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Camk2a Gene Detail
Summary
  • Symbol
    Camk2a
  • Name
    calcium/calmodulin-dependent protein kinase II alpha
  • Synonyms
    alpha-CaMKII, mKIAA0968
  • Feature Type
    protein coding gene
  • IDs
    MGI:88256
    NCBI Gene: 12322
  • Gene Overview
    MyGene.info: CAMK2A
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60925618-60988152 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88256
 protein coding gene Chr18:60925577-60988152 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024471
 protein coding gene Chr18:60773163-60843362 (+)
A/J MGP_AJ_G0024438
 protein coding gene Chr18:58169121-58233458 (+)
AKR/J MGP_AKRJ_G0024408
 protein coding gene Chr18:59770918-59839109 (+)
BALB/cJ MGP_BALBcJ_G0024437
 protein coding gene Chr18:58293837-58358881 (+)
C3H/HeJ MGP_C3HHeJ_G0024205
 protein coding gene Chr18:60001492-60065667 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024884
 protein coding gene Chr18:62429931-62495897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022315
 protein coding gene Chr18:57712772-57776733 (+)
CAST/EiJ MGP_CASTEiJ_G0023678
 protein coding gene Chr18:59865852-59934499 (+)
CBA/J MGP_CBAJ_G0024175
 protein coding gene Chr18:64439349-64501267 (+)
DBA/2J MGP_DBA2J_G0024305
 protein coding gene Chr18:57841389-57904298 (+)
FVB/NJ MGP_FVBNJ_G0024271
 protein coding gene Chr18:57245290-57311141 (+)
LP/J MGP_LPJ_G0024388
 protein coding gene Chr18:60622500-60691134 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024300
 protein coding gene Chr18:66068325-66132271 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024931
 protein coding gene Chr18:59963881-60031641 (+)
PWK/PhJ MGP_PWKPhJ_G0023421
 protein coding gene Chr18:58066388-58130161 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023227
 protein coding gene Chr18:60197976-60260747 (+)
WSB/EiJ MGP_WSBEiJ_G0023742
 protein coding gene Chr18:59820424-59887849 (+)



Homology
more
  • Human Ortholog
    CAMK2A, calcium/calmodulin dependent protein kinase II alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CAMK2A, calcium/calmodulin dependent protein kinase II alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMKA, CaMKIINalpha, MRD53, MRT63
  • Links
    NCBI Gene ID: 815
    neXtProt AC: NX_Q9UQM7
    UniProt: Q9UQM7

  • Chr Location
    5q32; chr5:150219491-150289840 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Camk2a mouse models; 1 with human CAMK2A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 11 alleles in 15 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    459
  • Tissues
    113
  • cDNA Data
    12
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024617 Ensembl Gene Model | MGI Sequence Detail 62535 C57BL/6J ±  kb
    transcript ENSMUST00000025519 Ensembl | MGI Sequence Detail 3244 Not Applicable  
    polypeptide ENSMUSP00000025519 Ensembl | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • PDB
      1HKX, 4X3I
    • EC
      2.7.11.17
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR039071 Calcium/calmodulin-dependent protein kinase type II
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1743, MGI:2147420
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 28
      Phenotypes 78
    • Earliest
      J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
    • Latest
      J:266891 Yamagata Y, et al., Differential Involvement of Kinase Activity of Ca(2+)/Calmodulin-Dependent Protein Kinase IIalpha in Hippocampus- and Amygdala-Dependent Memory Revealed by Kinase-Dead Knock-In Mouse. eNeuro. 2018 Jul-Aug;5(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/04/2018
    MGI 6.13     		The Jackson Laboratory