GRCh37.p13

Alleles and phenotypes

All alleles(47) : Targeted(12) Gene trapped(35)
 

Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	calcium ion transport, G1/S transition of mitotic cell cycle, ...
Component	calcium- and calmodulin-dependent protein kinase complex, cell junction, ...
Function	ATP binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)

Data Summary: Results (450)    Tissues (111)    Images (68)
Theiler Stages: 1, 2, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	395
RT-PCR	50

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016302 (Evidence)
Ensembl Gene Model	ENSMUSG00000024617 (Evidence)
Entrez Gene	12322 (Evidence)
DFCI	TC1581606, TC1593090, TC1613551, TC1647899, TC1656617, TC1679395, TC1684806
DoTS	DT.101299628, DT.101333842, DT.101722748, DT.40167149, DT.55281964, DT.87036844, DT.91327836, DT.94326508
NIA Mouse Gene Index	U018785
EC	2.7.11.17
PDB	1HKX
Consensus CDS Project	CCDS29276.1, CCDS29277.1
International Mouse Knockout Project Status	Camk2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016302	VEGA Gene Model | MGI Sequence Detail	62535	C57BL/6J
transcript	OTTMUST00000039176	VEGA | MGI Sequence Detail	3244	Not Applicable
polypeptide	OTTMUSP00000017499	VEGA | MGI Sequence Detail	489	Not Applicable

All sequences(74) RefSeq(10) UniProt(6)

Polymorphisms

RFLP(2) : SNPs within 2kb(423 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR020636	Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003199	calcium/calmodulin-dependent protein kinase type II alpha chain

References

(Earliest) J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
(Latest) J:199094 Easton AC, et al., alphaCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice. Behav Brain Res. 2013 May 31;252C:72-76
All references(161)

Other accession IDs

MGD-MRK-1743, MGI:2147420