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Camk2a Gene Detail
Summary
  • Symbol
    Camk2a
  • Name
    calcium/calmodulin-dependent protein kinase II alpha
  • Synonyms
    alpha-CaMKII, mKIAA0968
  • Feature Type
    protein coding gene
  • IDs
    MGI:88256
    NCBI Gene: 12322
  • Gene Overview
    MyGene.info: CAMK2A
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:60925618-60988152 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      62535 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CAMK2A, calcium/calmodulin dependent protein kinase II alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CAMK2A, calcium/calmodulin dependent protein kinase II alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMKA, MRD53
  • Links
    NCBI Gene ID: 815
    neXtProt AC: NX_Q9UQM7
    UniProt: Q9UQM7

  • Chr Location
    5q32; chr5:150219491-150289840 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 10 alleles in 13 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    69
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    450
  • Tissues
    111
  • cDNA Data
    11
  • Literature Summary
    28
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016302 VEGA Gene Model | MGI Sequence Detail 62535 C57BL/6J ±  kb
transcript OTTMUST00000039176 VEGA | MGI Sequence Detail 3244 Not Applicable  
polypeptide OTTMUSP00000017499 VEGA | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    420 from dbSNP Build 142
  • RFLP
    2
Protein
Information
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  • UniProt
    6 Sequences
  • PDB
    1HKX, 4X3I
  • EC
    2.7.11.17
  • InterPro Domains
    IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
    IPR032710 NTF2-like domain superfamily
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 13
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-1743, MGI:2147420
References
more
  • Summaries
    All 237
    Developmental Gene Expression 28
    Gene Ontology 25
    Phenotypes 71
  • Earliest
    J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
  • Latest
    J:256424 Hu X, et al., CaMKIIalpha Mediates the Effect of IL-17 To Promote Ongoing Spontaneous and Evoked Pain in Multiple Sclerosis. J Neurosci. 2018 Jan 3;38(1):232-244
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory