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Camk2a
Gene Detail
 Symbol
Name
ID
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
MGI:88256
Synonyms alpha-CaMKII, mKIAA0968
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr18:60925618-60988152 bp, + strand
From VEGA annotation of GRCm38

  62535 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
Gene Tree: Camk2a

Human
homologs
Human Homolog CAMK2A, calcium/calmodulin-dependent protein kinase II alpha
NCBI Gene ID 815
neXtProt AC  NX_Q9UQM7
Human Synonyms  CAMKA
Human Chr (Location)  5q32; chr5:150219491-150289840 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(35) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.
 
Interactions
Camk2a interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process calcium ion transport, G1/S transition of mitotic cell cycle, ...
Component calcium- and calmodulin-dependent protein kinase complex, cell junction, ...
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (450)    Tissues (111)    Images (68)
Theiler Stages: 1, 2, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 395
RT-PCR 50
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016302 (Evidence)
Ensembl Gene ModelENSMUSG00000024617 (Evidence)
Entrez Gene12322 (Evidence)
DFCITC1581606, TC1593090, TC1613551, TC1647899, TC1656617, TC1679395, TC1684806
DoTSDT.101299628, DT.101333842, DT.101722748, DT.40167149, DT.55281964, DT.87036844, DT.91327836, DT.94326508
NIA Mouse Gene IndexU018785
EC2.7.11.17
PDB1HKX
Consensus CDS ProjectCCDS29276.1, CCDS29277.1, CCDS70898.1
International Mouse Knockout Project StatusCamk2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016302 VEGA Gene Model | MGI Sequence Detail 62535 C57BL/6J ±  kb
transcript OTTMUST00000039176 VEGA | MGI Sequence Detail 3244 Not Applicable 
polypeptide OTTMUSP00000017499 VEGA | MGI Sequence Detail 489 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003199 calcium/calmodulin-dependent protein kinase type II subunit alpha
References (Earliest) J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
(Latest) J:211257 Kon N, et al., CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms. Genes Dev. 2014 May 15;28(10):1101-10
All references(165)
Other
accession IDs
MGD-MRK-1743, MGI:2147420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory