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Camk2a
Gene Detail
Symbol

Name
ID
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
MGI:88256
Synonyms
alpha-CaMKII, mKIAA0968
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr18:60925618-60988152 bp, + strand
From VEGA annotation of GRCm38

  62535 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CAMK2A
Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
Gene Tree: Camk2a

Human
homologs
CAMK2A, calcium/calmodulin-dependent protein kinase II alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 815
neXtProt AC: NX_Q9UQM7

Human Synonyms: CAMKA

Human Chr (Location): 5q32; chr5:150219491-150289840 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(35) Targeted(13) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.
 
Phenotype Images(1)
Interactions
Camk2a interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process angiotensin-activated signaling pathway, calcium ion transport, ...
Component axon, cell junction, ...
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (450)    Tissues (111)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 395
RT-PCR 50
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase camk2a ; ZFIN camk2a    NEW 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016302 (Evidence)
Ensembl Gene Model ENSMUSG00000024617 (Evidence)
Entrez Gene 12322 (Evidence)
DFCI TC1581606, TC1593090, TC1613551, TC1647899, TC1656617, TC1679395, TC1684806
DoTS DT.101299628, DT.101333842, DT.101722748, DT.40167149, DT.55281964, DT.87036844, DT.91327836, DT.94326508
NIA Mouse Gene Index U018785
EC 2.7.11.17
PDB 1HKX
Consensus CDS Project CCDS29276.1, CCDS29277.1, CCDS70898.1
International Mouse Phenotyping Consortium Status Camk2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016302 VEGA Gene Model | MGI Sequence Detail 62535 C57BL/6J ±  kb
transcript OTTMUST00000039176 VEGA | MGI Sequence Detail 3244 Not Applicable 
polypeptide OTTMUSP00000017499 VEGA | MGI Sequence Detail 489 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003199 calcium/calmodulin-dependent protein kinase type II subunit alpha
References
(Earliest) J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
(Latest) J:222910 Goh JJ, et al., Role of inhibitory autophosphorylation of calcium/calmodulin-dependent kinase II (alphaCAMKII) in persistent (>24 h) hippocampal LTP and in LTD facilitated by novel object-place learning and recognition in mice. Behav Brain Res. 2015 May 15;285:79-88
All references(170)
Other
accession IDs
MGD-MRK-1743, MGI:2147420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory