Anxa6
Gene Detail

Symbol Name ID

Anxa6 annexin A6 MGI:88255

Synonyms

Annexin VI, Anx6, AnxVI, Cabm, Camb

Feature Type

protein coding gene

Genetic Map

Chromosome 11

32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr11:54979108-55033445 bp, - strand From VEGA annotation of GRCm38   54338 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: annexin VI
Gene Tree: Anxa6

Human homologs

Human Homolog		ANXA6, annexin A6
NCBI Gene ID		309
neXtProt AC		NX_P08133
Human Synonyms		ANX6, CBP68
Human Chr (Location)		5q33.1; chr5:150480267-150537443 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(36) : Targeted(5) Gene trapped(31)
 

Mice homozygous for a knock-out allele have normal immunological development but exhibit altered cardiomyocyte mechanics and intracellular calcium signaling.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	calcium ion transport, regulation of muscle contraction
Component	apical plasma membrane, cytoplasm, ...
Function	calcium-dependent phospholipid binding, calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(285)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(289) Genomic(1) cDNA(288)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006325 (Evidence)
Ensembl Gene Model	ENSMUSG00000018340 (Evidence)
Entrez Gene	11749 (Evidence)
UniGene	265347
DFCI	TC1573117, TC1585077, TC1598026, TC1766609
DoTS	DT.101139178, DT.101392554, DT.101392560, DT.110502308, DT.55193012, DT.87072576, DT.91588093, DT.94411864
NIA Mouse Gene Index	U032785
Consensus CDS Project	CCDS24705.1, CCDS48799.1
International Mouse Knockout Project Status	Anxa6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006325	VEGA Gene Model | MGI Sequence Detail	54338	C57BL/6J
transcript	OTTMUST00000014362	VEGA | MGI Sequence Detail	2489	Not Applicable
polypeptide	OTTMUSP00000006658	VEGA | MGI Sequence Detail	673	Not Applicable

All sequences(63) RefSeq(4) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(259 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001464	Annexin
InterPro	IPR018502	Annexin repeat
InterPro	IPR018252	Annexin repeat, conserved site
InterPro	IPR002393	Annexin, type VI
Protein Ontology	PR:000004079	annexin A6

References

(Earliest) J:14450 Moss SE, et al., Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family. Eur J Biochem. 1988 Oct 15;177(1):21-7
(Latest) J:195700 Chlystun M, et al., Regulation of mitochondrial morphogenesis by annexin A6. PLoS One. 2013;8(1):e53774
All references(58)

Other accession IDs

MGD-MRK-1719, MGD-MRK-1742, MGI:2144494