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Anxa6 Gene Detail
Summary
  • Symbol
    Anxa6
  • Name
    annexin A6
  • Synonyms
    Annexin VI, Anx6, AnxVI, Cabm, Camb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88255
    NCBI Gene: 11749
Location & Maps
more
  • Sequence Map
    Chr11:54979108-55033445 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54338 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ANXA6, annexin A6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANXA6, annexin A6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANX6, CBP68
  • Links
    NCBI Gene ID: 309
    neXtProt AC: NX_P08133

  • Chr Location
    5q33.1; chr5:151100706-151157882 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    39
  • Chemically induced (other)
    1
  • Gene trapped
    31
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Anxa6
  • Incidental Mutations
Mice homozygous for a knock-out allele have normal immunological development but exhibit altered cardiomyocyte mechanics and intracellular calcium signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006325 VEGA Gene Model | MGI Sequence Detail 54338 C57BL/6J ±  kb
transcript OTTMUST00000014362 VEGA | MGI Sequence Detail 2489 Not Applicable  
polypeptide OTTMUSP00000006658 VEGA | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    602 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 288
    Genomic 1
    cDNA 287

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1719, MGD-MRK-1742, MGI:2144494
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:14450 Moss SE, et al., Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family. Eur J Biochem. 1988 Oct 15;177(1):21-7
  • Latest
    J:225710 Tuck E, et al., A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech. 2015 Nov 1;8(11):1467-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory